dc.contributor.author |
Ko, Juyeon |
|
dc.contributor.author |
Stuart, Charlotte E |
|
dc.contributor.author |
Modesto, Andre E |
|
dc.contributor.author |
Cho, Jaelim |
|
dc.contributor.author |
Bharmal, Sakina H |
|
dc.contributor.author |
Petrov, Maxim S |
|
dc.coverage.spatial |
Canada |
|
dc.date.accessioned |
2021-07-27T22:09:32Z |
|
dc.date.available |
2021-07-27T22:09:32Z |
|
dc.date.issued |
2020-9 |
|
dc.identifier.citation |
Journal of clinical medicine research 12(9):568-578 Sep 2020 |
|
dc.identifier.issn |
1918-3003 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/55714 |
|
dc.description.abstract |
<h4>Background</h4>Periostin is a matricellular protein that induces fibrillogenesis and activates cell migration. It is overexpressed in common fibrotic diseases and is also associated with abdominal adiposity/ectopic fat phenotypes. The study aimed to investigate circulating levels of periostin in health and after an attack of pancreatitis, as well as their associations with abdominal adiposity/ectopic fat phenotypes.<h4>Methods</h4>Blood samples were obtained from healthy controls, as well as definite chronic pancreatitis (CP) and acute pancreatitis (AP) individuals during follow-up visits. Fat depositions in the pancreas, liver, skeletal muscle, as well as visceral and subcutaneous fat volumes, were quantified with the use of magnetic resonance imaging. A series of multivariable analyses were conducted, accounting for possible confounders.<h4>Results</h4>A total of 121 individuals were included. Periostin levels were significantly higher in the CP group compared with the other groups in both unadjusted (F = 3.211, P = 0.044) and all adjusted models (F = 4.165, P = 0.019 in the most adjusted model). Intra-pancreatic fat deposition (but not the other fat phenotypes) was significantly associated with periostin concentration in the CP group (β = 49.63, P = 0.034) and explained most of its variance (32.0%).<h4>Conclusions</h4>Individuals with CP, but not healthy individuals or those after clinical resolution of AP, are characterized by elevated circulating levels of periostin that are positively associated with intra-pancreatic fat deposition. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elmer Press, Inc. |
|
dc.relation.ispartofseries |
Journal of clinical medicine research |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc/4.0/ |
|
dc.subject |
Biomarkers |
|
dc.subject |
Intra-pancreatic fat |
|
dc.subject |
Liver fat |
|
dc.subject |
Magnetic resonance imaging |
|
dc.subject |
Pancreatitis |
|
dc.subject |
Skeletal muscle fat |
|
dc.subject |
Subcutaneous fat |
|
dc.subject |
Visceral fat |
|
dc.title |
Chronic Pancreatitis Is Characterized by Elevated Circulating Periostin Levels Related to Intra-Pancreatic Fat Deposition. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.14740/jocmr4279 |
|
pubs.issue |
9 |
|
pubs.begin-page |
568 |
|
pubs.volume |
12 |
|
dc.date.updated |
2021-06-21T20:24:04Z |
|
dc.rights.holder |
Copyright: The authors |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/32849945 |
|
pubs.end-page |
578 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
828724 |
|
dc.identifier.eissn |
1918-3011 |
|