Decoding the multimorbidities among psychiatric disorders and cognitive functioning

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dc.contributor.author Golovina, E
dc.contributor.author Vickers, MH
dc.contributor.author Erb, CD
dc.contributor.author O’Sullivan, JM
dc.date.accessioned 2021-08-17T00:46:20Z
dc.date.available 2021-08-17T00:46:20Z
dc.date.issued 2019-11-11
dc.identifier.citation BioRxiv. 11 Nov 2019. 42 pages
dc.identifier.uri https://hdl.handle.net/2292/56043
dc.description.abstract Abstract The regulatory contribution that single-nucleotide polymorphisms (SNPs) associated with psychiatric and cognitive phenotypes make to multimorbidity is unknown. Here, we integrate 3D genome organization and expression quantitative trait (eQTL) analyses to identify the genes and biological pathways that are functionally impacted by 2,893 GWAS SNPs associated with cognitive functioning and five psychiatric disorders (i.e. attention deficit hyperactivity disorder (ADHD), anxiety, bipolar disorder (BD), unipolar depression (UD) and schizophrenia (SCZ)). The analysis revealed 33 genes and 62 pathways that were commonly affected by the gene regulatory interactions associated with all six phenotypes despite there being no common SNPs and eQTLs. 38 ADHD-, 78 anxiety-, 81 BD-, 169 UD-, 225 SCZ- and 185 cognition-associated genes represent known drug targets. Four genes were affected by eQTLs from all six phenotypes. Collectively, our results represent the foundation for a shift from a gene-targeted towards a pathway-based approach to the treatment of multimorbid conditions.
dc.publisher Cold Spring Harbor Laboratory
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Decoding the multimorbidities among psychiatric disorders and cognitive functioning
dc.type Journal Article
dc.identifier.doi 10.1101/837914
dc.date.updated 2021-07-08T01:29:25Z
dc.rights.holder Copyright: The author en
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Preprint
pubs.elements-id 786859


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