dc.contributor.author |
Her, Emily J |
|
dc.contributor.author |
Haworth, Annette |
|
dc.contributor.author |
Sun, Yu |
|
dc.contributor.author |
Williams, Scott |
|
dc.contributor.author |
Reynolds, Hayley M |
|
dc.contributor.author |
Kennedy, Angel |
|
dc.contributor.author |
Ebert, Martin A |
|
dc.coverage.spatial |
Switzerland |
|
dc.date.accessioned |
2021-12-12T23:41:59Z |
|
dc.date.available |
2021-12-12T23:41:59Z |
|
dc.date.issued |
2021-9-29 |
|
dc.identifier.citation |
Cancers 13(19) 29 Sep 2021 |
|
dc.identifier.issn |
2072-6694 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/57744 |
|
dc.description.abstract |
<h4>Purpose</h4>Hypoxia has been linked to radioresistance. Strategies to safely dose escalate dominant intraprostatic lesions have shown promising results, but further dose escalation to overcome the effects of hypoxia require a novel approach to constrain the dose in normal tissue.to safe levels. In this study, we demonstrate a biologically targeted radiotherapy (BiRT) approach that can utilise multiparametric magnetic resonance imaging (mpMRI) to target hypoxia for favourable treatment outcomes.<h4>Methods</h4>mpMRI-derived tumour biology maps, developed via a radiogenomics study, were used to generate individualised, hypoxia-targeting prostate IMRT plans using an ultra- hypofractionation schedule. The spatial distribution of mpMRI textural features associated with hypoxia-related genetic profiles was used as a surrogate of tumour hypoxia. The effectiveness of the proposed approach was assessed by quantifying the potential benefit of a general focal boost approach on tumour control probability, and also by comparing the dose to organs at risk (OARs) with hypoxia-guided focal dose escalation (DE) plans generated for five patients.<h4>Results</h4>Applying an appropriately guided focal boost can greatly mitigate the impact of hypoxia. Statistically significant reductions in rectal and bladder dose were observed for hypoxia-targeting, biologically optimised plans compared to isoeffective focal DE plans.<h4>Conclusion</h4>Results of this study suggest the use of mpMRI for voxel-level targeting of hypoxia, along with biological optimisation, can provide a mechanism for guiding focal DE that is considerably more efficient than application of a general, dose-based optimisation, focal boost. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
MDPI AG |
|
dc.relation.ispartofseries |
Cancers |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
hypoxia |
|
dc.subject |
multiparametric MRI |
|
dc.subject |
prostate cancer |
|
dc.subject |
radiogenomics |
|
dc.subject |
tumour control probability |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Oncology |
|
dc.subject |
prostate cancer |
|
dc.subject |
hypoxia |
|
dc.subject |
tumour control probability |
|
dc.subject |
radiogenomics |
|
dc.subject |
multiparametric MRI |
|
dc.subject |
PROSTATE-CANCER |
|
dc.subject |
ALPHA/BETA RATIO |
|
dc.subject |
RADIOTHERAPY |
|
dc.subject |
OPTIMIZATION |
|
dc.subject |
CELLS |
|
dc.subject |
REOXYGENATION |
|
dc.subject |
INTERMEDIATE |
|
dc.subject |
IRRADIATION |
|
dc.subject |
IMPLANTS |
|
dc.subject |
PROMOTES |
|
dc.subject |
1112 Oncology and Carcinogenesis |
|
dc.title |
Biologically Targeted Radiation Therapy: Incorporating Patient-Specific Hypoxia Data Derived from Quantitative Magnetic Resonance Imaging. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.3390/cancers13194897 |
|
pubs.issue |
19 |
|
pubs.begin-page |
4897 |
|
pubs.volume |
13 |
|
dc.date.updated |
2021-11-14T07:56:15Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/34638382 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
869027 |
|
dc.identifier.eissn |
2072-6694 |
|
dc.identifier.pii |
cancers13194897 |
|
pubs.number |
ARTN 4897 |
|
pubs.online-publication-date |
2021-9-29 |
|