Modelling uptake and transport of therapeutic agents through the lymphatic system.

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dc.contributor.author Jayathungage Don, TD
dc.contributor.author Suresh, V
dc.contributor.author Cater, JE
dc.contributor.author Clarke, RJ
dc.coverage.spatial England
dc.date.accessioned 2021-11-16T22:17:37Z
dc.date.available 2021-11-16T22:17:37Z
dc.date.issued 2021-10
dc.identifier.citation Computer methods in biomechanics and biomedical engineering 1-14 Oct 2021
dc.identifier.issn 1025-5842
dc.identifier.uri https://hdl.handle.net/2292/57466
dc.description.abstract The ability of the lymphatic network to absorb large molecules and bypass the first-pass liver metabolism makes it appealing as a delivery system for therapeutic substances. In most cases, the drug is injected into the subcutaneous tissue and must negotiate the tissue space, before being drained via the lymphatics. Tracking the transport of drug molecules through this route is challenging, and computational models of lymphatic drainage can play an important role in assessing the efficacy of a proposed delivery strategy. The three-dimensional computational model we present here of the peripheral lymphatic network and surrounding interstitium is informed by anatomical data, and quantifies the degree to which uptake and transit times are affected by drug particle size, physiological flow rates, and specifics of drug injection.
dc.format.medium Print-Electronic
dc.language eng
dc.publisher Informa UK Limited
dc.relation.ispartofseries Computer methods in biomechanics and biomedical engineering
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.rights.uri https://authorservices.taylorandfrancis.com/research-impact/sharing-versions-of-journal-articles/
dc.subject CFD
dc.subject Lymphatic drainage
dc.subject drug delivery
dc.subject needle-free injection
dc.subject 0903 Biomedical Engineering
dc.subject 1105 Dentistry
dc.title Modelling uptake and transport of therapeutic agents through the lymphatic system.
dc.type Journal Article
dc.identifier.doi 10.1080/10255842.2021.1984434
pubs.begin-page 1
dc.date.updated 2021-10-08T18:09:54Z
dc.rights.holder Copyright: Informa UK Limited en
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/34592851
pubs.end-page 14
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/RetrictedAccess en
pubs.subtype Journal Article
pubs.elements-id 869016
dc.identifier.eissn 1476-8259
pubs.online-publication-date 2021-10-1


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