Chronic Pancreatitis Is Characterized by Elevated Circulating Periostin Levels Related to Intra-Pancreatic Fat Deposition.

Show simple item record Ko, Juyeon Stuart, Charlotte E Modesto, Andre E Cho, Jaelim Bharmal, Sakina H Petrov, Maxim S
dc.coverage.spatial Canada 2021-07-27T22:09:32Z 2021-07-27T22:09:32Z 2020-9
dc.identifier.citation Journal of clinical medicine research 12(9):568-578 Sep 2020
dc.identifier.issn 1918-3003
dc.description.abstract <h4>Background</h4>Periostin is a matricellular protein that induces fibrillogenesis and activates cell migration. It is overexpressed in common fibrotic diseases and is also associated with abdominal adiposity/ectopic fat phenotypes. The study aimed to investigate circulating levels of periostin in health and after an attack of pancreatitis, as well as their associations with abdominal adiposity/ectopic fat phenotypes.<h4>Methods</h4>Blood samples were obtained from healthy controls, as well as definite chronic pancreatitis (CP) and acute pancreatitis (AP) individuals during follow-up visits. Fat depositions in the pancreas, liver, skeletal muscle, as well as visceral and subcutaneous fat volumes, were quantified with the use of magnetic resonance imaging. A series of multivariable analyses were conducted, accounting for possible confounders.<h4>Results</h4>A total of 121 individuals were included. Periostin levels were significantly higher in the CP group compared with the other groups in both unadjusted (F = 3.211, P = 0.044) and all adjusted models (F = 4.165, P = 0.019 in the most adjusted model). Intra-pancreatic fat deposition (but not the other fat phenotypes) was significantly associated with periostin concentration in the CP group (β = 49.63, P = 0.034) and explained most of its variance (32.0%).<h4>Conclusions</h4>Individuals with CP, but not healthy individuals or those after clinical resolution of AP, are characterized by elevated circulating levels of periostin that are positively associated with intra-pancreatic fat deposition.
dc.format.medium Print-Electronic
dc.language eng
dc.publisher Elmer Press, Inc.
dc.relation.ispartofseries Journal of clinical medicine research
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.subject Biomarkers
dc.subject Intra-pancreatic fat
dc.subject Liver fat
dc.subject Magnetic resonance imaging
dc.subject Pancreatitis
dc.subject Skeletal muscle fat
dc.subject Subcutaneous fat
dc.subject Visceral fat
dc.title Chronic Pancreatitis Is Characterized by Elevated Circulating Periostin Levels Related to Intra-Pancreatic Fat Deposition.
dc.type Journal Article
dc.identifier.doi 10.14740/jocmr4279
pubs.issue 9
pubs.begin-page 568
pubs.volume 12 2021-06-21T20:24:04Z
dc.rights.holder Copyright: The authors en
pubs.end-page 578
pubs.publication-status Published
dc.rights.accessrights en
pubs.subtype research-article
pubs.subtype Journal Article
pubs.elements-id 828724
dc.identifier.eissn 1918-3011

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