dc.contributor.author |
Lo, Stephen |
|
dc.contributor.author |
Leung, Euphemia |
|
dc.contributor.author |
Fedrizzi, Bruno |
|
dc.contributor.author |
Barker, David |
|
dc.coverage.spatial |
Switzerland |
|
dc.date.accessioned |
2021-07-19T23:23:49Z |
|
dc.date.available |
2021-07-19T23:23:49Z |
|
dc.date.issued |
2021-3-14 |
|
dc.identifier.citation |
Molecules 26(6) 14 Mar 2021 |
|
dc.identifier.issn |
1420-3049 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/55633 |
|
dc.description.abstract |
Quercetin is a flavonoid that is found in many plant materials, including commonly eaten fruits and vegetables. The compound is well known for its wide range of biological activities. In this study, 5-<i>O</i>-acyl derivatives of quercetin were synthesised and assessed for their antiproliferative activity against the HCT116 colon cancer and MDA-MB-231 breast cancer cell lines; and their radical scavenging activity against the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical species. Four derivatives were found to have improved the antiproliferative activity compared to quercetin whilst retaining radical scavenging activity. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
MDPI AG |
|
dc.relation.ispartofseries |
Molecules (Basel, Switzerland) |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Cell Line, Tumor |
|
dc.subject |
HCT116 Cells |
|
dc.subject |
Humans |
|
dc.subject |
Sulfonic Acids |
|
dc.subject |
Biphenyl Compounds |
|
dc.subject |
Picrates |
|
dc.subject |
Flavonoids |
|
dc.subject |
Quercetin |
|
dc.subject |
Free Radical Scavengers |
|
dc.subject |
Cell Proliferation |
|
dc.subject |
Benzothiazoles |
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dc.subject |
antiproliferative |
|
dc.subject |
breast cancer |
|
dc.subject |
colon cancer |
|
dc.subject |
quercetin |
|
dc.subject |
radical scavenging |
|
dc.subject |
Benzothiazoles |
|
dc.subject |
Biphenyl Compounds |
|
dc.subject |
Cell Line, Tumor |
|
dc.subject |
Cell Proliferation |
|
dc.subject |
Flavonoids |
|
dc.subject |
Free Radical Scavengers |
|
dc.subject |
HCT116 Cells |
|
dc.subject |
Humans |
|
dc.subject |
Picrates |
|
dc.subject |
Quercetin |
|
dc.subject |
Sulfonic Acids |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Physical Sciences |
|
dc.subject |
Biochemistry & Molecular Biology |
|
dc.subject |
Chemistry, Multidisciplinary |
|
dc.subject |
Chemistry |
|
dc.subject |
quercetin |
|
dc.subject |
antiproliferative |
|
dc.subject |
colon cancer |
|
dc.subject |
breast cancer |
|
dc.subject |
radical scavenging |
|
dc.subject |
0304 Medicinal and Biomolecular Chemistry |
|
dc.subject |
0305 Organic Chemistry |
|
dc.subject |
0307 Theoretical and Computational Chemistry |
|
dc.title |
Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-<i>O</i>-Acyl Derivatives of Quercetin. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.3390/molecules26061608 |
|
pubs.issue |
6 |
|
pubs.begin-page |
1608 |
|
pubs.volume |
26 |
|
dc.date.updated |
2021-06-20T05:57:11Z |
|
dc.rights.holder |
Copyright: The authors |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33799363 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
844586 |
|
dc.identifier.eissn |
1420-3049 |
|
dc.identifier.pii |
molecules26061608 |
|
pubs.number |
ARTN 1608 |
|
pubs.online-publication-date |
2021-3-14 |
|