Incidence and investigation of potential risk-factors for clozapine-associated myocarditis and cardiomyopathy in a New Zealand cohort.

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dc.contributor.author Bellissima, Brandi L
dc.contributor.author Vara, Alisha
dc.contributor.author Helsby, Nuala
dc.contributor.author Garavan, Fintan
dc.contributor.author Tingle, Malcolm D
dc.coverage.spatial Ireland
dc.date.accessioned 2021-09-26T20:47:50Z
dc.date.available 2021-09-26T20:47:50Z
dc.date.issued 2021-5
dc.identifier.issn 0165-1781
dc.identifier.uri https://hdl.handle.net/2292/56669
dc.description.abstract Clozapine is a uniquely effective antipsychotic indicated for treatment-resistant schizophrenia. However, its use is underutilised and often delayed for years due to potential adverse reactions including myocarditis and cardiomyopathy. The purpose of this study was to conduct a retrospective review of the clinical records of patients initiating clozapine in the Auckland District Health Board (ADHB) region to determine the incidence of clozapine-associated myocarditis and cardiomyopathy and to identify potential risk factors associated with these cardiotoxicities. The incidence of clozapine-associated myocarditis and cardiomyopathy over a two-year period in the ADHB region was 3.8% and 1.3% respectively.
dc.format.medium Print-Electronic
dc.language eng
dc.publisher Elsevier BV
dc.relation.ispartofseries Psychiatry research
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.subject cardiomyopathy
dc.subject clozapine
dc.subject incidence
dc.subject myocarditis
dc.subject risk factors
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Psychiatry
dc.subject clozapine
dc.subject myocarditis
dc.subject cardiomyopathy
dc.subject incidence
dc.subject risk factors
dc.subject PRACTICE GUIDELINES
dc.subject HEART
dc.subject SCHIZOPHRENIA
dc.subject COMMITTEE
dc.subject 11 Medical and Health Sciences
dc.subject 17 Psychology and Cognitive Sciences
dc.title Incidence and investigation of potential risk-factors for clozapine-associated myocarditis and cardiomyopathy in a New Zealand cohort.
dc.type Journal Article
dc.identifier.doi 10.1016/j.psychres.2021.113873
pubs.begin-page 113873
pubs.volume 299
dc.date.updated 2021-08-16T04:00:26Z
dc.rights.holder Copyright: The author en
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/33799127
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/RetrictedAccess en
pubs.subtype Journal Article
pubs.elements-id 844672
dc.identifier.eissn 1872-7123
dc.identifier.pii S0165-1781(21)00170-0
pubs.number 113873


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