Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-<i>O</i>-Acyl Derivatives of Quercetin.

Lo, Stephen; Leung, Euphemia; Fedrizzi, Bruno; Barker, David

dc.contributor.author	Lo, Stephen
dc.contributor.author	Leung, Euphemia
dc.contributor.author	Fedrizzi, Bruno
dc.contributor.author	Barker, David
dc.coverage.spatial	Switzerland
dc.date.accessioned	2021-07-19T23:23:49Z
dc.date.available	2021-07-19T23:23:49Z
dc.date.issued	2021-3-14
dc.identifier.citation	Molecules 26(6) 14 Mar 2021
dc.identifier.issn	1420-3049
dc.identifier.uri	https://hdl.handle.net/2292/55633
dc.description.abstract	Quercetin is a flavonoid that is found in many plant materials, including commonly eaten fruits and vegetables. The compound is well known for its wide range of biological activities. In this study, 5-<i>O</i>-acyl derivatives of quercetin were synthesised and assessed for their antiproliferative activity against the HCT116 colon cancer and MDA-MB-231 breast cancer cell lines; and their radical scavenging activity against the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical species. Four derivatives were found to have improved the antiproliferative activity compared to quercetin whilst retaining radical scavenging activity.
dc.format.medium	Electronic
dc.language	eng
dc.publisher	MDPI AG
dc.relation.ispartofseries	Molecules (Basel, Switzerland)
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.subject	Cell Line, Tumor
dc.subject	HCT116 Cells
dc.subject	Humans
dc.subject	Sulfonic Acids
dc.subject	Biphenyl Compounds
dc.subject	Picrates
dc.subject	Flavonoids
dc.subject	Quercetin
dc.subject	Free Radical Scavengers
dc.subject	Cell Proliferation
dc.subject	Benzothiazoles
dc.subject	antiproliferative
dc.subject	breast cancer
dc.subject	colon cancer
dc.subject	quercetin
dc.subject	radical scavenging
dc.subject	Benzothiazoles
dc.subject	Biphenyl Compounds
dc.subject	Cell Line, Tumor
dc.subject	Cell Proliferation
dc.subject	Flavonoids
dc.subject	Free Radical Scavengers
dc.subject	HCT116 Cells
dc.subject	Humans
dc.subject	Picrates
dc.subject	Quercetin
dc.subject	Sulfonic Acids
dc.subject	Science & Technology
dc.subject	Life Sciences & Biomedicine
dc.subject	Physical Sciences
dc.subject	Biochemistry & Molecular Biology
dc.subject	Chemistry, Multidisciplinary
dc.subject	Chemistry
dc.subject	quercetin
dc.subject	antiproliferative
dc.subject	colon cancer
dc.subject	breast cancer
dc.subject	radical scavenging
dc.subject	0304 Medicinal and Biomolecular Chemistry
dc.subject	0305 Organic Chemistry
dc.subject	0307 Theoretical and Computational Chemistry
dc.title	Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-<i>O</i>-Acyl Derivatives of Quercetin.
dc.type	Journal Article
dc.identifier.doi	10.3390/molecules26061608
pubs.issue	6
pubs.begin-page	1608
pubs.volume	26
dc.date.updated	2021-06-20T05:57:11Z
dc.rights.holder	Copyright: The authors	en
pubs.author-url	https://www.ncbi.nlm.nih.gov/pubmed/33799363
pubs.publication-status	Published
dc.rights.accessrights	http://purl.org/eprint/accessRights/OpenAccess	en
pubs.subtype	research-article
pubs.subtype	Journal Article
pubs.elements-id	844586
dc.identifier.eissn	1420-3049
dc.identifier.pii	molecules26061608
pubs.number	ARTN 1608
pubs.online-publication-date	2021-3-14