The impact of antenatal Bisphenol A exposure on male reproductive function at 20-22 years of age.

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dc.contributor.author Hart, Roger J
dc.contributor.author Doherty, Dorota A
dc.contributor.author Keelan, Jeffrey A
dc.contributor.author Minaee, Novia S
dc.contributor.author Thorstensen, Eric B
dc.contributor.author Dickinson, Jan E
dc.contributor.author Pennell, Craig E
dc.contributor.author Newnham, John P
dc.contributor.author McLachlan, Robert
dc.contributor.author Norman, Robert J
dc.contributor.author Handelsman, David J
dc.coverage.spatial Netherlands
dc.date.accessioned 2022-03-03T02:54:18Z
dc.date.available 2022-03-03T02:54:18Z
dc.date.issued 2018-3
dc.identifier.issn 1472-6483
dc.identifier.uri https://hdl.handle.net/2292/58416
dc.description.abstract Bisphenol A (BPA) is a ubiquitous chemical suspected to possess oestrogenic hormonal activities. Male population studies suggest a negative impact on testicular function. As Sertoli cell proliferation occurs during fetal or early postnatal life, it is speculated that oestrogenic environmental exposures may influence mature testicular function. Among 705 Western Australian Pregnancy Cohort (Raine) Study men aged 20-22 years, 404 underwent testicular ultrasound examination (149 had maternal serum available), and/or 365 provided semen (136 had maternal serum) and/or 609 serum samples for sex steroids, gonadotrophins and inhibin B analysis (244 had maternal serum). Maternal serum collected at 18 and 34 weeks' gestation was pooled and assayed for concentrations of total BPA (free plus conjugated) as an estimate of antenatal exposure. Testicular volume was calculated by ultrasonography, and semen analysis performed. Serum LH, FSH and inhibin B were measured by immunoassay; testosterone, oestradiol, oestrone andBPA were measured by liquid chromatography-mass spectrometry. BPA levels were detectable in most (89%) maternal serum samples. After adjustment for maternal smoking, abstinence and varicocele, sperm concentration and motility were significantly correlated to maternal serum BPA (r = 0.18; P = 0.04 for both). No other associations of maternal serum BPA with testicular function were observed.
dc.format.medium Print-Electronic
dc.language eng
dc.publisher Elsevier BV
dc.relation.ispartofseries Reproductive biomedicine online
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.subject Testis
dc.subject Humans
dc.subject Prenatal Exposure Delayed Effects
dc.subject Benzhydryl Compounds
dc.subject Phenols
dc.subject Gonadal Steroid Hormones
dc.subject Free Radical Scavengers
dc.subject Cohort Studies
dc.subject Maternal Exposure
dc.subject Sperm Motility
dc.subject Fertility
dc.subject Pregnancy
dc.subject Adult
dc.subject Female
dc.subject Male
dc.subject Semen Analysis
dc.subject Young Adult
dc.subject Bisphenol A (BPA)
dc.subject Endocrine disrupter
dc.subject Raine Study
dc.subject Reproductive hormones
dc.subject Semen
dc.subject Testicle
dc.subject Adult
dc.subject Benzhydryl Compounds
dc.subject Cohort Studies
dc.subject Female
dc.subject Fertility
dc.subject Free Radical Scavengers
dc.subject Gonadal Steroid Hormones
dc.subject Humans
dc.subject Male
dc.subject Maternal Exposure
dc.subject Phenols
dc.subject Pregnancy
dc.subject Prenatal Exposure Delayed Effects
dc.subject Semen Analysis
dc.subject Sperm Motility
dc.subject Testis
dc.subject Young Adult
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Obstetrics & Gynecology
dc.subject Reproductive Biology
dc.subject Bisphenol A (BPA)
dc.subject Endocrine disrupter
dc.subject Raine Study
dc.subject Reproductive hormones
dc.subject Semen
dc.subject Testicle
dc.subject TESTICULAR DYSGENESIS SYNDROME
dc.subject ENVIRONMENTAL ESTROGENS
dc.subject SPERM COUNTS
dc.subject HEALTH
dc.subject SERUM
dc.subject SEMEN
dc.subject ANDROGENS
dc.subject PREGNANCY
dc.subject ANIMALS
dc.subject TRENDS
dc.subject 1114 Paediatrics and Reproductive Medicine
dc.subject Contraception/Reproduction
dc.subject Urologic Diseases
dc.subject Reproductive Health and Childbirth
dc.subject 1114 Paediatrics and Reproductive Medicine
dc.title The impact of antenatal Bisphenol A exposure on male reproductive function at 20-22 years of age.
dc.type Journal Article
dc.identifier.doi 10.1016/j.rbmo.2017.11.009
pubs.issue 3
pubs.begin-page 340
pubs.volume 36
dc.date.updated 2022-02-28T00:52:34Z
dc.rights.holder Copyright: The author en
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/29291929
pubs.end-page 347
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/RetrictedAccess en
pubs.subtype Journal Article
pubs.elements-id 720751
dc.identifier.eissn 1472-6491
dc.identifier.pii S1472-6483(17)30671-5


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