dc.contributor.author |
Wu, Zhenqiang |
|
dc.contributor.author |
Camargo, Carlos A |
|
dc.contributor.author |
Malihi, Zarintaj |
|
dc.contributor.author |
Bartley, Jim |
|
dc.contributor.author |
Waayer, Debbie |
|
dc.contributor.author |
Lawes, Carlene MM |
|
dc.contributor.author |
Toop, Les |
|
dc.contributor.author |
Khaw, Kay-Tee |
|
dc.contributor.author |
Scragg, Robert |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2021-09-14T21:57:41Z |
|
dc.date.available |
2021-09-14T21:57:41Z |
|
dc.date.issued |
2018-6 |
|
dc.identifier.issn |
0304-3959 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/56541 |
|
dc.description.abstract |
Observational studies suggest that vitamin D deficiency is associated with higher risk of pain. However, evidence on the effect of vitamin D supplementation on pain is limited and contradictory. The aim of this study was to compare the effect of monthly high-dose vitamin D supplementation on a pain impact questionnaire (PIQ-6) score and prescription of analgesics in the general population. We performed a randomized, double-blind, placebo-controlled trial of 5108 community-dwelling participants, aged 50 to 84 years, who were randomly assigned to receive monthly 100,000-IU capsules of vitamin D3 (n = 2558) or placebo (n = 2550) for a median of 3.3 years. The PIQ-6 was administered at baseline, year 1, and final follow-up. Analgesic prescription data were collected from Ministry of Health. There was no difference in mean PIQ-6 score at the end of follow-up (adjusted mean difference: 0.06; P = 0.82) between the vitamin D (n = 2041) and placebo (n = 2014) participants. The proportion of participants dispensed one or more opioids was similar in the vitamin D group (n = 559, 21.9%) compared with placebo (n = 593, 23.3%); the relative risk (RR) adjusted for age, sex, and ethnicity was 0.94 (P = 0.24). Similar results were observed for dispensing of nonsteroidal anti-inflammatory drugs (RR = 0.94; P = 0.24) and other nonopioids (RR = 0.98; P = 0.34). Focusing on vitamin D deficient participants (<50 nmol/L, 24.9%), there was a lower risk of dispensing nonsteroidal anti-inflammatory drugs in the vitamin D group compared with placebo (RR = 0.87; P = 0.009); all other subgroup analyses were not significant. Long-term monthly high-dose vitamin D supplementation did not improve mean PIQ-6 score or reduce analgesic dispensing in the general population. |
|
dc.format.medium |
Print |
|
dc.language |
eng |
|
dc.publisher |
Ovid Technologies (Wolters Kluwer Health) |
|
dc.relation.ispartofseries |
Pain |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Humans |
|
dc.subject |
Pain |
|
dc.subject |
Vitamin D |
|
dc.subject |
Analgesics |
|
dc.subject |
Treatment Outcome |
|
dc.subject |
Follow-Up Studies |
|
dc.subject |
Double-Blind Method |
|
dc.subject |
Dietary Supplements |
|
dc.subject |
Aged |
|
dc.subject |
Aged, 80 and over |
|
dc.subject |
Middle Aged |
|
dc.subject |
Female |
|
dc.subject |
Male |
|
dc.subject |
Drug Prescriptions |
|
dc.subject |
Independent Living |
|
dc.subject |
Surveys and Questionnaires |
|
dc.subject |
Aged |
|
dc.subject |
Aged, 80 and over |
|
dc.subject |
Analgesics |
|
dc.subject |
Dietary Supplements |
|
dc.subject |
Double-Blind Method |
|
dc.subject |
Drug Prescriptions |
|
dc.subject |
Female |
|
dc.subject |
Follow-Up Studies |
|
dc.subject |
Humans |
|
dc.subject |
Independent Living |
|
dc.subject |
Male |
|
dc.subject |
Middle Aged |
|
dc.subject |
Pain |
|
dc.subject |
Surveys and Questionnaires |
|
dc.subject |
Treatment Outcome |
|
dc.subject |
Vitamin D |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Anesthesiology |
|
dc.subject |
Clinical Neurology |
|
dc.subject |
Neurosciences |
|
dc.subject |
Neurosciences & Neurology |
|
dc.subject |
Vitamin D supplementation |
|
dc.subject |
Pain |
|
dc.subject |
Analgesics |
|
dc.subject |
Randomized controlled trial |
|
dc.subject |
NONSTEROIDAL ANTIINFLAMMATORY DRUGS |
|
dc.subject |
D DEFICIENCY |
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dc.subject |
CARTILAGE VOLUME |
|
dc.subject |
KNEE PAIN |
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dc.subject |
OSTEOARTHRITIS |
|
dc.subject |
PROGRESSION |
|
dc.subject |
PREVALENCE |
|
dc.subject |
CANCER |
|
dc.subject |
RISK |
|
dc.subject |
1117 Public Health and Health Services |
|
dc.subject |
Clinical |
|
dc.subject |
Clinical Medicine and Science |
|
dc.subject |
Clinical Research |
|
dc.subject |
Pain Conditions - Chronic |
|
dc.subject |
Pain Research |
|
dc.subject |
Complementary and Alternative Medicine |
|
dc.subject |
Clinical Trials and Supportive Activities |
|
dc.subject |
Nutrition |
|
dc.subject |
Prevention |
|
dc.subject |
6.1 Pharmaceuticals |
|
dc.subject |
3.3 Nutrition and chemoprevention |
|
dc.subject |
11 Medical and Health Sciences |
|
dc.subject |
17 Psychology and Cognitive Sciences |
|
dc.title |
Monthly vitamin D supplementation, pain, and pattern of analgesic prescription: secondary analysis from the randomized, double-blind, placebo-controlled Vitamin D Assessment study. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1097/j.pain.0000000000001189 |
|
pubs.issue |
6 |
|
pubs.begin-page |
1074 |
|
pubs.volume |
159 |
|
dc.date.updated |
2021-08-19T03:43:40Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/29494417 |
|
pubs.end-page |
1082 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Randomized Controlled Trial |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
728239 |
|
dc.identifier.eissn |
1872-6623 |
|
dc.identifier.pii |
00006396-201806000-00011 |
|
pubs.online-publication-date |
2018-2-24 |
|