dc.contributor.author |
Harris, Deborah L |
|
dc.contributor.author |
Weston, Philip J |
|
dc.contributor.author |
Harding, Jane E |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2021-12-08T22:43:14Z |
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dc.date.available |
2021-12-08T22:43:14Z |
|
dc.date.issued |
2021-4 |
|
dc.identifier.issn |
0022-3476 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/57704 |
|
dc.description.abstract |
<h4>Objectives</h4>To determine plasma lactate and beta-hydroxybutyrate (BHB) concentrations of healthy infants in the first 5 days and their relationships with glucose concentrations.<h4>Study design</h4>Prospective masked observational study in Hamilton, New Zealand. Term, appropriately grown singletons had heel-prick blood samples, 4 in the first 24 hours then twice daily.<h4>Results</h4>In 67 infants, plasma lactate concentrations were higher in the first 12 hours (median, 20; range, 10-55 mg/dL [median, 2.2 mmol/L; range, 1.1-6.2 mmol/L]), decreasing to 12 mg/dL (range, 7-29 mg/dL [median, 1.4 mmol/L; range, 0.8-3.3 mmol/L]) after 48 hours. Plasma BHB concentrations were low in the first 12 hours (median, 0.9 mg/dL; range, 0.5-5.2 mg/dL [median, 0.1 mmol/L; range, 0.05-0.5 mmol/L]), peaked at 48-72 hours (median, 7.3 mg/dL; range, 1.0-25.0 mg/dL [median, 0.7 mmol/L; range, 0.05-2.4 mmol/L]), and decreased by 96 hours (median, 0.9 mg/dL; range, 0.5-16.7 mg/dL [median, 0.1 mmol/L; range, 0.05-1.6 mmol/L]). Compared with infants with plasma glucose concentrations above the median (median, 67 mg/dL [median, 3.7 mmol/L]), those with lower glucose had lower lactate concentrations in the first 12 hours and higher BHB concentrations between 24 and 96 hours. Lower interstitial glucose concentrations were also associated with higher plasma BHB concentrations, but only if the lower glucose lasted greater than 12 hours. Glucose contributed 72%-84% of the estimated potential adenosine triphosphate throughout the 5 days, with lactate contributing 25% on day 1 and BHB 7% on days 2-3.<h4>Conclusions</h4>Lactate on day 1 and BHB on days 2-4 may contribute to cerebral fuels in healthy infants, but are unlikely to provide neuroprotection during early or acute hypoglycemia.<h4>Trial registration</h4>The Australian and New Zealand Clinical Trials Registry: ACTRN12615000986572. |
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dc.format.medium |
Print-Electronic |
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dc.language |
eng |
|
dc.publisher |
Elsevier BV |
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dc.relation.ispartofseries |
The Journal of pediatrics |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
Brain |
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dc.subject |
Humans |
|
dc.subject |
Hypoglycemia |
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dc.subject |
3-Hydroxybutyric Acid |
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dc.subject |
Lactic Acid |
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dc.subject |
Blood Glucose |
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dc.subject |
Prospective Studies |
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dc.subject |
Single-Blind Method |
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dc.subject |
Infant, Newborn |
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dc.subject |
Female |
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dc.subject |
Male |
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dc.subject |
Biomarkers |
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dc.subject |
beta-hydroxybutyrate |
|
dc.subject |
continuous glucose monitoring |
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dc.subject |
glucose |
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dc.subject |
hypoglycemia |
|
dc.subject |
infant |
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dc.subject |
lactate |
|
dc.subject |
metabolic adaptation |
|
dc.subject |
newborn |
|
dc.subject |
3-Hydroxybutyric Acid |
|
dc.subject |
Biomarkers |
|
dc.subject |
Blood Glucose |
|
dc.subject |
Brain |
|
dc.subject |
Female |
|
dc.subject |
Humans |
|
dc.subject |
Hypoglycemia |
|
dc.subject |
Infant, Newborn |
|
dc.subject |
Lactic Acid |
|
dc.subject |
Male |
|
dc.subject |
Prospective Studies |
|
dc.subject |
Single-Blind Method |
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dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
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dc.subject |
Pediatrics |
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dc.subject |
1106 Human Movement and Sports Sciences |
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dc.subject |
1114 Paediatrics and Reproductive Medicine |
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dc.title |
Alternative Cerebral Fuels in the First Five Days in Healthy Term Infants: The Glucose in Well Babies (GLOW) Study. |
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dc.type |
Journal Article |
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dc.identifier.doi |
10.1016/j.jpeds.2020.12.063 |
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pubs.begin-page |
81 |
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pubs.volume |
231 |
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dc.date.updated |
2021-11-11T17:32:05Z |
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dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33373670 |
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pubs.end-page |
86.e2 |
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pubs.publication-status |
Published |
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dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
Journal Article |
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pubs.subtype |
Observational Study |
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pubs.elements-id |
833933 |
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dc.identifier.eissn |
1097-6833 |
|
dc.identifier.pii |
S0022-3476(20)31573-0 |
|