Medium Chain Triglyceride Oil: An Intended Placebo with Unexpected Adverse Effects

Show simple item record Ferguson, Lynnette R Laing, Bobbi Ellett, Stephanie Marlow, Gareth Jesuthasan, Amalini Karunasinghe, Nishi Eyres, Laurence 2022-02-16T03:25:23Z 2022-02-16T03:25:23Z 2016-1-1
dc.identifier.citation Annals of Clinical and Laboratory Research 4(3) 01 Jan 2016
dc.identifier.issn 2386-5180
dc.description.abstract Background: Medium chain triglyceride (MCT) oil is a synthetic oil made from medium chain C8 and C10 fatty acids. It has been traditionally used as a neutral “placebo” in lipid clinical trials. Thus, we had selected MCT oil capsules as a placebo, intended for comparison with an omega-3 polyunsaturated fatty acid containing supplement, to measure fatty acid profiles and inflammation in healthy people. Methods: The trial was a double-blinded, randomized, placebo controlled trial with cross-over, 4 weeks each study arm. Using serum, the fatty acids were measured and analysed by FAME analysis. HDL and LDL cholesterol profiles and C-reactive protein as a measure of inflammation were also quantified. Blood samples were collected at each time point, and participants assessed for serum lipid profiles. Results: The outcomes of interest were taken from the differences between measures for each phase of the trial. There were no significant changes in HDL or LDL cholesterol in this time, and CRP also showed no significant changes. However, levels of the fatty acids eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA) showed significant decreases after MCT supplementation. Conclusion: These results revealed an unexpectedly adverse effect of the MCT oil. Such comparisons raise questions about the use of MCT oil as a placebo, as it was not neutral in its effect on blood lipid biomarkers. The results have ramifications for claims made about the positive benefits of MCT oils.
dc.publisher Scitechnol Biosoft Pvt. Ltd.
dc.relation.ispartofseries Annals of Clinical and Laboratory Research
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.title Medium Chain Triglyceride Oil: An Intended Placebo with Unexpected Adverse Effects
dc.type Journal Article
dc.identifier.doi 10.21767/2386-5180.1000105
pubs.issue 3
pubs.volume 4 2022-01-20T02:04:41Z
dc.rights.holder Copyright: iMedPub en
pubs.publication-status Published online
dc.rights.accessrights en
pubs.subtype Article
pubs.elements-id 546216
dc.identifier.eissn 2386-5180
pubs.number 105 2016

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