dc.contributor.author |
Chan, Chih-Hsiang Alexander |
|
dc.contributor.author |
Aghababaie, Zahra |
|
dc.contributor.author |
Paskaranandavadivel, Niranchan |
|
dc.contributor.author |
Avci, Recep |
|
dc.contributor.author |
Cheng, Leo K |
|
dc.contributor.author |
Angeli-Gordon, Timothy R |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2022-02-03T02:28:08Z |
|
dc.date.available |
2022-02-03T02:28:08Z |
|
dc.date.issued |
2021-12 |
|
dc.identifier.citation |
American journal of physiology. Gastrointestinal and liver physiology 321(6):G656-G667 Dec 2021 |
|
dc.identifier.issn |
0193-1857 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/58106 |
|
dc.description.abstract |
Gastric distension is known to affect normal slow-wave activity and gastric function, but links between slow-wave dysrhythmias and stomach function are poorly understood. Low-resolution mapping is unable to capture complex spatial properties of gastric dysrhythmias, necessitating the use of high-resolution mapping techniques. Characterizing the nature of these dysrhythmias has implications in the understanding of postprandial function and the development of new mapping devices. In this two-phase study, we developed and implemented a protocol for measuring electrophysiological responses to gastric distension in porcine experiments. In vivo, serosal high-resolution electrical mapping (256 electrodes; 36 cm<sup>2</sup>) was performed in anaesthetized pigs (<i>n</i> = 11), and slow-wave pattern, velocity, frequency, and amplitude were quantified before, during, and after intragastric distension. <i>Phase I</i> experiments (<i>n</i> = 6) focused on developing and refining the distension mapping methods using a surgically inserted intragastric balloon, with a variety of balloon types and distension protocols. <i>Phase II</i> experiments (<i>n</i> = 5) used barostat-controlled 500-mL isovolumetric distensions of an endoscopically introduced intragastric balloon. Dysrhythmias were consistently induced in all five gastric distensions, using refined distension protocols. Dysrhythmias appeared 23 s (SD = 5 s) after the distension and lasted 129 s (SD = 72 s), which consisted of ectopic propagation originating from the greater curvature in the region of distension. In summary, our results suggest that distension disrupts gastric entrainment, inducing temporary ectopic slow-wave propagation. These results may influence the understanding of the postprandial stomach and electrophysiological effects of gastric interventions.<b>NEW & NOTEWORTHY</b> This study presents the discovery of temporary dysrhythmic ectopic pacemakers in the distal stomach caused by localized gastric distension. Distension-induced dysrhythmias are an interesting physiological phenomenon that can inform the design of new interventional and electrophysiological protocols for both research and the clinic. The observation of distension-induced dysrhythmias also contributes to our understanding of stretch-sensitivity in the gut and may play an important role in normal and abnormal postprandial physiology. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
American Physiological Society |
|
dc.relation.ispartofseries |
American journal of physiology. Gastrointestinal and liver physiology |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Stomach |
|
dc.subject |
Animals |
|
dc.subject |
Sus scrofa |
|
dc.subject |
Gastric Balloon |
|
dc.subject |
Biological Clocks |
|
dc.subject |
Myoelectric Complex, Migrating |
|
dc.subject |
Time Factors |
|
dc.subject |
Female |
|
dc.subject |
Interstitial Cells of Cajal |
|
dc.subject |
dysrhythmia |
|
dc.subject |
electrophysiology |
|
dc.subject |
gastrointestinal |
|
dc.subject |
interstitial cells of Cajal |
|
dc.subject |
stomach |
|
dc.subject |
Animals |
|
dc.subject |
Biological Clocks |
|
dc.subject |
Female |
|
dc.subject |
Gastric Balloon |
|
dc.subject |
Interstitial Cells of Cajal |
|
dc.subject |
Myoelectric Complex, Migrating |
|
dc.subject |
Stomach |
|
dc.subject |
Sus scrofa |
|
dc.subject |
Time Factors |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Gastroenterology & Hepatology |
|
dc.subject |
Physiology |
|
dc.subject |
dysrhythmia |
|
dc.subject |
electrophysiology |
|
dc.subject |
gastrointestinal |
|
dc.subject |
interstitial cells of Cajal |
|
dc.subject |
stomach |
|
dc.subject |
INTERSTITIAL-CELLS |
|
dc.subject |
ANTRAL MOTILITY |
|
dc.subject |
SMOOTH-MUSCLE |
|
dc.subject |
PATTERNS |
|
dc.subject |
ORIGIN |
|
dc.subject |
CAJAL |
|
dc.subject |
CHANNELOPATHIES |
|
dc.subject |
ANESTHESIA |
|
dc.subject |
CONDUCTION |
|
dc.subject |
FREQUENCY |
|
dc.subject |
0606 Physiology |
|
dc.subject |
1116 Medical Physiology |
|
dc.title |
Localized gastric distension disrupts slow-wave entrainment leading to temporary ectopic propagation: a high-resolution electrical mapping study. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1152/ajpgi.00219.2021 |
|
pubs.issue |
6 |
|
pubs.begin-page |
G656 |
|
pubs.volume |
321 |
|
dc.date.updated |
2022-01-09T23:27:47Z |
|
dc.rights.holder |
Copyright: 2021 the American Physiological Society |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/34612062 |
|
pubs.end-page |
G667 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
869872 |
|
dc.identifier.eissn |
1522-1547 |
|