dc.contributor.author |
Bailey, Miranda J |
|
dc.contributor.author |
Rout, Allie |
|
dc.contributor.author |
Harding, Jane E |
|
dc.contributor.author |
Alsweiler, Jane M |
|
dc.contributor.author |
Cutfield, Wayne S |
|
dc.contributor.author |
McKinlay, Christopher JD |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2022-02-16T03:07:04Z |
|
dc.date.available |
2022-02-16T03:07:04Z |
|
dc.date.issued |
2021-5 |
|
dc.identifier.issn |
0743-8346 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/58197 |
|
dc.description.abstract |
<h4>Background</h4>We performed a case-control study to characterise infants with "prolonged transitional hypoglycaemia".<h4>Methods</h4>Cases were born ≥36 weeks' gestation; had ≥1 hypoglycaemic episode <72 h and ≥72 h; received ongoing treatment for hypoglycaemia ≥72 h; and were without congenital disorders or acute illness. Cases were compared to controls born ≥36 weeks' with brief transitional hypoglycaemia, resolving <72 h.<h4>Results</h4>39/471 infants screened met case definition: 71.8% were male, 61.5% were small-for-gestational-age (SGA), and most were admitted <6 h. Compared to controls (N = 75), key risk factors for prolonged transitional hypoglycaemia were SGA (OR = 6.4, 95%CI 2.7-15.1), severe/recurrent hypoglycaemia <24 h (OR = 16.7, 95%CI 4.5-16.1), intravenous glucose bolus <24 h (OR = 26.6, 95%CI 9.4-75.1) and maximum glucose delivery rate <48 h of ≥8 mg/kg/min (OR = 25.5, 95%CI 7.7-84.1).<h4>Conclusions</h4>Infants with prolonged transitional hypoglycaemia are predominantly male, SGA and have early severe/recurrent hypoglycaemia requiring glucose boluses and high glucose delivery rates in the first 24-48 h. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Springer Science and Business Media LLC |
|
dc.relation.ispartofseries |
Journal of perinatology : official journal of the California Perinatal Association |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Humans |
|
dc.subject |
Hypoglycemia |
|
dc.subject |
Acute Disease |
|
dc.subject |
Case-Control Studies |
|
dc.subject |
Gestational Age |
|
dc.subject |
Infant |
|
dc.subject |
Infant, Newborn |
|
dc.subject |
Infant, Small for Gestational Age |
|
dc.subject |
Male |
|
dc.subject |
Acute Disease |
|
dc.subject |
Case-Control Studies |
|
dc.subject |
Gestational Age |
|
dc.subject |
Humans |
|
dc.subject |
Hypoglycemia |
|
dc.subject |
Infant |
|
dc.subject |
Infant, Newborn |
|
dc.subject |
Infant, Small for Gestational Age |
|
dc.subject |
Male |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Obstetrics & Gynecology |
|
dc.subject |
Pediatrics |
|
dc.subject |
NEURODEVELOPMENTAL OUTCOMES |
|
dc.subject |
ALPHA-CELL |
|
dc.subject |
BETA-CELL |
|
dc.subject |
HYPERINSULINISM |
|
dc.subject |
ASSOCIATION |
|
dc.subject |
DISORDERS |
|
dc.subject |
GLYCEMIA |
|
dc.subject |
INFANTS |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
1114 Paediatrics and Reproductive Medicine |
|
dc.title |
Prolonged transitional neonatal hypoglycaemia: characterisation of a clinical syndrome. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1038/s41372-020-00891-w |
|
pubs.issue |
5 |
|
pubs.begin-page |
1149 |
|
pubs.volume |
41 |
|
dc.date.updated |
2022-01-16T21:46:23Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33279942 |
|
pubs.end-page |
1157 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.elements-id |
830934 |
|
dc.identifier.eissn |
1476-5543 |
|
dc.identifier.pii |
10.1038/s41372-020-00891-w |
|
pubs.online-publication-date |
2020-12-5 |
|