dc.contributor.author |
Arachchige, GRP |
|
dc.contributor.author |
Thorstensen, EB |
|
dc.contributor.author |
Coe, M |
|
dc.contributor.author |
McKenzie, EJ |
|
dc.contributor.author |
O'Sullivan, JM |
|
dc.contributor.author |
Pook, CJ |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2022-03-03T01:37:34Z |
|
dc.date.available |
2022-03-03T01:37:34Z |
|
dc.date.issued |
2021-1 |
|
dc.identifier.citation |
Analytical biochemistry 613:113980 Jan 2021 |
|
dc.identifier.issn |
0003-2697 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/58388 |
|
dc.description.abstract |
Fat soluble vitamers (FSV) are several biochemically diverse micronutrients essential for healthy development, growth, metabolism, and cell regulation. We cannot synthesize FSV completely or at the required concentrations. Deficiency or excess of FSV can result in many health problems. Plasma is the most accessible sample matrix for the quantification of FSV. However, due to its complexity and other analytical challenges (e.g., FSV sensitivity to light, oxygen, heat, pH, chemical heterogeneity, standard availability), developing a method for the simultaneous quantification of multiple FSV at physiological concentrations has been challenging. In this systematic review, we examine the parameters and criteria used in existing Liquid Chromatography with tandem Mass Spectrometry (LC-MS/MS) methods for FSV quantification to the extraction method, chromatographic resolution, matrix effects, and method validation as critical to a sensitive and robust method. We conclude that the final FSV method sensitivity is predominantly based on aforementioned criteria and future method development using LC-MS/MS will benefit from the application of this systematic review. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier BV |
|
dc.relation.ispartofseries |
Analytical biochemistry |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Animals |
|
dc.subject |
Humans |
|
dc.subject |
Vitamins |
|
dc.subject |
Chemical Fractionation |
|
dc.subject |
Chromatography, High Pressure Liquid |
|
dc.subject |
Solubility |
|
dc.subject |
Tandem Mass Spectrometry |
|
dc.subject |
Hydrophobic and Hydrophilic Interactions |
|
dc.subject |
Fat-soluble vitamers (FSV) |
|
dc.subject |
Limit of quantitation (LOQ) |
|
dc.subject |
Tandem mass spectrometry (MS/MS) |
|
dc.subject |
Ultrahigh pressure chromatography (UPLC) |
|
dc.subject |
Animals |
|
dc.subject |
Chemical Fractionation |
|
dc.subject |
Chromatography, High Pressure Liquid |
|
dc.subject |
Humans |
|
dc.subject |
Hydrophobic and Hydrophilic Interactions |
|
dc.subject |
Solubility |
|
dc.subject |
Tandem Mass Spectrometry |
|
dc.subject |
Vitamins |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Physical Sciences |
|
dc.subject |
Biochemical Research Methods |
|
dc.subject |
Biochemistry & Molecular Biology |
|
dc.subject |
Chemistry, Analytical |
|
dc.subject |
Chemistry |
|
dc.subject |
Fat-soluble vitamers (FSV) |
|
dc.subject |
Ultrahigh pressure chromatography (UPLC) |
|
dc.subject |
Tandem mass spectrometry (MS/MS) |
|
dc.subject |
Limit of quantitation (LOQ) |
|
dc.subject |
TANDEM MASS-SPECTROMETRY |
|
dc.subject |
PRESSURE CHEMICAL-IONIZATION |
|
dc.subject |
HIGH-THROUGHPUT METHOD |
|
dc.subject |
ALPHA-TOCOPHEROL |
|
dc.subject |
HUMAN SERUM |
|
dc.subject |
GRADIENT ELUTION |
|
dc.subject |
ELECTROSPRAY-IONIZATION |
|
dc.subject |
HUMAN PLASMA |
|
dc.subject |
CHROMATOGRAPHY |
|
dc.subject |
VITAMINS |
|
dc.subject |
0301 Analytical Chemistry |
|
dc.subject |
0399 Other Chemical Sciences |
|
dc.subject |
0601 Biochemistry and Cell Biology |
|
dc.title |
LC-MS/MS quantification of fat soluble vitamers - A systematic review. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.ab.2020.113980 |
|
pubs.begin-page |
113980 |
|
pubs.volume |
613 |
|
dc.date.updated |
2022-02-16T12:05:50Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33065116 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Systematic Review |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
831975 |
|
dc.identifier.eissn |
1096-0309 |
|
dc.identifier.pii |
S0003-2697(20)30512-1 |
|
pubs.number |
113980 |
|