dc.contributor.author |
MacDonell, Sue O |
|
dc.contributor.author |
Miller, Jody C |
|
dc.contributor.author |
Harper, Michelle J |
|
dc.contributor.author |
Reid, Malcolm R |
|
dc.contributor.author |
Haszard, Jillian J |
|
dc.contributor.author |
Gibson, Rosalind S |
|
dc.contributor.author |
Houghton, Lisa A |
|
dc.coverage.spatial |
Switzerland |
|
dc.date.accessioned |
2022-02-17T21:58:58Z |
|
dc.date.available |
2022-02-17T21:58:58Z |
|
dc.date.issued |
2021-3-25 |
|
dc.identifier.citation |
Nutrients 13(4) 25 Mar 2021 |
|
dc.identifier.issn |
2072-6643 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/58258 |
|
dc.description.abstract |
Anemia is a significant comorbidity for older adults not fully attributable to iron deficiency. Low-grade inflammation and other micronutrient deficiencies also contribute. This cross-sectional study examined the relationships between nutrient and non-nutrient factors with hemoglobin and anemia in 285 residents (>65 years) of 16 New Zealand aged-care facilities. Blood samples were analyzed for hemoglobin, ferritin, sTfR, hepcidin, zinc, selenium, and interleukin-6 (IL-6), (with ferritin, sTfR, zinc and selenium adjusted for inflammation). Linear regression models examined the relationships between micronutrient biomarkers (iron, zinc, selenium, vitamin B-12 and D), age, sex, and health factors with hemoglobin. Thirty-two percent of participants exhibited anemia, although <2% had either depleted iron stores or iron deficiency. Plasma zinc and selenium deficiencies were present in 72% and 38% of participants, respectively. Plasma zinc and total body iron (TBI) were positively associated (p < 0.05) with hemoglobin, while gastric acid suppressing medications, hepcidin, and interleukin-6 were inversely associated. These relationships were maintained after the application of anemia cut-offs. These findings emphasize the importance of considering multiple micronutrient deficiencies as risk factors for anemia. |
|
dc.language |
eng |
|
dc.publisher |
MDPI AG |
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dc.relation.ispartofseries |
Nutrients |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
anemia |
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dc.subject |
anti-secretory medications |
|
dc.subject |
inflammation |
|
dc.subject |
interleukin-6 |
|
dc.subject |
nursing home |
|
dc.subject |
proton pump inhibitors |
|
dc.subject |
soluble transferrin receptor |
|
dc.subject |
total body iron |
|
dc.subject |
Aged |
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dc.subject |
Aged, 80 and over |
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dc.subject |
Anemia |
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dc.subject |
Biomarkers |
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dc.subject |
Cross-Sectional Studies |
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dc.subject |
Female |
|
dc.subject |
Geriatric Assessment |
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dc.subject |
Homes for the Aged |
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dc.subject |
Humans |
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dc.subject |
Iron |
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dc.subject |
Male |
|
dc.subject |
Micronutrients |
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dc.subject |
New Zealand |
|
dc.subject |
Nutritional Status |
|
dc.subject |
Selenium |
|
dc.subject |
Zinc |
|
dc.subject |
0908 Food Sciences |
|
dc.subject |
1111 Nutrition and Dietetics |
|
dc.title |
Multiple Micronutrients, Including Zinc, Selenium and Iron, Are Positively Associated with Anemia in New Zealand Aged Care Residents. |
|
dc.type |
Journal Article |
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dc.identifier.doi |
10.3390/nu13041072 |
|
pubs.issue |
4 |
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pubs.begin-page |
1072 |
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pubs.volume |
13 |
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dc.date.updated |
2022-01-31T20:41:10Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33806205 |
|
pubs.publication-status |
Published online |
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dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.elements-id |
881243 |
|
dc.identifier.eissn |
2072-6643 |
|
dc.identifier.pii |
nu13041072 |
|
pubs.online-publication-date |
2021-3-25 |
|