Cooling and immunomodulation for treating hypoxic-ischemic brain injury.

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dc.contributor.author Cho, Kenta Ht
dc.contributor.author Davidson, Joanne O
dc.contributor.author Dean, Justin M
dc.contributor.author Bennet, Laura
dc.contributor.author Gunn, Alistair J
dc.coverage.spatial Australia
dc.date.accessioned 2021-08-05T23:06:36Z
dc.date.available 2021-08-05T23:06:36Z
dc.date.issued 2020-7-9
dc.identifier.issn 1328-8067
dc.identifier.uri https://hdl.handle.net/2292/55868
dc.description.abstract Therapeutic hypothermia is now well established to partially reduce disability in term and near-term infants with moderate-severe hypoxic-ischemic encephalopathy. Preclinical and clinical studies have confirmed that current protocols for therapeutic hypothermia are near optimal. The challenge is now to identify complementary therapies that can further improve outcomes, in combination with therapeutic hypothermia. Overall, anti-excitatory and anti-apoptotic agents have shown variable or even no benefit in combination with hypothermia, suggesting overlapping mechanisms of neuroprotection. Inflammation appears to play a critical role in the pathogenesis of injury in the neonatal brain, and thus, there is potential for drugs with immunomodulatory properties that target inflammation to be used as a therapy in neonates. In this review, we examine the evidence for neuroprotection with immunomodulation after hypoxia-ischemia. For example, stem cell therapy can reduce inflammation, increase cell survival, and promote cell maturation and repair. There are also encouraging preclinical data from small animals suggesting that stem cell therapy can augment hypothermic neuroprotection. However, there is conflicting evidence, and rigorous testing in translational animal models is now needed.
dc.format.medium Print-Electronic
dc.language eng
dc.publisher Wiley
dc.relation.ispartofseries Pediatrics international : official journal of the Japan Pediatric Society
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.subject Stem Cells
dc.subject Animals
dc.subject Humans
dc.subject Brain Injuries
dc.subject Hypoxia-Ischemia, Brain
dc.subject Inflammation
dc.subject Anti-Inflammatory Agents
dc.subject Immunologic Factors
dc.subject Combined Modality Therapy
dc.subject Hypothermia, Induced
dc.subject Infant, Newborn
dc.subject Cold Temperature
dc.subject Immunomodulation
dc.subject Neuroprotection
dc.subject hypoxia-ischemia
dc.subject inflammation
dc.subject neuroprotection
dc.subject therapeutic hypothermia
dc.subject toll-like receptors
dc.subject Animals
dc.subject Anti-Inflammatory Agents
dc.subject Brain Injuries
dc.subject Cold Temperature
dc.subject Combined Modality Therapy
dc.subject Humans
dc.subject Hypothermia, Induced
dc.subject Hypoxia-Ischemia, Brain
dc.subject Immunologic Factors
dc.subject Immunomodulation
dc.subject Infant, Newborn
dc.subject Inflammation
dc.subject Neuroprotection
dc.subject Stem Cells
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Pediatrics
dc.subject hypoxia-ischemia
dc.subject inflammation
dc.subject neuroprotection
dc.subject therapeutic hypothermia
dc.subject toll-like receptors
dc.subject STEM-CELL TREATMENT
dc.subject NEONATAL-RAT
dc.subject OXIDATIVE-METABOLISM
dc.subject CEREBROSPINAL-FLUID
dc.subject CEREBRAL-ISCHEMIA
dc.subject SIGNALING PATHWAY
dc.subject ENERGY FAILURE
dc.subject MATTER INJURY
dc.subject TNF-ALPHA
dc.subject HYPOTHERMIA
dc.subject 1109 Neurosciences
dc.subject Biomedical
dc.subject Basic Science
dc.subject Neurosciences
dc.subject Infant Mortality
dc.subject Regenerative Medicine
dc.subject Perinatal Period - Conditions Originating in Perinatal Period
dc.subject Brain Disorders
dc.subject Stroke
dc.subject Injury (total) Accidents/Adverse Effects
dc.subject Pediatric
dc.subject Neurological
dc.subject 5.1 Pharmaceuticals
dc.subject 1101 Medical Biochemistry and Metabolomics
dc.subject 1103 Clinical Sciences
dc.subject 1114 Paediatrics and Reproductive Medicine
dc.title Cooling and immunomodulation for treating hypoxic-ischemic brain injury.
dc.type Journal Article
dc.identifier.doi 10.1111/ped.14215
pubs.issue 7
pubs.begin-page 770
pubs.volume 62
dc.date.updated 2021-07-21T03:54:00Z
dc.rights.holder Copyright: The author en
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/32119180
pubs.end-page 778
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/RetrictedAccess en
pubs.subtype Review
pubs.subtype Journal Article
pubs.elements-id 805778
dc.identifier.eissn 1442-200X
pubs.online-publication-date 2020-7-9


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