dc.contributor.author |
Lovell, Amy L |
|
dc.contributor.author |
Milne, Tania |
|
dc.contributor.author |
Matsuyama, Misa |
|
dc.contributor.author |
Hill, Rebecca J |
|
dc.contributor.author |
Davies, Peter SW |
|
dc.contributor.author |
Grant, Cameron C |
|
dc.contributor.author |
Wall, Clare R |
|
dc.coverage.spatial |
Switzerland |
|
dc.date.accessioned |
2021-09-19T23:16:08Z |
|
dc.date.available |
2021-09-19T23:16:08Z |
|
dc.date.issued |
2021-1 |
|
dc.identifier.citation |
Frontiers in nutrition 8:666228 Jan 2021 |
|
dc.identifier.issn |
2296-861X |
|
dc.identifier.uri |
https://hdl.handle.net/2292/56586 |
|
dc.description.abstract |
The relationship of protein intake with insulin-like growth factor 1 (IGF-1) concentrations in well-nourished children during the second year of life is poorly understood. The aim of this study was to explore the effect of a reduced-protein Growing Up Milk Lite (GUMLi) or unfortified cow's milk (CM) on protein intake, growth, and plasma IGF-1 at 2 y. An exploratory analysis of a sub-sample of Auckland-based children (<i>n</i> = 79) in the GUMLi trial (a double-blind, randomised control trial, <i>N</i> = 160) completed in Auckland and Brisbane (2015-2017) was conducted. One-year old children were randomised to receive a reduced-protein GUMLi (1.7 g protein/100 mL) or a non-fortified CM (3.1 g protein/100 mL) for 12 months. Blood sampling and anthropometric measurements were made at 1 and 2 y. Diet was assessed using a validated food frequency questionnaire. Total protein intake (g/d) from all cow's milk sources was 4.6 g (95% CI: -6.7, -2.4; <i>p</i> < 0.005) lower in the GUMLi group after 12 months of the intervention, with a significant group-by-time interaction (<i>p</i> = 0.005). Length-for-age (LAZ) and weight-for-length (WLZ) <i>z</i>-scores did not differ between groups, however, mean body fat % (BF%) was 3.2% (95%CI: -6.2, -0.3; <i>p</i> = 0.032) lower in the GUMLi group at 2 y. There was no difference between the intervention groups in relation to IGF-1 and IGF-BP3 (<i>p</i> = 0.894 and 0.698, respectively), with no group-by-sex interaction. After combining the groups, IGF-1 concentration at 2 y was positively correlated with parameters of growth (all <i>p</i> < 0.05), total cow's milk intake (<i>p</i> = 0.032) after adjusting for sex, breastfeeding status, and gestation. Randomisation to a reduced protein GUMLi resulted in small reduction in %BF and lower total protein intakes but had no effect on growth. Plasma IGF-1 concentrations were independently associated with total protein intake from cow's milk at 2 y, highlighting a potential area of the diet to target when designing future protein-related nutrition interventions. <b>Clinical Trial Registration:</b> Australian New Zealand Clinical Trials Registry number: ACTRN12614000918628. Date registered: 27/08/2014. |
|
dc.format.medium |
Electronic-eCollection |
|
dc.language |
eng |
|
dc.publisher |
Frontiers Media SA |
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dc.relation.ispartofseries |
Frontiers in nutrition |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
IGF-1 |
|
dc.subject |
Young Child Formula |
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dc.subject |
cow's milk |
|
dc.subject |
growing-up milk |
|
dc.subject |
growth |
|
dc.subject |
young children |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Nutrition & Dietetics |
|
dc.subject |
cow's milk |
|
dc.subject |
Young Child Formula |
|
dc.subject |
growing-up milk |
|
dc.subject |
young children |
|
dc.subject |
IGF-1 |
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dc.subject |
growth |
|
dc.subject |
BODY-MASS INDEX |
|
dc.subject |
INFANT FORMULA |
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dc.subject |
FOLLOW-UP |
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dc.subject |
OBESITY RISK |
|
dc.subject |
AGE |
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dc.subject |
ASSOCIATION |
|
dc.subject |
CHILDHOOD |
|
dc.subject |
NUTRITION |
|
dc.subject |
INSULIN |
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dc.subject |
FAT |
|
dc.subject |
1001 Agricultural Biotechnology |
|
dc.subject |
1111 Nutrition and Dietetics |
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dc.title |
Protein Intake, IGF-1 Concentrations, and Growth in the Second Year of Life in Children Receiving Growing Up Milk - Lite (GUMLi) or Cow's Milk (CM) Intervention. |
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dc.type |
Journal Article |
|
dc.identifier.doi |
10.3389/fnut.2021.666228 |
|
pubs.begin-page |
666228 |
|
pubs.volume |
8 |
|
dc.date.updated |
2021-08-18T03:13:03Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/34179057 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Case Reports |
|
pubs.subtype |
case-report |
|
pubs.elements-id |
858679 |
|
dc.identifier.eissn |
2296-861X |
|
pubs.number |
ARTN 666228 |
|
pubs.online-publication-date |
2021-6-10 |
|