dc.contributor.author |
Lin, Luling |
|
dc.contributor.author |
Crowther, Caroline |
|
dc.contributor.author |
Gamble, Greg |
|
dc.contributor.author |
Bloomfield, Frank |
|
dc.contributor.author |
Harding, Jane E |
|
dc.contributor.author |
ESSENCE IPD-MA Group |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2021-11-08T21:31:35Z |
|
dc.date.available |
2021-11-08T21:31:35Z |
|
dc.date.issued |
2020-1-8 |
|
dc.identifier.citation |
BMJ open 10(1):e033438 08 Jan 2020 |
|
dc.identifier.issn |
2044-6055 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/57306 |
|
dc.description.abstract |
<h4>Introduction</h4>Preterm and small for gestational age (SGA) infants are at increased risk of poor growth, disability and delayed development. While growing up they are also at increased risk of obesity, diabetes and later heart disease. The risk of such adverse outcomes may be altered by how preterm and SGA infants are fed after birth. Faltering postnatal growth is common due to failure to achieve recommended high energy and protein intakes, and thus preterm and SGA infants are often provided with supplemental nutrition soon after birth. Enhanced nutrition has been associated with improved early growth and better cognitive development. However, limited evidence suggests that faster growth may increase the risk for later adiposity, metabolic and cardiovascular disease, and that such risks may differ between girls and boys.<h4>Methods and analysis</h4>We will search Ovid MEDLINE, Embase, Cochrane CENTRAL, Cochrane Database of Systematic Reviews, controlled-trials.com, ClinicalTrials.gov and anzctr.org.au for randomised trials that studied the effects of macronutrient supplements for preterm and SGA infants on (i) developmental and metabolic and (ii) growth outcomes after hospital discharge. The outcomes will be (i) cognitive impairment and metabolic risk (co-primary) and (ii) body mass index. Individual participant data (IPD) from all available trials will be included using an intention-to-treat approach. A one-stage procedure for IPD meta-analysis (MA) will be used, accounting for clustering of participants within studies. Exploratory subgroup analyses will further investigate sources of heterogeneity, including sex and size of infants, different timing, duration and type of supplements.<h4>Ethics and dissemination</h4>This IPD-MA is approved by the University of Auckland Human Participants Ethics Committee (reference number: 019874). Individual studies have approval from relevant local ethics committees. Results will be disseminated in a peer-reviewed journal and presented at international conferences.<h4>Prospero registration number</h4>CRD42017072683. |
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dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
BMJ |
|
dc.relation.ispartofseries |
BMJ open |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc/4.0/ |
|
dc.subject |
ESSENCE IPD-MA Group |
|
dc.subject |
Humans |
|
dc.subject |
Infant, Premature, Diseases |
|
dc.subject |
Dietary Supplements |
|
dc.subject |
Infant, Newborn |
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dc.subject |
Infant, Small for Gestational Age |
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dc.subject |
development |
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dc.subject |
individual participant data meta-analysis |
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dc.subject |
metabolic |
|
dc.subject |
preterm |
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dc.subject |
small-for-gestational-age |
|
dc.subject |
Dietary Supplements |
|
dc.subject |
Humans |
|
dc.subject |
Infant, Newborn |
|
dc.subject |
Infant, Premature, Diseases |
|
dc.subject |
Infant, Small for Gestational Age |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Medicine, General & Internal |
|
dc.subject |
General & Internal Medicine |
|
dc.subject |
preterm |
|
dc.subject |
small-for-gestational-age |
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dc.subject |
development |
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dc.subject |
metabolic |
|
dc.subject |
individual participant data meta-analysis |
|
dc.subject |
HUMAN-MILK |
|
dc.subject |
GROWTH |
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dc.subject |
OUTCOMES |
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dc.subject |
TRIAL |
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dc.subject |
1114 Paediatrics and Reproductive Medicine |
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dc.subject |
Population & Society |
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dc.subject |
Clinical Medicine and Science |
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dc.subject |
Prevention |
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dc.subject |
Clinical Trials and Supportive Activities |
|
dc.subject |
Nutrition |
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dc.subject |
Preterm, Low Birth Weight and Health of the Newborn |
|
dc.subject |
Infant Mortality |
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dc.subject |
Cardiovascular |
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dc.subject |
Perinatal Period - Conditions Originating in Perinatal Period |
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dc.subject |
Clinical Research |
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dc.subject |
Obesity |
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dc.subject |
Pediatric |
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dc.subject |
Reproductive Health and Childbirth |
|
dc.subject |
Metabolic and Endocrine |
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dc.subject |
Cardiovascular |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
1117 Public Health and Health Services |
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dc.subject |
1199 Other Medical and Health Sciences |
|
dc.title |
Sex-specific effects of nutritional supplements in infants born early or small: protocol for an individual participant data meta-analysis (ESSENCE IPD-MA). |
|
dc.type |
Journal Article |
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dc.identifier.doi |
10.1136/bmjopen-2019-033438 |
|
pubs.issue |
1 |
|
pubs.begin-page |
e033438 |
|
pubs.volume |
10 |
|
dc.date.updated |
2021-10-18T20:50:16Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/31919126 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Meta-Analysis |
|
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
research-article |
|
pubs.subtype |
Review |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
793265 |
|
dc.identifier.eissn |
2044-6055 |
|
dc.identifier.pii |
bmjopen-2019-033438 |
|
pubs.number |
ARTN e033438 |
|
pubs.online-publication-date |
2020-1-8 |
|