dc.contributor.author |
Quilez, Ester |
|
dc.contributor.author |
Burchell, Richard K |
|
dc.contributor.author |
Thorstensen, Eric B |
|
dc.contributor.author |
Weidgraaf, Karin |
|
dc.contributor.author |
Parbhu, Stacey E |
|
dc.contributor.author |
Lopez-Villalobos, Nicolas |
|
dc.contributor.author |
Gal, Arnon |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2022-03-07T01:25:49Z |
|
dc.date.available |
2022-03-07T01:25:49Z |
|
dc.date.issued |
2020-3 |
|
dc.identifier.issn |
1040-6387 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/58491 |
|
dc.description.abstract |
Nonadrenal diseases (NAD), including congestive heart failure (CHF), can affect the conversion of cortisone to cortisol favoring the production of cortisol's urinary downstream metabolites 5α/5β-tetrahydrocortisol (THF) relative to tetrahydrocortisone (THE). We hypothesized that healthy dogs would have lower urinary levels of cortisol, cortisone, THF, and THE than dogs with hypercortisolism (HC) or CHF, and the latter would have higher urinary levels of THF and lower THE than dogs with HC. Four, 9, and 8 dogs with HC, CHF, and normal health, respectively, were included in a pilot prospective cross-sectional study. A single morning voided urine sample was analyzed for urinary cortisol metabolites by liquid chromatography-mass spectrometry. The percentages of conjugated urinary metabolites were significantly higher in dogs with CHF than in healthy dogs (<i>p</i> = 0.001), and not different in HC dogs (<i>p</i> = 0.07). Log-transformed urine cortisol metabolites-to-creatinine ratios in healthy dogs were significantly lower than the 2 other groups (<i>p</i> < 0.001). The urinary free THE:THF ratio was significantly higher (<i>p</i> < 0.001) than the urinary total and conjugated THE:THF ratios. Health status did not affect the total, conjugated, and free THE:THF ratios (<i>p</i> = 0.61). Additional studies are needed to investigate differences in cortisol metabolites between dogs with HC and NAD to accurately discriminate between the groups. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
SAGE Publications |
|
dc.relation.ispartofseries |
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Animals |
|
dc.subject |
Dogs |
|
dc.subject |
Cushing Syndrome |
|
dc.subject |
Dog Diseases |
|
dc.subject |
Hydrocortisone |
|
dc.subject |
Prospective Studies |
|
dc.subject |
Cross-Sectional Studies |
|
dc.subject |
Pilot Projects |
|
dc.subject |
Reference Values |
|
dc.subject |
Heart Failure |
|
dc.subject |
11β-hydroxysteroid dehydrogenase 1 |
|
dc.subject |
5α/5β-tetrahydrocortisol |
|
dc.subject |
Cushing disease |
|
dc.subject |
canine |
|
dc.subject |
dogs |
|
dc.subject |
liquid chromatography–mass spectrometry |
|
dc.subject |
tetrahydrocortisone |
|
dc.subject |
Animals |
|
dc.subject |
Cross-Sectional Studies |
|
dc.subject |
Cushing Syndrome |
|
dc.subject |
Dog Diseases |
|
dc.subject |
Dogs |
|
dc.subject |
Heart Failure |
|
dc.subject |
Hydrocortisone |
|
dc.subject |
Pilot Projects |
|
dc.subject |
Prospective Studies |
|
dc.subject |
Reference Values |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Veterinary Sciences |
|
dc.subject |
11 beta-hydroxysteroid dehydrogenase 1 |
|
dc.subject |
5 alpha |
|
dc.subject |
5 beta-tetrahydrocortisol |
|
dc.subject |
canine |
|
dc.subject |
Cushing disease |
|
dc.subject |
dogs |
|
dc.subject |
liquid chromatography-mass spectrometry |
|
dc.subject |
tetrahydrocortisone |
|
dc.subject |
CREATININE RATIO |
|
dc.subject |
CANINE |
|
dc.subject |
DIAGNOSIS |
|
dc.subject |
HYPERADRENOCORTICISM |
|
dc.subject |
TESTS |
|
dc.subject |
1117 Public Health and Health Services |
|
dc.subject |
Cardiovascular |
|
dc.subject |
Heart Disease |
|
dc.subject |
Cardiovascular |
|
dc.subject |
0608 Zoology |
|
dc.subject |
0707 Veterinary Sciences |
|
dc.title |
Cortisol urinary metabolites in dogs with hypercortisolism, congestive heart failure, and healthy dogs: pilot investigation. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1177/1040638719899645 |
|
pubs.issue |
2 |
|
pubs.begin-page |
317 |
|
pubs.volume |
32 |
|
dc.date.updated |
2022-02-28T00:49:19Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/31924129 |
|
pubs.end-page |
323 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
792965 |
|
dc.identifier.eissn |
1943-4936 |
|
pubs.number |
ARTN 1040638719899645 |
|
pubs.online-publication-date |
2020-1-10 |
|