dc.contributor.author |
Li, Danhui |
|
dc.contributor.author |
Martini, Nataly |
|
dc.contributor.author |
Liu, Mengyang |
|
dc.contributor.author |
Falconer, James R |
|
dc.contributor.author |
Locke, Michelle |
|
dc.contributor.author |
Wu, Zimei |
|
dc.contributor.author |
Wen, Jingyuan |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2021-07-20T23:38:46Z |
|
dc.date.available |
2021-07-20T23:38:46Z |
|
dc.date.issued |
2021-3 |
|
dc.identifier.issn |
1061-186X |
|
dc.identifier.uri |
https://hdl.handle.net/2292/55652 |
|
dc.description.abstract |
Numerous skin disorders and diseases are related to oxidative stress. The application of an antioxidant, serving as a strong defense agent against oxidation, is of great interest in dermatology yet remains challenging for delivery. This paper aimed to develop a niosome carrier system to deliver the antioxidant (+) Catechin into the skin. (+) Catechin-loaded niosomes were prepared using film hydration technique and the physicochemical properties of drug-loaded niosomes were characterised and investigated by a series of <i>in vitro</i> and <i>ex vivo</i> studies. The optimised formulation displayed an acceptable size in nanoscale (204 nm), high drug entrapment efficiency (49%) and amorphous state of drug in niosomes. It was found that (+) Catechin-loaded niosomes could effectively prolong the drug release. Drug deposition in the viable layers of human skin was significantly enhanced when niosomal carriers were applied (<i>p</i> < 0.05). Compared to the pure drug, the niosomal formulation had a greater protective effect on the human skin fibroblasts (Fbs). This is consistent with the observation of internalisation of niosomes by Fbs which was concentration-, time- and temperature-dependent, <i>via</i> an energy-dependent process of endocytosis. The research highlighted that niosomes are potential topical carriers for dermal delivery of antioxidants in skin-care and pharmaceutical products. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Informa UK Limited |
|
dc.relation.ispartofseries |
Journal of drug targeting |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Niosomes |
|
dc.subject |
antioxidant |
|
dc.subject |
catechin |
|
dc.subject |
cellular uptake |
|
dc.subject |
non-ionic surfactant |
|
dc.subject |
skin penetration and deposition |
|
dc.subject |
topical application |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Pharmacology & Pharmacy |
|
dc.subject |
Niosomes |
|
dc.subject |
non-ionic surfactant |
|
dc.subject |
catechin |
|
dc.subject |
antioxidant |
|
dc.subject |
topical application |
|
dc.subject |
skin penetration and deposition |
|
dc.subject |
cellular uptake |
|
dc.subject |
ENHANCED CELLULAR UPTAKE |
|
dc.subject |
GREEN TEA POLYPHENOLS |
|
dc.subject |
IN-VITRO |
|
dc.subject |
OXIDATIVE STRESS |
|
dc.subject |
SKIN PENETRATION |
|
dc.subject |
DRUG-DELIVERY |
|
dc.subject |
LIPOSOMES |
|
dc.subject |
NIOSOMES |
|
dc.subject |
ENDOCYTOSIS |
|
dc.subject |
INHIBITION |
|
dc.subject |
1115 Pharmacology and Pharmaceutical Sciences |
|
dc.title |
Non-ionic surfactant vesicles as a carrier system for dermal delivery of (+)-Catechin and their antioxidant effects. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1080/1061186x.2020.1835923 |
|
pubs.issue |
3 |
|
pubs.begin-page |
310 |
|
pubs.volume |
29 |
|
dc.date.updated |
2021-06-28T04:20:28Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33044095 |
|
pubs.end-page |
322 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.elements-id |
818028 |
|
dc.identifier.eissn |
1029-2330 |
|
pubs.number |
3 |
|
pubs.online-publication-date |
2020-10-27 |
|