dc.contributor.author |
Gamage, Teena KJB |
|
dc.contributor.author |
Fraser, Mhoyra |
|
dc.coverage.spatial |
Switzerland |
|
dc.date.accessioned |
2021-11-16T22:01:14Z |
|
dc.date.available |
2021-11-16T22:01:14Z |
|
dc.date.issued |
2021-1 |
|
dc.identifier.citation |
Frontiers in neuroscience 15:744840 Jan 2021 |
|
dc.identifier.issn |
1662-4548 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/57463 |
|
dc.description.abstract |
This comprehensive review focuses on our current understanding of the proposed physiological and pathological functions of extracellular vesicles (EVs) in the developing brain. Furthermore, since EVs have attracted great interest as potential novel cell-free therapeutics, we discuss advances in the knowledge of stem cell- and astrocyte-derived EVs in relation to their potential for protection and repair following perinatal brain injury. This review identified 13 peer-reviewed studies evaluating the efficacy of EVs in animal models of perinatal brain injury; 12/13 utilized mesenchymal stem cell-derived EVs (MSC-EVs) and 1/13 utilized astrocyte-derived EVs. Animal model, method of EV isolation and size, route, timing, and dose administered varied between studies. Notwithstanding, EV treatment either improved and/or preserved perinatal brain structures both macroscopically and microscopically. Additionally, EV treatment modulated inflammatory responses and improved brain function. Collectively this suggests EVs can ameliorate, or repair damage associated with perinatal brain injury. These findings warrant further investigation to identify the optimal cell numbers, source, and dosage regimens of EVs, including long-term effects on functional outcomes. |
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dc.format.medium |
Electronic-eCollection |
|
dc.language |
eng |
|
dc.publisher |
Frontiers Media SA |
|
dc.relation.ispartofseries |
Frontiers in neuroscience |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
biomarkers |
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dc.subject |
exosomes |
|
dc.subject |
extracellular vesicles |
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dc.subject |
in-vivo animal models |
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dc.subject |
perinatal brain injury |
|
dc.subject |
therapeutic strategies |
|
dc.subject |
white matter injury |
|
dc.subject |
1109 Neurosciences |
|
dc.subject |
1701 Psychology |
|
dc.subject |
1702 Cognitive Sciences |
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dc.title |
The Role of Extracellular Vesicles in the Developing Brain: Current Perspective and Promising Source of Biomarkers and Therapy for Perinatal Brain Injury. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.3389/fnins.2021.744840 |
|
pubs.begin-page |
744840 |
|
pubs.volume |
15 |
|
dc.date.updated |
2021-10-15T17:11:50Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/34630028 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
review-article |
|
pubs.subtype |
Review |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
869858 |
|
dc.identifier.eissn |
1662-453X |
|
pubs.online-publication-date |
2021-9-24 |
|