No evidence of abnormal metabolic or inflammatory activity in the brains of patients with rheumatoid arthritis: results from a preliminary study using whole-brain magnetic resonance spectroscopic imaging (MRSI).

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dc.contributor.author Mueller, Christina
dc.contributor.author Lin, Joanne C
dc.contributor.author Thannickal, Halle H
dc.contributor.author Daredia, Altamish
dc.contributor.author Denney, Thomas S
dc.contributor.author Beyers, Ronald
dc.contributor.author Younger, Jarred W
dc.coverage.spatial Germany
dc.date.accessioned 2021-11-14T03:44:32Z
dc.date.available 2021-11-14T03:44:32Z
dc.date.issued 2020-6
dc.identifier.citation Clinical rheumatology 39(6):1765-1774 Jun 2020
dc.identifier.issn 0770-3198
dc.identifier.uri https://hdl.handle.net/2292/57410
dc.description.abstract <h4>Introduction/objectives</h4>Many individuals with rheumatoid arthritis (RA) report persistent fatigue even after management of peripheral disease activity. This study used whole-brain magnetic resonance spectroscopic imaging (MRSI) to investigate whether abnormal inflammatory activity in the central nervous system may be associated with such symptoms. We hypothesized that RA patients would show higher brain choline (CHO), myo-inositol (MI), and lactate (LAC), and higher brain temperature than healthy controls. We further hypothesized that the metabolite levels would be positively correlated with self-reported fatigue.<h4>Method</h4>Thirteen women with RA provided fatigue severity ratings and underwent whole-brain MRSI and a joint examination. Thirteen healthy controls (HC) provided comparison imaging and fatigue data. CHO, MI, LAC, and brain temperature in 47 brain regions were contrasted between groups using independent-samples t tests. Significant differences were determined using a false discovery rate (FDR)-adjusted p value threshold of ≤ 0.0023. Secondary analyses obtained correlations between imaging and clinical outcomes in the RA group.<h4>Results</h4>No brain metabolic differences were identified between the groups. In the RA group, fatigue severity was positively correlated with CHO in several brain regions-most strongly the right frontal lobe (r<sub>s</sub> = 0.823, p < 0.001). MI was similarly correlated with fatigue, particularly in the right calcarine fissure (r<sub>s</sub> = 0.829, p < 0.001). CHO in several regions was positively correlated with joint swelling and tenderness.<h4>Conclusions</h4>We conclude that abnormal brain metabolites are not a common feature of RA, but may been seen in patients with persistent fatigue or disease activity after conventional treatment.Key Points• Whole-brain magnetic resonance spectroscopy revealed no metabolic abnormalities in the brain in patients with rheumatoid arthritis.• Brain choline levels were correlated with fatigue severity reported by RA patients and with peripheral joint swelling and tenderness.• Brain myo-inositol levels were similarly correlated with fatigue severity in RA patients.
dc.format.medium Print-Electronic
dc.language eng
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartofseries Clinical rheumatology
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Brain
dc.subject Humans
dc.subject Arthritis, Rheumatoid
dc.subject Choline
dc.subject Inositol
dc.subject Lactic Acid
dc.subject Magnetic Resonance Imaging
dc.subject Magnetic Resonance Spectroscopy
dc.subject Case-Control Studies
dc.subject Adult
dc.subject Middle Aged
dc.subject Female
dc.subject Male
dc.subject Brain metabolites
dc.subject Brain temperature
dc.subject Magnetic resonance spectroscopy
dc.subject Rheumatoid arthritis
dc.subject Adult
dc.subject Arthritis, Rheumatoid
dc.subject Brain
dc.subject Case-Control Studies
dc.subject Choline
dc.subject Female
dc.subject Humans
dc.subject Inositol
dc.subject Lactic Acid
dc.subject Magnetic Resonance Imaging
dc.subject Magnetic Resonance Spectroscopy
dc.subject Male
dc.subject Middle Aged
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Rheumatology
dc.subject Brain metabolites
dc.subject Brain temperature
dc.subject Magnetic resonance spectroscopy
dc.subject Rheumatoid arthritis
dc.subject HOSPITAL ANXIETY
dc.subject DISEASE-ACTIVITY
dc.subject TEMPERATURE
dc.subject FATIGUE
dc.subject ACETYLASPARTATE
dc.subject MODULATION
dc.subject MICROGLIA
dc.subject CYTOKINES
dc.subject PROFILES
dc.subject DRUGS
dc.subject 1103 Clinical Sciences
dc.subject 1109 Neurosciences
dc.subject Clinical
dc.subject Clinical Medicine and Science
dc.subject Autoimmune Disease
dc.subject Neurosciences
dc.subject Rheumatoid Arthritis
dc.subject Biomedical Imaging
dc.subject Brain Disorders
dc.subject Clinical Research
dc.subject Arthritis
dc.subject Inflammatory and Immune System
dc.subject 2.1 Biological and endogenous factors
dc.subject 1103 Clinical Sciences
dc.title No evidence of abnormal metabolic or inflammatory activity in the brains of patients with rheumatoid arthritis: results from a preliminary study using whole-brain magnetic resonance spectroscopic imaging (MRSI).
dc.type Journal Article
dc.identifier.doi 10.1007/s10067-019-04923-5
pubs.issue 6
pubs.begin-page 1765
pubs.volume 39
dc.date.updated 2021-10-26T00:48:56Z
dc.rights.holder Copyright: The author en
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/32002761
pubs.end-page 1774
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype research-article
pubs.subtype Journal Article
pubs.elements-id 793929
dc.identifier.eissn 1434-9949
dc.identifier.pii 10.1007/s10067-019-04923-5
pubs.online-publication-date 2020-1-30


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