dc.contributor.author |
Hamiaux, Cyril |
|
dc.contributor.author |
Drummond, Revel SM |
|
dc.contributor.author |
Luo, Zhiwei |
|
dc.contributor.author |
Lee, Hui Wen |
|
dc.contributor.author |
Sharma, Prachi |
|
dc.contributor.author |
Janssen, Bart J |
|
dc.contributor.author |
Perry, Nigel B |
|
dc.contributor.author |
Denny, William A |
|
dc.contributor.author |
Snowden, Kimberley C |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2022-01-25T20:31:45Z |
|
dc.date.available |
2022-01-25T20:31:45Z |
|
dc.date.issued |
2018-4 |
|
dc.identifier.issn |
0021-9258 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/58056 |
|
dc.description.abstract |
The strigolactone (SL) family of plant hormones regulates a broad range of physiological processes affecting plant growth and development and also plays essential roles in controlling interactions with parasitic weeds and symbiotic fungi. Recent progress elucidating details of SL biosynthesis, signaling, and transport offers many opportunities for discovering new plant-growth regulators via chemical interference. Here, using high-throughput screening and downstream biochemical assays, we identified <i>N</i>-phenylanthranilic acid derivatives as potent inhibitors of the SL receptors from petunia (DAD2), rice (OsD14), and <i>Arabidopsis</i> (AtD14). Crystal structures of DAD2 and OsD14 in complex with inhibitors further provided detailed insights into the inhibition mechanism, and <i>in silico</i> modeling of 19 other plant strigolactone receptors suggested that these compounds are active across a large range of plant species. Altogether, these results provide chemical tools for investigating SL signaling and further define a framework for structure-based approaches to design and validate optimized inhibitors of SL receptors for specific plant targets. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier BV |
|
dc.relation.ispartofseries |
The Journal of biological chemistry |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Arabidopsis |
|
dc.subject |
Petunia |
|
dc.subject |
Receptors, Cell Surface |
|
dc.subject |
Arabidopsis Proteins |
|
dc.subject |
Structure-Activity Relationship |
|
dc.subject |
Models, Molecular |
|
dc.subject |
Computer Simulation |
|
dc.subject |
ortho-Aminobenzoates |
|
dc.subject |
Oryza |
|
dc.subject |
chemical biology |
|
dc.subject |
crystal structure |
|
dc.subject |
hormone receptor |
|
dc.subject |
hydrolase |
|
dc.subject |
inhibition mechanism |
|
dc.subject |
plant hormone |
|
dc.subject |
strigolactone |
|
dc.subject |
strigolactone receptor inhibitor |
|
dc.subject |
Arabidopsis |
|
dc.subject |
Arabidopsis Proteins |
|
dc.subject |
Computer Simulation |
|
dc.subject |
Models, Molecular |
|
dc.subject |
Oryza |
|
dc.subject |
Petunia |
|
dc.subject |
Receptors, Cell Surface |
|
dc.subject |
Structure-Activity Relationship |
|
dc.subject |
ortho-Aminobenzoates |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Biochemistry & Molecular Biology |
|
dc.subject |
F-BOX PROTEIN |
|
dc.subject |
LEAF SENESCENCE |
|
dc.subject |
STRIGA-HERMONTHICA |
|
dc.subject |
PLANT HORMONES |
|
dc.subject |
GERMINATION |
|
dc.subject |
ARABIDOPSIS |
|
dc.subject |
KARRIKIN |
|
dc.subject |
DWARF14 |
|
dc.subject |
GROWTH |
|
dc.subject |
OPTIMIZATION |
|
dc.subject |
0607 Plant Biology |
|
dc.subject |
0601 Biochemistry and Cell Biology |
|
dc.subject |
Biomedical |
|
dc.subject |
Basic Science |
|
dc.subject |
03 Chemical Sciences |
|
dc.subject |
06 Biological Sciences |
|
dc.subject |
11 Medical and Health Sciences |
|
dc.title |
Inhibition of strigolactone receptors by <i>N</i>-phenylanthranilic acid derivatives: Structural and functional insights. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1074/jbc.ra117.001154 |
|
pubs.issue |
17 |
|
pubs.begin-page |
6530 |
|
pubs.volume |
293 |
|
dc.date.updated |
2021-12-15T01:35:51Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/29523686 |
|
pubs.end-page |
6543 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
732173 |
|
dc.identifier.eissn |
1083-351X |
|
dc.identifier.pii |
S0021-9258(20)39750-7 |
|