Striatal volume increases in active methamphetamine-dependent individuals and correlation with cognitive performance.

Show simple item record Jan, Reem K Lin, Joanne C Miles, Sylvester W Kydd, Rob R Russell, Bruce R
dc.coverage.spatial Switzerland 2021-11-18T22:30:52Z 2021-11-18T22:30:52Z 2012-10-30
dc.identifier.citation Brain sciences 2(4):553-572 30 Oct 2012
dc.identifier.issn 2076-3425
dc.description.abstract The effect of methamphetamine (MA) dependence on the structure of the human brain has not been extensively studied, especially in active users. Previous studies reported cortical deficits and striatal gains in grey matter (GM) volume of abstinent MA abusers compared with control participants. This study aimed to investigate structural GM changes in the brains of 17 active MA-dependent participants compared with 20 control participants aged 18-46 years using voxel-based morphometry and region of interest volumetric analysis of structural magnetic resonance imaging data, and whether these changes might be associated with cognitive performance. Significant volume increases were observed in the right and left putamen and left nucleus accumbens of MA-dependent compared to control participants. The volumetric gain in the right putamen remained significant after Bonferroni correction, and was inversely correlated with the number of errors (standardised z-scores) on the Go/No-go task. MA-dependent participants exhibited cortical GM deficits in the left superior frontal and precentral gyri in comparison to control participants, although these findings did not survive correction for multiple comparisons. In conclusion, consistent with findings from previous studies of abstinent users, active chronic MA-dependent participants showed significant striatal enlargement which was associated with improved performance on the Go/No-go, a cognitive task of response inhibition and impulsivity. Striatal enlargement may reflect the involvement of neurotrophic effects, inflammation or microgliosis. However, since it was associated with improved cognitive function, it is likely to reflect a compensatory response to MA-induced neurotoxicity in the striatum, in order to maintain cognitive function. Follow-up studies are recommended to ascertain whether this effect continues to be present following abstinence. Several factors may have contributed to the lack of more substantial cortical and subcortical GM changes amongst MA-dependent participants, including variability in MA exposure variables and difference in abstinence status from previous studies.
dc.format.medium Electronic
dc.language eng
dc.publisher MDPI AG
dc.relation.ispartofseries Brain sciences
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.subject 1701 Psychology
dc.subject Clinical
dc.subject Clinical Research
dc.subject Basic Behavioral and Social Science
dc.subject Brain Disorders
dc.subject Drug Abuse (NIDA Only)
dc.subject Substance Abuse
dc.subject Behavioral and Social Science
dc.subject Neurosciences
dc.subject Methamphetamine
dc.subject Mental Health
dc.subject 1109 Neurosciences
dc.subject 1701 Psychology
dc.subject 1702 Cognitive Sciences
dc.title Striatal volume increases in active methamphetamine-dependent individuals and correlation with cognitive performance.
dc.type Journal Article
dc.identifier.doi 10.3390/brainsci2040553
pubs.issue 4
pubs.begin-page 553
pubs.volume 2 2021-10-26T00:51:48Z
dc.rights.holder Copyright: The author en
pubs.end-page 572
pubs.publication-status Published
dc.rights.accessrights en
pubs.subtype research-article
pubs.subtype Journal Article
pubs.elements-id 389977
dc.identifier.eissn 2076-3425
dc.identifier.pii brainsci2040553 2012-10-30

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