dc.contributor.author |
Leong, Karen SW |
|
dc.contributor.author |
Jayasinghe, Thilini N |
|
dc.contributor.author |
Wilson, Brooke C |
|
dc.contributor.author |
Derraik, José GB |
|
dc.contributor.author |
Albert, Benjamin B |
|
dc.contributor.author |
Chiavaroli, Valentina |
|
dc.contributor.author |
Svirskis, Darren M |
|
dc.contributor.author |
Beck, Kathryn L |
|
dc.contributor.author |
Conlon, Cathryn A |
|
dc.contributor.author |
Jiang, Yannan |
|
dc.contributor.author |
Schierding, William |
|
dc.contributor.author |
Vatanen, Tommi |
|
dc.contributor.author |
Holland, David J |
|
dc.contributor.author |
O'Sullivan, Justin M |
|
dc.contributor.author |
Cutfield, Wayne S |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2021-07-15T21:34:54Z |
|
dc.date.available |
2021-07-15T21:34:54Z |
|
dc.date.issued |
2020-11-18 |
|
dc.identifier.citation |
Scientific reports 10(1):20101 18 Nov 2020 |
|
dc.identifier.issn |
2045-2322 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/55573 |
|
dc.description.abstract |
Metabolic diseases are increasing among adolescents with obesity. Although the reported prevalence of metabolic syndrome is approximately 30% worldwide, its prevalence is largely unknown among New Zealand adolescents. Therefore, we assessed the health of adolescents with obesity (BMI ≥ 30 kg/m<sup>2</sup>) enrolled in a randomised clinical trial (Gut Bugs Trial), to identify the prevalence of undiagnosed comorbidities. Assessments included anthropometry, 24-h ambulatory blood pressure monitoring, and insulin sensitivity. We report on baseline data (pre-randomisation) on 87 participants (14-18 years; 59% females), with mean BMI 36.9 ± 5.3 kg/m<sup>2</sup> (BMI SDS 3.33 ± 0.79). Approximately 40% of participants had undiagnosed metabolic syndrome, which was twice as common among males. Half (53%) had pre-diabetes and 92% a reduction in insulin sensitivity. Moreover, 31% had pre-hypertension/hypertension, 69% dyslipidaemia, and 25% abnormal liver function. Participants with class III obesity had a greater risk of metabolic syndrome than those with classes I/II [relative risk 1.99 (95% CI 1.19, 3.34)]. Risks for pre-hypertension/hypertension and inflammation were also greater among those with class III obesity. We identified a high prevalence of undiagnosed comorbidities among adolescents with obesity in New Zealand. As adolescent obesity tracks into adulthood, early interventions are needed to prevent progression to overt cardiometabolic diseases. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
Springer Science and Business Media LLC |
|
dc.relation.ispartofseries |
Scientific reports |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Humans |
|
dc.subject |
Prediabetic State |
|
dc.subject |
Insulin Resistance |
|
dc.subject |
Blood Pressure Monitoring, Ambulatory |
|
dc.subject |
Body Mass Index |
|
dc.subject |
Prevalence |
|
dc.subject |
Comorbidity |
|
dc.subject |
Socioeconomic Factors |
|
dc.subject |
Adolescent |
|
dc.subject |
New Zealand |
|
dc.subject |
Female |
|
dc.subject |
Male |
|
dc.subject |
Dyslipidemias |
|
dc.subject |
Waist Circumference |
|
dc.subject |
Prehypertension |
|
dc.subject |
Pediatric Obesity |
|
dc.subject |
Metabolic Syndrome |
|
dc.subject |
Undiagnosed Diseases |
|
dc.subject |
Adolescent |
|
dc.subject |
Blood Pressure Monitoring, Ambulatory |
|
dc.subject |
Body Mass Index |
|
dc.subject |
Comorbidity |
|
dc.subject |
Dyslipidemias |
|
dc.subject |
Female |
|
dc.subject |
Humans |
|
dc.subject |
Insulin Resistance |
|
dc.subject |
Male |
|
dc.subject |
Metabolic Syndrome |
|
dc.subject |
New Zealand |
|
dc.subject |
Pediatric Obesity |
|
dc.subject |
Prediabetic State |
|
dc.subject |
Prehypertension |
|
dc.subject |
Prevalence |
|
dc.subject |
Socioeconomic Factors |
|
dc.subject |
Undiagnosed Diseases |
|
dc.subject |
Waist Circumference |
|
dc.subject |
Science & Technology |
|
dc.subject |
Multidisciplinary Sciences |
|
dc.subject |
Science & Technology - Other Topics |
|
dc.subject |
METABOLIC SYNDROME |
|
dc.subject |
INSULIN SENSITIVITY |
|
dc.subject |
US ADOLESCENTS |
|
dc.subject |
RISK-FACTORS |
|
dc.subject |
EUROPEAN-SOCIETY |
|
dc.subject |
BLOOD-PRESSURE |
|
dc.subject |
CHILDREN |
|
dc.subject |
TRENDS |
|
dc.subject |
OVERWEIGHT |
|
dc.subject |
RESISTANCE |
|
dc.title |
High prevalence of undiagnosed comorbidities among adolescents with obesity. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1038/s41598-020-76921-6 |
|
pubs.issue |
1 |
|
pubs.begin-page |
20101 |
|
pubs.volume |
10 |
|
dc.date.updated |
2021-06-08T21:59:46Z |
|
dc.rights.holder |
Copyright: The authors |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33208826 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
827979 |
|
dc.identifier.eissn |
2045-2322 |
|
dc.identifier.pii |
10.1038/s41598-020-76921-6 |
|
pubs.number |
20101 |
|
pubs.online-publication-date |
2020-11-18 |
|