dc.contributor.author |
Glasgow, Matthew J |
|
dc.contributor.author |
Edlin, Richard |
|
dc.contributor.author |
Harding, Jane E |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2022-02-23T22:35:08Z |
|
dc.date.available |
2022-02-23T22:35:08Z |
|
dc.date.issued |
2020-11 |
|
dc.identifier.issn |
0022-3476 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/58315 |
|
dc.description.abstract |
<h4>Objective</h4>To evaluate the long-term costs and impact on quality of life of using prophylactic dextrose gel in patients at increased risk of developing neonatal hypoglycemia.<h4>Study design</h4>A cost-utility analysis was performed from the perspective of the health system, using a decision tree to model the long-term clinical outcomes of neonatal hypoglycemia, including cerebral palsy, epilepsy, vision disturbances, and learning disabilities, in patients at increased risk of neonatal hypoglycemia who received prophylactic dextrose gel vs standard care. Model parameters including likelihoods of hypoglycemia and admission to a neonatal intensive care unit, were based on the pre-Hypoglycemia Prevention with Oral Dextrose Study. Estimations of the likelihood of long-term condition(s), and their costs, were based on review of published literature.<h4>Results</h4>Patients who received prophylactic dextrose gel incurred costs to the health system of around US $14 000 over an 18-year time horizon, accruing 11.25 quality-adjusted life-years, whereas those who did not receive prophylactic treatment incurred cost of around $16 000 and experienced a utility of 11.10 quality-adjusted life-years.<h4>Conclusions</h4>A prophylactic strategy of using dextrose gel in infants at increased risk of neonatal hypoglycemia is likely to be cost effective compared with standard care, to reduce the direct costs to the health system over an 18-year time horizon, and improve quality of life. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier BV |
|
dc.relation.ispartofseries |
The Journal of pediatrics |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Humans |
|
dc.subject |
Hypoglycemia |
|
dc.subject |
Glucose |
|
dc.subject |
Gels |
|
dc.subject |
Sweetening Agents |
|
dc.subject |
Administration, Oral |
|
dc.subject |
Risk Factors |
|
dc.subject |
Decision Trees |
|
dc.subject |
Quality-Adjusted Life Years |
|
dc.subject |
Infant, Newborn |
|
dc.subject |
Health Care Costs |
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dc.subject |
Female |
|
dc.subject |
Male |
|
dc.subject |
Administration, Oral |
|
dc.subject |
Decision Trees |
|
dc.subject |
Female |
|
dc.subject |
Gels |
|
dc.subject |
Glucose |
|
dc.subject |
Health Care Costs |
|
dc.subject |
Humans |
|
dc.subject |
Hypoglycemia |
|
dc.subject |
Infant, Newborn |
|
dc.subject |
Male |
|
dc.subject |
Quality-Adjusted Life Years |
|
dc.subject |
Risk Factors |
|
dc.subject |
Sweetening Agents |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Pediatrics |
|
dc.subject |
NEURODEVELOPMENTAL OUTCOMES |
|
dc.subject |
INTELLECTUAL DISABILITY |
|
dc.subject |
CEREBRAL-PALSY |
|
dc.subject |
TERM INFANTS |
|
dc.subject |
BRAIN-INJURY |
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dc.subject |
FOLLOW-UP |
|
dc.subject |
PRETERM |
|
dc.subject |
INFORMATION |
|
dc.subject |
PREVALENCE |
|
dc.subject |
HEALTH |
|
dc.subject |
1117 Public Health and Health Services |
|
dc.subject |
Clinical |
|
dc.subject |
Public Health |
|
dc.subject |
Neurosciences |
|
dc.subject |
Infant Mortality |
|
dc.subject |
Perinatal Period - Conditions Originating in Perinatal Period |
|
dc.subject |
Patient Safety |
|
dc.subject |
Comparative Effectiveness Research |
|
dc.subject |
Prevention |
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dc.subject |
Clinical Research |
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dc.subject |
Health Services |
|
dc.subject |
Brain Disorders |
|
dc.subject |
Cost Effectiveness Research |
|
dc.subject |
Pediatric |
|
dc.subject |
1106 Human Movement and Sports Sciences |
|
dc.subject |
1114 Paediatrics and Reproductive Medicine |
|
dc.title |
Cost-Utility Analysis of Prophylactic Dextrose Gel vs Standard Care for Neonatal Hypoglycemia in At-Risk Infants. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.jpeds.2020.06.073 |
|
pubs.begin-page |
80 |
|
pubs.volume |
226 |
|
dc.date.updated |
2022-01-16T21:50:38Z |
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dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/32634402 |
|
pubs.end-page |
86.e1 |
|
pubs.publication-status |
Published |
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dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
805504 |
|
dc.identifier.eissn |
1097-6833 |
|
dc.identifier.pii |
S0022-3476(20)30827-1 |
|
pubs.online-publication-date |
2020-7-4 |
|