dc.contributor.author |
Lim, Julie C |
|
dc.contributor.author |
Caballero Arredondo, Mariana |
|
dc.contributor.author |
Braakhuis, Andrea J |
|
dc.contributor.author |
Donaldson, Paul J |
|
dc.coverage.spatial |
Switzerland |
|
dc.date.accessioned |
2021-08-15T22:34:03Z |
|
dc.date.available |
2021-08-15T22:34:03Z |
|
dc.date.issued |
2020-10-14 |
|
dc.identifier.citation |
Nutrients 12(10) 14 Oct 2020 |
|
dc.identifier.issn |
2072-6643 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/56018 |
|
dc.description.abstract |
Cataracts or clouding of the lens is the leading cause of blindness in the world. Age and diabetes are major risk factors, and with an increasing aging and diabetic population, the burden of cataracts will grow. Cataract surgery is an effective way to restore vision; however, alternatives to cataract surgery are required to reduce the looming cataract epidemic. Since it is well established that oxidative damage plays a major role in the etiology of cataracts, antioxidants have been promoted as therapies to delay and/or prevent cataracts. However, many antioxidant interventions including vitamin C have produced mixed results as anti-cataract therapies. Progress has been made towards our understanding of lens physiology and the mechanisms involved in the delivery and uptake of antioxidants to the lens which may guide future studies aimed at addressing some of the inconsistencies seen in previous animal and human studies. Of interest is the potential for vitamin C based supplements in delaying the onset of cataracts post vitrectomy which occurs in up to 80% of patients within two years. These targeted approaches are required to reduce the burden of cataract on hospitals and improve the quality of life of our aging and diabetic population. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
MDPI AG |
|
dc.relation.ispartofseries |
Nutrients |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Vitreous Body |
|
dc.subject |
Animals |
|
dc.subject |
Humans |
|
dc.subject |
Cataract |
|
dc.subject |
Diabetes Complications |
|
dc.subject |
Ascorbic Acid |
|
dc.subject |
Antioxidants |
|
dc.subject |
Vitrectomy |
|
dc.subject |
Risk Factors |
|
dc.subject |
Oxidative Stress |
|
dc.subject |
Aging |
|
dc.subject |
Dietary Supplements |
|
dc.subject |
Nutritional Physiological Phenomena |
|
dc.subject |
cataract |
|
dc.subject |
lens |
|
dc.subject |
oxidative stress |
|
dc.subject |
vitamin C |
|
dc.subject |
vitrectomy |
|
dc.subject |
vitreous humor |
|
dc.subject |
Aging |
|
dc.subject |
Animals |
|
dc.subject |
Antioxidants |
|
dc.subject |
Ascorbic Acid |
|
dc.subject |
Cataract |
|
dc.subject |
Diabetes Complications |
|
dc.subject |
Dietary Supplements |
|
dc.subject |
Humans |
|
dc.subject |
Nutritional Physiological Phenomena |
|
dc.subject |
Oxidative Stress |
|
dc.subject |
Risk Factors |
|
dc.subject |
Vitrectomy |
|
dc.subject |
Vitreous Body |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Nutrition & Dietetics |
|
dc.subject |
vitamin C |
|
dc.subject |
lens |
|
dc.subject |
cataract |
|
dc.subject |
oxidative stress |
|
dc.subject |
vitreous humor |
|
dc.subject |
vitrectomy |
|
dc.subject |
AGE-RELATED CATARACT |
|
dc.subject |
NUCLEAR SCLEROTIC CATARACT |
|
dc.subject |
B-INDUCED CATARACT |
|
dc.subject |
ASCORBIC-ACID |
|
dc.subject |
SUPPLEMENT USE |
|
dc.subject |
AQUEOUS-HUMOR |
|
dc.subject |
MAILLARD REACTION |
|
dc.subject |
OXIDATIVE STRESS |
|
dc.subject |
RISK-FACTORS |
|
dc.subject |
DIETARY-SUPPLEMENT |
|
dc.subject |
0908 Food Sciences |
|
dc.subject |
1111 Nutrition and Dietetics |
|
dc.title |
Vitamin C and the Lens: New Insights into Delaying the Onset of Cataract. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.3390/nu12103142 |
|
pubs.issue |
10 |
|
pubs.begin-page |
3142 |
|
pubs.volume |
12 |
|
dc.date.updated |
2021-07-22T08:41:25Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33066702 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
review-article |
|
pubs.subtype |
Review |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
820584 |
|
dc.identifier.eissn |
2072-6643 |
|
dc.identifier.pii |
nu12103142 |
|
pubs.number |
ARTN 3142 |
|
pubs.online-publication-date |
2020-10-14 |
|