dc.contributor.author |
de Rojas, Itziar |
|
dc.contributor.author |
Moreno-Grau, Sonia |
|
dc.contributor.author |
Tesi, Niccolo |
|
dc.contributor.author |
Grenier-Boley, Benjamin |
|
dc.contributor.author |
Andrade, Victor |
|
dc.contributor.author |
Jansen, Iris E |
|
dc.contributor.author |
Pedersen, Nancy L |
|
dc.contributor.author |
Stringa, Najada |
|
dc.contributor.author |
Zettergren, Anna |
|
dc.contributor.author |
Hernández, Isabel |
|
dc.contributor.author |
Montrreal, Laura |
|
dc.contributor.author |
Antúnez, Carmen |
|
dc.contributor.author |
Antonell, Anna |
|
dc.contributor.author |
Tankard, Rick M |
|
dc.contributor.author |
Bis, Joshua C |
|
dc.contributor.author |
Sims, Rebecca |
|
dc.contributor.author |
Bellenguez, Céline |
|
dc.contributor.author |
Quintela, Inés |
|
dc.contributor.author |
González-Perez, Antonio |
|
dc.contributor.author |
Calero, Miguel |
|
dc.contributor.author |
Franco-Macías, Emilio |
|
dc.contributor.author |
Macías, Juan |
|
dc.contributor.author |
Blesa, Rafael |
|
dc.contributor.author |
Cervera-Carles, Laura |
|
dc.contributor.author |
Menéndez-González, Manuel |
|
dc.contributor.author |
Frank-García, Ana |
|
dc.contributor.author |
Royo, Jose Luís |
|
dc.contributor.author |
Moreno, Fermin |
|
dc.contributor.author |
Huerto Vilas, Raquel |
|
dc.contributor.author |
Baquero, Miquel |
|
dc.contributor.author |
Diez-Fairen, Mónica |
|
dc.contributor.author |
Lage, Carmen |
|
dc.contributor.author |
García-Madrona, Sebastián |
|
dc.contributor.author |
García-González, Pablo |
|
dc.contributor.author |
Alarcón-Martín, Emilio |
|
dc.contributor.author |
Valero, Sergi |
|
dc.contributor.author |
Sotolongo-Grau, Oscar |
|
dc.contributor.author |
Ullgren, Abbe |
|
dc.contributor.author |
Naj, Adam C |
|
dc.contributor.author |
Lemstra, Afina W |
|
dc.contributor.author |
Benaque, Alba |
|
dc.contributor.author |
Pérez-Cordón, Alba |
|
dc.contributor.author |
Benussi, Alberto |
|
dc.contributor.author |
Rábano, Alberto |
|
dc.contributor.author |
Padovani, Alessandro |
|
dc.contributor.author |
Squassina, Alessio |
|
dc.contributor.author |
de Mendonça, Alexandre |
|
dc.contributor.author |
Arias Pastor, Alfonso |
|
dc.contributor.author |
Kok, Almar AL |
|
dc.contributor.author |
Meggy, Alun |
|
dc.contributor.author |
Pastor, Ana Belén |
|
dc.contributor.author |
Espinosa, Ana |
|
dc.contributor.author |
Corma-Gómez, Anaïs |
|
dc.contributor.author |
Martín Montes, Angel |
|
dc.contributor.author |
Sanabria, Ángela |
|
dc.contributor.author |
DeStefano, Anita L |
|
dc.contributor.author |
Schneider, Anja |
|
dc.contributor.author |
Haapasalo, Annakaisa |
|
dc.contributor.author |
Kinhult Ståhlbom, Anne |
|
dc.contributor.author |
Tybjærg-Hansen, Anne |
|
dc.contributor.author |
Hartmann, Annette M |
|
dc.contributor.author |
Spottke, Annika |
|
dc.contributor.author |
Corbatón-Anchuelo, Arturo |
|
dc.contributor.author |
Rongve, Arvid |
|
dc.contributor.author |
Borroni, Barbara |
|
dc.contributor.author |
Arosio, Beatrice |
|
dc.contributor.author |
Nacmias, Benedetta |
|
dc.contributor.author |
Nordestgaard, Børge G |
|
dc.contributor.author |
Kunkle, Brian W |
|
dc.contributor.author |
Charbonnier, Camille |
|
dc.contributor.author |
Abdelnour, Carla |
|
dc.contributor.author |
Masullo, Carlo |
|
dc.contributor.author |
Martínez Rodríguez, Carmen |
|
dc.contributor.author |
Muñoz-Fernandez, Carmen |
|
dc.contributor.author |
Dufouil, Carole |
|
dc.contributor.author |
Graff, Caroline |
|
dc.contributor.author |
Ferreira, Catarina B |
|
dc.contributor.author |
Chillotti, Caterina |
|
dc.contributor.author |
Reynolds, Chandra A |
|
dc.contributor.author |
Fenoglio, Chiara |
|
dc.contributor.author |
Van Broeckhoven, Christine |
|
dc.contributor.author |
Clark, Christopher |
|
dc.contributor.author |
Pisanu, Claudia |
|
dc.contributor.author |
Satizabal, Claudia L |
|
dc.contributor.author |
Holmes, Clive |
|
dc.contributor.author |
Buiza-Rueda, Dolores |
|
dc.contributor.author |
Aarsland, Dag |
|
dc.contributor.author |
Rujescu, Dan |
|
dc.contributor.author |
Alcolea, Daniel |
|
dc.contributor.author |
Galimberti, Daniela |
|
dc.contributor.author |
Wallon, David |
|
dc.contributor.author |
Seripa, Davide |
|
dc.contributor.author |
Grünblatt, Edna |
|
dc.contributor.author |
Dardiotis, Efthimios |
|
dc.contributor.author |
Düzel, Emrah |
|
dc.contributor.author |
Scarpini, Elio |
|
dc.contributor.author |
Conti, Elisa |
|
dc.contributor.author |
Rubino, Elisa |
|
dc.contributor.author |
Gelpi, Ellen |
|
dc.contributor.author |
Rodriguez-Rodriguez, Eloy |
|
dc.contributor.author |
Duron, Emmanuelle |
|
dc.contributor.author |
Boerwinkle, Eric |
|
dc.contributor.author |
Ferri, Evelyn |
|
dc.contributor.author |
Tagliavini, Fabrizio |
|
dc.contributor.author |
Küçükali, Fahri |
|
dc.contributor.author |
Pasquier, Florence |
|
dc.contributor.author |
Sanchez-Garcia, Florentino |
|
dc.contributor.author |
Mangialasche, Francesca |
|
dc.contributor.author |
Jessen, Frank |
|
dc.contributor.author |
Nicolas, Gaël |
|
dc.contributor.author |
Selbæk, Geir |
|
dc.contributor.author |
Ortega, Gemma |
|
dc.contributor.author |
Chêne, Geneviève |
|
dc.contributor.author |
Hadjigeorgiou, Georgios |
|
dc.contributor.author |
Rossi, Giacomina |
|
dc.contributor.author |
Spalletta, Gianfranco |
|
dc.contributor.author |
Giaccone, Giorgio |
|
dc.contributor.author |
Grande, Giulia |
|
dc.contributor.author |
Binetti, Giuliano |
|
dc.contributor.author |
Papenberg, Goran |
|
dc.contributor.author |
Hampel, Harald |
|
dc.contributor.author |
Bailly, Henri |
|
dc.contributor.author |
Zetterberg, Henrik |
|
dc.contributor.author |
Soininen, Hilkka |
|
dc.contributor.author |
Karlsson, Ida K |
|
dc.contributor.author |
Alvarez, Ignacio |
|
dc.contributor.author |
Appollonio, Ildebrando |
|
dc.contributor.author |
Giegling, Ina |
|
dc.contributor.author |
Skoog, Ingmar |
|
dc.contributor.author |
Saltvedt, Ingvild |
|
dc.contributor.author |
Rainero, Innocenzo |
|
dc.contributor.author |
Rosas Allende, Irene |
|
dc.contributor.author |
Hort, Jakub |
|
dc.contributor.author |
Diehl-Schmid, Janine |
|
dc.contributor.author |
Van Dongen, Jasper |
|
dc.contributor.author |
Vidal, Jean-Sebastien |
|
dc.contributor.author |
Lehtisalo, Jenni |
|
dc.contributor.author |
Wiltfang, Jens |
|
dc.contributor.author |
Thomassen, Jesper Qvist |
|
dc.contributor.author |
Kornhuber, Johannes |
|
dc.contributor.author |
Haines, Jonathan L |
|
dc.contributor.author |
Vogelgsang, Jonathan |
|
dc.contributor.author |
Pineda, Juan A |
|
dc.contributor.author |
Fortea, Juan |
|
dc.contributor.author |
Popp, Julius |
|
dc.contributor.author |
Deckert, Jürgen |
|
dc.contributor.author |
Buerger, Katharina |
|
dc.contributor.author |
Morgan, Kevin |
|
dc.contributor.author |
Fließbach, Klaus |
|
dc.contributor.author |
Sleegers, Kristel |
|
dc.contributor.author |
Molina-Porcel, Laura |
|
dc.contributor.author |
Kilander, Lena |
|
dc.contributor.author |
Weinhold, Leonie |
|
dc.contributor.author |
Farrer, Lindsay A |
|
dc.contributor.author |
Wang, Li-San |
|
dc.contributor.author |
Kleineidam, Luca |
|
dc.contributor.author |
Farotti, Lucia |
|
dc.contributor.author |
Parnetti, Lucilla |
|
dc.contributor.author |
Tremolizzo, Lucio |
|
dc.contributor.author |
Hausner, Lucrezia |
|
dc.contributor.author |
Benussi, Luisa |
|
dc.contributor.author |
Froelich, Lutz |
|
dc.contributor.author |
Ikram, M Arfan |
|
dc.contributor.author |
Deniz-Naranjo, M Candida |
|
dc.contributor.author |
Tsolaki, Magda |
|
dc.contributor.author |
Rosende-Roca, Maitée |
|
dc.contributor.author |
Löwenmark, Malin |
|
dc.contributor.author |
Hulsman, Marc |
|
dc.contributor.author |
Spallazzi, Marco |
|
dc.contributor.author |
Pericak-Vance, Margaret A |
|
dc.contributor.author |
Esiri, Margaret |
|
dc.contributor.author |
Bernal Sánchez-Arjona, María |
|
dc.contributor.author |
Dalmasso, Maria Carolina |
|
dc.contributor.author |
Martínez-Larrad, María Teresa |
|
dc.contributor.author |
Arcaro, Marina |
|
dc.contributor.author |
Nöthen, Markus M |
|
dc.contributor.author |
Fernández-Fuertes, Marta |
|
dc.contributor.author |
Dichgans, Martin |
|
dc.contributor.author |
Ingelsson, Martin |
|
dc.contributor.author |
Herrmann, Martin J |
|
dc.contributor.author |
Scherer, Martin |
|
dc.contributor.author |
Vyhnalek, Martin |
|
dc.contributor.author |
Kosmidis, Mary H |
|
dc.contributor.author |
Yannakoulia, Mary |
|
dc.contributor.author |
Schmid, Matthias |
|
dc.contributor.author |
Ewers, Michael |
|
dc.contributor.author |
Heneka, Michael T |
|
dc.contributor.author |
Wagner, Michael |
|
dc.contributor.author |
Scamosci, Michela |
|
dc.contributor.author |
Kivipelto, Miia |
|
dc.contributor.author |
Hiltunen, Mikko |
|
dc.contributor.author |
Zulaica, Miren |
|
dc.contributor.author |
Alegret, Montserrat |
|
dc.contributor.author |
Fornage, Myriam |
|
dc.contributor.author |
Roberto, Natalia |
|
dc.contributor.author |
van Schoor, Natasja M |
|
dc.contributor.author |
Seidu, Nazib M |
|
dc.contributor.author |
Banaj, Nerisa |
|
dc.contributor.author |
Armstrong, Nicola J |
|
dc.contributor.author |
Scarmeas, Nikolaos |
|
dc.contributor.author |
Scherbaum, Norbert |
|
dc.contributor.author |
Goldhardt, Oliver |
|
dc.contributor.author |
Hanon, Oliver |
|
dc.contributor.author |
Peters, Oliver |
|
dc.contributor.author |
Skrobot, Olivia Anna |
|
dc.contributor.author |
Quenez, Olivier |
|
dc.contributor.author |
Lerch, Ondrej |
|
dc.contributor.author |
Bossù, Paola |
|
dc.contributor.author |
Caffarra, Paolo |
|
dc.contributor.author |
Dionigi Rossi, Paolo |
|
dc.contributor.author |
Sakka, Paraskevi |
|
dc.contributor.author |
Hoffmann, Per |
|
dc.contributor.author |
Holmans, Peter A |
|
dc.contributor.author |
Fischer, Peter |
|
dc.contributor.author |
Riederer, Peter |
|
dc.contributor.author |
Yang, Qiong |
|
dc.contributor.author |
Marshall, Rachel |
|
dc.contributor.author |
Kalaria, Rajesh N |
|
dc.contributor.author |
Mayeux, Richard |
|
dc.contributor.author |
Vandenberghe, Rik |
|
dc.contributor.author |
Cecchetti, Roberta |
|
dc.contributor.author |
Ghidoni, Roberta |
|
dc.contributor.author |
Frikke-Schmidt, Ruth |
|
dc.contributor.author |
Sorbi, Sandro |
|
dc.contributor.author |
Hägg, Sara |
|
dc.contributor.author |
Engelborghs, Sebastiaan |
|
dc.contributor.author |
Helisalmi, Seppo |
|
dc.contributor.author |
Botne Sando, Sigrid |
|
dc.contributor.author |
Kern, Silke |
|
dc.contributor.author |
Archetti, Silvana |
|
dc.contributor.author |
Boschi, Silvia |
|
dc.contributor.author |
Fostinelli, Silvia |
|
dc.contributor.author |
Gil, Silvia |
|
dc.contributor.author |
Mendoza, Silvia |
|
dc.contributor.author |
Mead, Simon |
|
dc.contributor.author |
Ciccone, Simona |
|
dc.contributor.author |
Djurovic, Srdjan |
|
dc.contributor.author |
Heilmann-Heimbach, Stefanie |
|
dc.contributor.author |
Riedel-Heller, Steffi |
|
dc.contributor.author |
Kuulasmaa, Teemu |
|
dc.contributor.author |
Del Ser, Teodoro |
|
dc.contributor.author |
Lebouvier, Thibaud |
|
dc.contributor.author |
Polak, Thomas |
|
dc.contributor.author |
Ngandu, Tiia |
|
dc.contributor.author |
Grimmer, Timo |
|
dc.contributor.author |
Bessi, Valentina |
|
dc.contributor.author |
Escott-Price, Valentina |
|
dc.contributor.author |
Giedraitis, Vilmantas |
|
dc.contributor.author |
Deramecourt, Vincent |
|
dc.contributor.author |
Maier, Wolfgang |
|
dc.contributor.author |
Jian, Xueqiu |
|
dc.contributor.author |
Pijnenburg, Yolande AL |
|
dc.contributor.author |
EADB contributors |
|
dc.contributor.author |
GR@ACE study group |
|
dc.contributor.author |
DEGESCO consortium |
|
dc.contributor.author |
IGAP (ADGC, CHARGE, EADI, GERAD) |
|
dc.contributor.author |
PGC-ALZ consortia |
|
dc.contributor.author |
Kehoe, Patrick Gavin |
|
dc.contributor.author |
Garcia-Ribas, Guillermo |
|
dc.contributor.author |
Sánchez-Juan, Pascual |
|
dc.contributor.author |
Pastor, Pau |
|
dc.contributor.author |
Pérez-Tur, Jordi |
|
dc.contributor.author |
Piñol-Ripoll, Gerard |
|
dc.contributor.author |
Lopez de Munain, Adolfo |
|
dc.contributor.author |
García-Alberca, Jose María |
|
dc.contributor.author |
Bullido, María J |
|
dc.contributor.author |
Álvarez, Victoria |
|
dc.contributor.author |
Lleó, Alberto |
|
dc.contributor.author |
Real, Luis M |
|
dc.contributor.author |
Mir, Pablo |
|
dc.contributor.author |
Medina, Miguel |
|
dc.contributor.author |
Scheltens, Philip |
|
dc.contributor.author |
Holstege, Henne |
|
dc.contributor.author |
Marquié, Marta |
|
dc.contributor.author |
Sáez, María Eugenia |
|
dc.contributor.author |
Carracedo, Ángel |
|
dc.contributor.author |
Amouyel, Philippe |
|
dc.contributor.author |
Schellenberg, Gerard D |
|
dc.contributor.author |
Williams, Julie |
|
dc.contributor.author |
Seshadri, Sudha |
|
dc.contributor.author |
van Duijn, Cornelia M |
|
dc.contributor.author |
Mather, Karen A |
|
dc.contributor.author |
Sánchez-Valle, Raquel |
|
dc.contributor.author |
Serrano-Ríos, Manuel |
|
dc.contributor.author |
Orellana, Adelina |
|
dc.contributor.author |
Tárraga, Lluís |
|
dc.contributor.author |
Blennow, Kaj |
|
dc.contributor.author |
Huisman, Martijn |
|
dc.contributor.author |
Andreassen, Ole A |
|
dc.contributor.author |
Posthuma, Danielle |
|
dc.contributor.author |
Clarimón, Jordi |
|
dc.contributor.author |
Boada, Mercè |
|
dc.contributor.author |
van der Flier, Wiesje M |
|
dc.contributor.author |
Ramirez, Alfredo |
|
dc.contributor.author |
Lambert, Jean-Charles |
|
dc.contributor.author |
van der Lee, Sven J |
|
dc.contributor.author |
Ruiz, Agustín |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2021-08-11T22:01:31Z |
|
dc.date.available |
2021-08-11T22:01:31Z |
|
dc.date.issued |
2021-6-7 |
|
dc.identifier.citation |
Nature communications 12(1):3417 07 Jun 2021 |
|
dc.identifier.issn |
2041-1723 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/55962 |
|
dc.description.abstract |
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
Springer Science and Business Media LLC |
|
dc.relation.ispartofseries |
Nature communications |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
EADB contributors |
|
dc.subject |
GR@ACE study group |
|
dc.subject |
DEGESCO consortium |
|
dc.subject |
IGAP (ADGC, CHARGE, EADI, GERAD) |
|
dc.subject |
PGC-ALZ consortia |
|
dc.subject |
Humans |
|
dc.subject |
Alzheimer Disease |
|
dc.subject |
Genetic Predisposition to Disease |
|
dc.subject |
Amyloid beta-Protein Precursor |
|
dc.subject |
Apolipoproteins E |
|
dc.subject |
Risk Assessment |
|
dc.subject |
Risk Factors |
|
dc.subject |
Case-Control Studies |
|
dc.subject |
Cohort Studies |
|
dc.subject |
Follow-Up Studies |
|
dc.subject |
Age of Onset |
|
dc.subject |
Heterozygote |
|
dc.subject |
Multifactorial Inheritance |
|
dc.subject |
Polymorphism, Single Nucleotide |
|
dc.subject |
Aged |
|
dc.subject |
Aged, 80 and over |
|
dc.subject |
Middle Aged |
|
dc.subject |
Female |
|
dc.subject |
Male |
|
dc.subject |
Genome-Wide Association Study |
|
dc.subject |
Datasets as Topic |
|
dc.subject |
Age of Onset |
|
dc.subject |
Aged |
|
dc.subject |
Aged, 80 and over |
|
dc.subject |
Alzheimer Disease |
|
dc.subject |
Amyloid beta-Protein Precursor |
|
dc.subject |
Apolipoproteins E |
|
dc.subject |
Case-Control Studies |
|
dc.subject |
Cohort Studies |
|
dc.subject |
Datasets as Topic |
|
dc.subject |
Female |
|
dc.subject |
Follow-Up Studies |
|
dc.subject |
Genetic Predisposition to Disease |
|
dc.subject |
Genome-Wide Association Study |
|
dc.subject |
Heterozygote |
|
dc.subject |
Humans |
|
dc.subject |
Male |
|
dc.subject |
Middle Aged |
|
dc.subject |
Multifactorial Inheritance |
|
dc.subject |
Polymorphism, Single Nucleotide |
|
dc.subject |
Risk Assessment |
|
dc.subject |
Risk Factors |
|
dc.title |
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1038/s41467-021-22491-8 |
|
pubs.issue |
1 |
|
pubs.begin-page |
3417 |
|
pubs.volume |
12 |
|
dc.date.updated |
2021-07-07T19:59:24Z |
|
dc.rights.holder |
Copyright: The authors |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/34099642 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
research-article |
|
pubs.subtype |
Validation Study |
|
pubs.subtype |
Journal Article |
|
pubs.subtype |
Research Support, N.I.H., Extramural |
|
pubs.elements-id |
858599 |
|
dc.identifier.eissn |
2041-1723 |
|
dc.identifier.pii |
10.1038/s41467-021-22491-8 |
|
pubs.number |
3417 |
|
pubs.online-publication-date |
2021-6-7 |
|