dc.contributor.author |
Marasini, Sanjay |
|
dc.contributor.author |
Leanse, Leon G |
|
dc.contributor.author |
Dai, Tianhong |
|
dc.coverage.spatial |
Netherlands |
|
dc.date.accessioned |
2022-03-03T01:33:19Z |
|
dc.date.available |
2022-03-03T01:33:19Z |
|
dc.date.issued |
2021-8 |
|
dc.identifier.issn |
0169-409X |
|
dc.identifier.uri |
https://hdl.handle.net/2292/58385 |
|
dc.description.abstract |
Recently, there have been increasing numbers of publications illustrating the potential of light-based antimicrobial therapies to combat antimicrobial resistance. Several modalities, in particular, which have proven antimicrobial efficacy against a wide range of pathogenic microbes include: photodynamic therapy (PDT), ultraviolet light (UVA, UVB and UVC), and antimicrobial blue light (aBL). Using these techniques, microbial cells can be inactivated rapidly, either by inducing reactive oxygen species that are deleterious to the microbial cells (PDT, aBL and UVA) or by causing irreversible DNA damage via direct absorption (UVB and UVC). Given the multi-targeted nature of light-based antimicrobial modalities, it has been hypothesised that resistance development to these approaches is highly unlikely. Furthermore, with the exception of a small number of studies, it has been found that resistance to light based anti-infective agents appears unlikely, irrespective of the modality in question. The concurrent literature however stipulates, that further studies should incorporate standardised microbial tolerance assessments for light-based therapies to better assess the reproducibility of these observations. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier BV |
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dc.relation.ispartofseries |
Advanced drug delivery reviews |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
Humans |
|
dc.subject |
Bacterial Infections |
|
dc.subject |
Photosensitizing Agents |
|
dc.subject |
Anti-Bacterial Agents |
|
dc.subject |
Photochemotherapy |
|
dc.subject |
Drug Resistance, Bacterial |
|
dc.subject |
Antimicrobial blue light |
|
dc.subject |
Antimicrobial resistance |
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dc.subject |
Bacterial tolerance |
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dc.subject |
Light resistance |
|
dc.subject |
Photodynamic therapy |
|
dc.subject |
Ultraviolet light |
|
dc.subject |
Anti-Bacterial Agents |
|
dc.subject |
Bacterial Infections |
|
dc.subject |
Drug Resistance, Bacterial |
|
dc.subject |
Humans |
|
dc.subject |
Photochemotherapy |
|
dc.subject |
Photosensitizing Agents |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Pharmacology & Pharmacy |
|
dc.subject |
Antimicrobial blue light |
|
dc.subject |
Antimicrobial resistance |
|
dc.subject |
Bacterial tolerance |
|
dc.subject |
Light resistance |
|
dc.subject |
Photodynamic therapy |
|
dc.subject |
Ultraviolet light |
|
dc.subject |
ANTIMICROBIAL PHOTODYNAMIC THERAPY |
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dc.subject |
ULTRAVIOLET-C IRRADIATION |
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dc.subject |
IN-VITRO |
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dc.subject |
HIGH-ALTITUDE |
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dc.subject |
UV-B |
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dc.subject |
STAPHYLOCOCCUS-AUREUS |
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dc.subject |
ESCHERICHIA-COLI |
|
dc.subject |
CELLULAR TARGETS |
|
dc.subject |
PRESSURE ULCERS |
|
dc.subject |
CROSS-LINKING |
|
dc.subject |
1115 Pharmacology and Pharmaceutical Sciences |
|
dc.title |
Can microorganisms develop resistance against light based anti-infective agents? |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.addr.2021.05.032 |
|
pubs.begin-page |
113822 |
|
pubs.volume |
175 |
|
dc.date.updated |
2022-02-07T23:12:03Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/34089778 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Review |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
855463 |
|
dc.identifier.eissn |
1872-8294 |
|
dc.identifier.pii |
S0169-409X(21)00196-4 |
|
pubs.number |
113822 |
|