dc.contributor.author |
Zhou, Kelly Q |
|
dc.contributor.author |
McDouall, Alice |
|
dc.contributor.author |
Drury, Paul P |
|
dc.contributor.author |
Lear, Christopher A |
|
dc.contributor.author |
Cho, Kenta HT |
|
dc.contributor.author |
Bennet, Laura |
|
dc.contributor.author |
Gunn, Alistair J |
|
dc.contributor.author |
Davidson, Joanne O |
|
dc.date.accessioned |
2021-08-15T22:49:12Z |
|
dc.date.available |
2021-08-15T22:49:12Z |
|
dc.date.issued |
2021-7-1 |
|
dc.identifier.citation |
International journal of molecular sciences 22(13) Jul 2021 |
|
dc.identifier.issn |
1661-6596 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/56023 |
|
dc.description.abstract |
<jats:p>Seizures are common in newborn infants with hypoxic-ischemic encephalopathy and are highly associated with adverse neurodevelopmental outcomes. The impact of seizure activity on the developing brain and the most effective way to manage these seizures remain surprisingly poorly understood, particularly in the era of therapeutic hypothermia. Critically, the extent to which seizures exacerbate brain injury or merely reflect the underlying evolution of injury is unclear. Current anticonvulsants, such as phenobarbital and phenytoin have poor efficacy and preclinical studies suggest that most anticonvulsants are associated with adverse effects on the developing brain. Levetiracetam seems to have less potential neurotoxic effects than other anticonvulsants but may not be more effective. Given that therapeutic hypothermia itself has significant anticonvulsant effects, randomized controlled trials of anticonvulsants combined with therapeutic hypothermia, are required to properly determine the safety and efficacy of these drugs. Small clinical studies suggest that prophylactic phenobarbital administration may improve neurodevelopmental outcomes compared to delayed administration; however, larger high-quality studies are required to confirm this. In conclusion, there is a distinct lack of high-quality evidence for whether and to what extent neonatal seizures exacerbate brain damage after hypoxia-ischemia and how best to manage them in the era of therapeutic hypothermia.</jats:p> |
|
dc.language |
en |
|
dc.publisher |
MDPI AG |
|
dc.relation.ispartofseries |
International Journal of Molecular Sciences |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Physical Sciences |
|
dc.subject |
Biochemistry & Molecular Biology |
|
dc.subject |
Chemistry, Multidisciplinary |
|
dc.subject |
Chemistry |
|
dc.subject |
hypoxic-ischemic encephalopathy |
|
dc.subject |
asphyxia |
|
dc.subject |
seizures |
|
dc.subject |
antiepileptic drugs |
|
dc.subject |
anticonvulsants |
|
dc.subject |
therapeutic hypothermia |
|
dc.subject |
phenobarbital |
|
dc.subject |
levetiracetam |
|
dc.subject |
NEONATAL SEIZURES |
|
dc.subject |
ANTIEPILEPTIC DRUGS |
|
dc.subject |
STATUS-EPILEPTICUS |
|
dc.subject |
THERAPEUTIC HYPOTHERMIA |
|
dc.subject |
BRAIN |
|
dc.subject |
LEVETIRACETAM |
|
dc.subject |
MECHANISMS |
|
dc.subject |
NEWBORNS |
|
dc.subject |
BURDEN |
|
dc.subject |
INJURY |
|
dc.subject |
0399 Other Chemical Sciences |
|
dc.subject |
0604 Genetics |
|
dc.subject |
0699 Other Biological Sciences |
|
dc.title |
Treating Seizures after Hypoxic-Ischemic Encephalopathy—Current Controversies and Future Directions |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.3390/ijms22137121 |
|
pubs.issue |
13 |
|
pubs.begin-page |
7121 |
|
pubs.volume |
22 |
|
dc.date.updated |
2021-07-21T03:59:12Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000671364100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d |
|
pubs.publication-status |
Published online |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Review |
|
pubs.subtype |
Journal |
|
pubs.elements-id |
858537 |
|
dc.identifier.eissn |
1422-0067 |
|
pubs.number |
ARTN 7121 |
|
pubs.online-publication-date |
2021-7-1 |
|