FAIR Models of Atrial Cellular Electrophysiology

Abstract

Throughout history, there has been a search to improve the understanding of human cardiac physiology and pathophysiology. This search has been carried out by numerous researchers and scientists, all engaging in the question from different angles. It is the goal of this research project to study models of atrial cellular electrophysiology from published literature using OpenCOR, CellML and the Physiome Model Repository to aid in this process. This was done by increasing the findability, accessibility, interoperability, and reusability (FAIR) of these tools. Results from this research show that there is a high level of modularity in the interdependent models available on the Physiome Model Repository, whose modules can be used interchangeably to create new to customised models for researchers to study and increase their understanding of human atrial cardiomyocytes. This method can be applied to other models on the Physiome Model Repository, and further implementation of modularity across published models would accelerate the process of ultimately using mathematical models in clinical environments to aid physicians in their jobs to diagnose and treat patients.