Charting elimination in the pandemic: a SARS-CoV-2 serosurvey of blood donors in New Zealand

Show simple item record Carlton, Lauren H Chen, Tiffany Whitcombe, Alana L McGregor, Reuben Scheurich, Greg Sheen, Campbell R Dickson, James M Bullen, Chris Chiang, Annie Exeter, Daniel J Paynter, Janine Baker, Michael G Charlewood, Richard Moreland, Nicole J 2021-11-08T22:54:51Z 2021-11-08T22:54:51Z 2021-7-30
dc.identifier.citation Epidemiology and infection 149:e173 30 Jul 2021
dc.identifier.issn 0950-2688
dc.description.abstract <jats:title>Abstract</jats:title> <jats:p>New Zealand has a strategy of eliminating SARS-CoV-2 that has resulted in a low incidence of reported coronavirus-19 disease (COVID-19). The aim of this study was to describe the spread of SARS-CoV-2 in New Zealand via a nationwide serosurvey of blood donors. Samples (<jats:italic>n</jats:italic> = 9806) were collected over a month-long period (3 December 2020–6 January 2021) from donors aged 16–88 years. The sample population was geographically spread, covering 16 of 20 district health board regions. A series of Spike-based immunoassays were utilised, and the serological testing algorithm was optimised for specificity given New Zealand is a low prevalence setting. Eighteen samples were seropositive for SARS-CoV-2 antibodies, six of which were retrospectively matched to previously confirmed COVID-19 cases. A further four were from donors that travelled to settings with a high risk of SARS-CoV-2 exposure, suggesting likely infection outside New Zealand. The remaining eight seropositive samples were from seven different district health regions for a true seroprevalence estimate, adjusted for test sensitivity and specificity, of 0.103% (95% confidence interval, 0.09–0.12%). The very low seroprevalence is consistent with limited undetected community transmission and provides robust, serological evidence to support New Zealand's successful elimination strategy for COVID-19.</jats:p>
dc.language en
dc.publisher Cambridge University Press (CUP)
dc.relation.ispartofseries Epidemiology and Infection
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Public, Environmental & Occupational Health
dc.subject Infectious Diseases
dc.subject COVID-19
dc.subject elimination
dc.subject New Zealand
dc.subject receptor binding domain
dc.subject SARS-CoV-2
dc.subject seroprevalence
dc.subject serosurvey
dc.subject Spike
dc.subject ANTIBODIES
dc.subject 1117 Public Health and Health Services
dc.title Charting elimination in the pandemic: a SARS-CoV-2 serosurvey of blood donors in New Zealand
dc.type Journal Article
dc.identifier.doi 10.1017/s0950268821001643
pubs.begin-page e173
pubs.volume 149 2021-10-21T22:37:46Z
dc.rights.holder Copyright: The author en
pubs.publication-status Published
dc.rights.accessrights en
pubs.subtype Article
pubs.subtype Journal
pubs.elements-id 862439
dc.identifier.eissn 1469-4409
pubs.number e173 2021-7-30

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