dc.contributor.author |
Peng, Yaoyao |
|
dc.contributor.author |
Bishop, Karen Suzanne |
|
dc.contributor.author |
Ferguson, Lynnette Robin |
|
dc.contributor.author |
Quek, Siew Young |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2022-03-03T02:05:49Z |
|
dc.date.available |
2022-03-03T02:05:49Z |
|
dc.date.issued |
2022-1-31 |
|
dc.identifier.issn |
0308-8146 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/58396 |
|
dc.description.abstract |
This study aimed to explore the potential anticancer activity of phenolic-rich feijoa extracts from the flesh, peel, and whole fruit on the human prostate cancer cell line (LNCaP). Results showed that feijoa extracts had cancer-specific anti-proliferative activity on the LNCaP cell line. The anticancer activity of feijoa extracts was shown through activation of the caspase-dependent apoptosis pathway based on the increase of sub-G1 phase in the cell cycle, the decrease of mitochondrial membrane potential, as well as the elevated caspase 3, 8, and 9 activity in the treated LNCaP cells. The anti-cancer activity of feijoa extracts could be attributed to the high total phenolic contents (0.14-0.37 mg GAE/mg dw) and, in particular, the high ellagic acid content (2.662-9.119 μg/mg dw). The successful activation of the caspase-dependent apoptosis pathway indicates that phenolic-rich feijoa extracts have a good potential to be utilized as a functional ingredient in foods and nutraceuticals. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier BV |
|
dc.relation.ispartofseries |
Food chemistry |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Apoptosis pathway |
|
dc.subject |
Caspase activation |
|
dc.subject |
Feijoa extract |
|
dc.subject |
LC-ESI-MS |
|
dc.subject |
Phenolic profiling |
|
dc.subject |
Prostate cancer |
|
dc.title |
Phenolic-rich feijoa extracts from flesh, peel and whole fruit activate apoptosis pathways in the LNCaP cell line. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.foodchem.2022.132285 |
|
pubs.begin-page |
132285 |
|
pubs.volume |
383 |
|
dc.date.updated |
2022-02-18T18:44:49Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/35168051 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.elements-id |
883330 |
|
dc.identifier.eissn |
1873-7072 |
|
dc.identifier.pii |
S0308-8146(22)00246-1 |
|
pubs.number |
132285 |
|