Cortisol urinary metabolites in dogs with hypercortisolism, congestive heart failure, and healthy dogs: pilot investigation.

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dc.contributor.author Quilez, Ester
dc.contributor.author Burchell, Richard K
dc.contributor.author Thorstensen, Eric B
dc.contributor.author Weidgraaf, Karin
dc.contributor.author Parbhu, Stacey E
dc.contributor.author Lopez-Villalobos, Nicolas
dc.contributor.author Gal, Arnon
dc.coverage.spatial United States
dc.date.accessioned 2022-03-07T01:25:49Z
dc.date.available 2022-03-07T01:25:49Z
dc.date.issued 2020-3
dc.identifier.issn 1040-6387
dc.identifier.uri https://hdl.handle.net/2292/58491
dc.description.abstract Nonadrenal diseases (NAD), including congestive heart failure (CHF), can affect the conversion of cortisone to cortisol favoring the production of cortisol's urinary downstream metabolites 5α/5β-tetrahydrocortisol (THF) relative to tetrahydrocortisone (THE). We hypothesized that healthy dogs would have lower urinary levels of cortisol, cortisone, THF, and THE than dogs with hypercortisolism (HC) or CHF, and the latter would have higher urinary levels of THF and lower THE than dogs with HC. Four, 9, and 8 dogs with HC, CHF, and normal health, respectively, were included in a pilot prospective cross-sectional study. A single morning voided urine sample was analyzed for urinary cortisol metabolites by liquid chromatography-mass spectrometry. The percentages of conjugated urinary metabolites were significantly higher in dogs with CHF than in healthy dogs (<i>p</i> = 0.001), and not different in HC dogs (<i>p</i> = 0.07). Log-transformed urine cortisol metabolites-to-creatinine ratios in healthy dogs were significantly lower than the 2 other groups (<i>p</i> < 0.001). The urinary free THE:THF ratio was significantly higher (<i>p</i> < 0.001) than the urinary total and conjugated THE:THF ratios. Health status did not affect the total, conjugated, and free THE:THF ratios (<i>p</i> = 0.61). Additional studies are needed to investigate differences in cortisol metabolites between dogs with HC and NAD to accurately discriminate between the groups.
dc.format.medium Print-Electronic
dc.language eng
dc.publisher SAGE Publications
dc.relation.ispartofseries Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.subject Animals
dc.subject Dogs
dc.subject Cushing Syndrome
dc.subject Dog Diseases
dc.subject Hydrocortisone
dc.subject Prospective Studies
dc.subject Cross-Sectional Studies
dc.subject Pilot Projects
dc.subject Reference Values
dc.subject Heart Failure
dc.subject 11β-hydroxysteroid dehydrogenase 1
dc.subject 5α/5β-tetrahydrocortisol
dc.subject Cushing disease
dc.subject canine
dc.subject dogs
dc.subject liquid chromatography–mass spectrometry
dc.subject tetrahydrocortisone
dc.subject Animals
dc.subject Cross-Sectional Studies
dc.subject Cushing Syndrome
dc.subject Dog Diseases
dc.subject Dogs
dc.subject Heart Failure
dc.subject Hydrocortisone
dc.subject Pilot Projects
dc.subject Prospective Studies
dc.subject Reference Values
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Veterinary Sciences
dc.subject 11 beta-hydroxysteroid dehydrogenase 1
dc.subject 5 alpha
dc.subject 5 beta-tetrahydrocortisol
dc.subject canine
dc.subject Cushing disease
dc.subject dogs
dc.subject liquid chromatography-mass spectrometry
dc.subject tetrahydrocortisone
dc.subject CREATININE RATIO
dc.subject CANINE
dc.subject DIAGNOSIS
dc.subject HYPERADRENOCORTICISM
dc.subject TESTS
dc.subject 1117 Public Health and Health Services
dc.subject Cardiovascular
dc.subject Heart Disease
dc.subject Cardiovascular
dc.subject 0608 Zoology
dc.subject 0707 Veterinary Sciences
dc.title Cortisol urinary metabolites in dogs with hypercortisolism, congestive heart failure, and healthy dogs: pilot investigation.
dc.type Journal Article
dc.identifier.doi 10.1177/1040638719899645
pubs.issue 2
pubs.begin-page 317
pubs.volume 32
dc.date.updated 2022-02-28T00:49:19Z
dc.rights.holder Copyright: The author en
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/31924129
pubs.end-page 323
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/RetrictedAccess en
pubs.subtype research-article
pubs.subtype Journal Article
pubs.elements-id 792965
dc.identifier.eissn 1943-4936
pubs.number ARTN 1040638719899645
pubs.online-publication-date 2020-1-10


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