Prolonged transitional neonatal hypoglycaemia: characterisation of a clinical syndrome.

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dc.contributor.author Bailey, Miranda J
dc.contributor.author Rout, Allie
dc.contributor.author Harding, Jane E
dc.contributor.author Alsweiler, Jane M
dc.contributor.author Cutfield, Wayne S
dc.contributor.author McKinlay, Christopher JD
dc.coverage.spatial United States
dc.date.accessioned 2022-02-16T03:07:04Z
dc.date.available 2022-02-16T03:07:04Z
dc.date.issued 2021-5
dc.identifier.issn 0743-8346
dc.identifier.uri https://hdl.handle.net/2292/58197
dc.description.abstract <h4>Background</h4>We performed a case-control study to characterise infants with "prolonged transitional hypoglycaemia".<h4>Methods</h4>Cases were born ≥36 weeks' gestation; had ≥1 hypoglycaemic episode <72 h and ≥72 h; received ongoing treatment for hypoglycaemia ≥72 h; and were without congenital disorders or acute illness. Cases were compared to controls born ≥36 weeks' with brief transitional hypoglycaemia, resolving <72 h.<h4>Results</h4>39/471 infants screened met case definition: 71.8% were male, 61.5% were small-for-gestational-age (SGA), and most were admitted <6 h. Compared to controls (N = 75), key risk factors for prolonged transitional hypoglycaemia were SGA (OR = 6.4, 95%CI 2.7-15.1), severe/recurrent hypoglycaemia <24 h (OR = 16.7, 95%CI 4.5-16.1), intravenous glucose bolus <24 h (OR = 26.6, 95%CI 9.4-75.1) and maximum glucose delivery rate <48 h of ≥8 mg/kg/min (OR = 25.5, 95%CI 7.7-84.1).<h4>Conclusions</h4>Infants with prolonged transitional hypoglycaemia are predominantly male, SGA and have early severe/recurrent hypoglycaemia requiring glucose boluses and high glucose delivery rates in the first 24-48 h.
dc.format.medium Print-Electronic
dc.language eng
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartofseries Journal of perinatology : official journal of the California Perinatal Association
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.subject Humans
dc.subject Hypoglycemia
dc.subject Acute Disease
dc.subject Case-Control Studies
dc.subject Gestational Age
dc.subject Infant
dc.subject Infant, Newborn
dc.subject Infant, Small for Gestational Age
dc.subject Male
dc.subject Acute Disease
dc.subject Case-Control Studies
dc.subject Gestational Age
dc.subject Humans
dc.subject Hypoglycemia
dc.subject Infant
dc.subject Infant, Newborn
dc.subject Infant, Small for Gestational Age
dc.subject Male
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Obstetrics & Gynecology
dc.subject Pediatrics
dc.subject NEURODEVELOPMENTAL OUTCOMES
dc.subject ALPHA-CELL
dc.subject BETA-CELL
dc.subject HYPERINSULINISM
dc.subject ASSOCIATION
dc.subject DISORDERS
dc.subject GLYCEMIA
dc.subject INFANTS
dc.subject 1103 Clinical Sciences
dc.subject 1114 Paediatrics and Reproductive Medicine
dc.title Prolonged transitional neonatal hypoglycaemia: characterisation of a clinical syndrome.
dc.type Journal Article
dc.identifier.doi 10.1038/s41372-020-00891-w
pubs.issue 5
pubs.begin-page 1149
pubs.volume 41
dc.date.updated 2022-01-16T21:46:23Z
dc.rights.holder Copyright: The author en
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/33279942
pubs.end-page 1157
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Journal Article
pubs.elements-id 830934
dc.identifier.eissn 1476-5543
dc.identifier.pii 10.1038/s41372-020-00891-w
pubs.online-publication-date 2020-12-5


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