dc.contributor.author |
Hajishafiee, Maryam |
|
dc.contributor.author |
Elovaris, Rachel A |
|
dc.contributor.author |
Jones, Karen L |
|
dc.contributor.author |
Heilbronn, Leonie K |
|
dc.contributor.author |
Horowitz, Michael |
|
dc.contributor.author |
Poppitt, Sally D |
|
dc.contributor.author |
Feinle-Bisset, Christine |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2022-04-14T03:44:52Z |
|
dc.date.available |
2022-04-14T03:44:52Z |
|
dc.date.issued |
2021-1-5 |
|
dc.identifier.citation |
Nutrition & diabetes 11(1):3 05 Jan 2021 |
|
dc.identifier.issn |
2044-4052 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/58725 |
|
dc.description.abstract |
<h4>Background</h4>The rate of gastric emptying and glucoregulatory hormones are key determinants of postprandial glycaemia. Intragastric administration of L-tryptophan slows gastric emptying and reduces the glycaemic response to a nutrient drink in lean individuals and those with obesity. We investigated whether tryptophan decreases postprandial glycaemia and slows gastric emptying in type 2 diabetes (T2D).<h4>Methods</h4>Twelve men with T2D (age: 63 ± 2 years, HbA1c: 49.7 ± 2.5 mmol/mol, BMI: 30 ± 1 kg/m<sup>2</sup>) received, on three separate occasions, 3 g ('Trp-3') or 1.5 g ('Trp-1.5') tryptophan, or control (0.9% saline), intragastrically, in randomised, double-blind fashion, 30 min before a mixed-nutrient drink (500 kcal, 74 g carbohydrates), containing 3 g 3-O-methyl-D-glucose (3-OMG) to assess glucose absorption. Venous blood samples were obtained at baseline, after tryptophan, and for 2 h post-drink for measurements of plasma glucose, C-peptide, glucagon and 3-OMG. Gastric emptying of the drink was quantified using two-dimensional ultrasound.<h4>Results</h4>Tryptophan alone stimulated C-peptide (P = 0.002) and glucagon (P = 0.04), but did not affect fasting glucose. In response to the drink, Trp-3 lowered plasma glucose from t = 15-30 min and from t = 30-45 min compared with control and Trp-1.5, respectively (both P < 0.05), with no differences in peak glucose between treatments. Gastric emptying tended to be slower after Trp-3, but not Trp-1.5, than control (P = 0.06). Plasma C-peptide, glucagon and 3-OMG increased on all days, with no major differences between treatments.<h4>Conclusions</h4>In people with T2D, intragastric administration of 3 g tryptophan modestly slows gastric emptying, associated with a delayed rise, but not an overall lowering of, postprandial glucose. |
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dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
Springer Science and Business Media LLC |
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dc.relation.ispartofseries |
Nutrition & diabetes |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Humans |
|
dc.subject |
Diabetes Mellitus, Type 2 |
|
dc.subject |
Obesity |
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dc.subject |
Glucagon |
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dc.subject |
Insulin |
|
dc.subject |
C-Peptide |
|
dc.subject |
3-O-Methylglucose |
|
dc.subject |
Glucose |
|
dc.subject |
Blood Glucose |
|
dc.subject |
Tryptophan |
|
dc.subject |
Drug Administration Routes |
|
dc.subject |
Double-Blind Method |
|
dc.subject |
Gastric Emptying |
|
dc.subject |
Intestinal Absorption |
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dc.subject |
Postprandial Period |
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dc.subject |
Beverages |
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dc.subject |
Aged |
|
dc.subject |
Middle Aged |
|
dc.subject |
Male |
|
dc.subject |
Nutrients |
|
dc.subject |
3-O-Methylglucose |
|
dc.subject |
Aged |
|
dc.subject |
Beverages |
|
dc.subject |
Blood Glucose |
|
dc.subject |
C-Peptide |
|
dc.subject |
Diabetes Mellitus, Type 2 |
|
dc.subject |
Double-Blind Method |
|
dc.subject |
Drug Administration Routes |
|
dc.subject |
Gastric Emptying |
|
dc.subject |
Glucagon |
|
dc.subject |
Glucose |
|
dc.subject |
Humans |
|
dc.subject |
Insulin |
|
dc.subject |
Intestinal Absorption |
|
dc.subject |
Male |
|
dc.subject |
Middle Aged |
|
dc.subject |
Nutrients |
|
dc.subject |
Obesity |
|
dc.subject |
Postprandial Period |
|
dc.subject |
Tryptophan |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Endocrinology & Metabolism |
|
dc.subject |
Nutrition & Dietetics |
|
dc.subject |
PEPTIDE-1 7-36 AMIDE |
|
dc.subject |
AMINO-ACIDS |
|
dc.subject |
BLOOD-GLUCOSE |
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dc.subject |
ENERGY-INTAKE |
|
dc.subject |
INSULIN-SECRETION |
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dc.subject |
ANTRAL AREA |
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dc.subject |
FOOD-INTAKE |
|
dc.subject |
HEALTHY |
|
dc.subject |
PROTEIN |
|
dc.subject |
APPETITE |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
1111 Nutrition and Dietetics |
|
dc.subject |
1601 Anthropology |
|
dc.title |
Effects of intragastric administration of L-tryptophan on the glycaemic response to a nutrient drink in men with type 2 diabetes - impacts on gastric emptying, glucoregulatory hormones and glucose absorption. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1038/s41387-020-00146-9 |
|
pubs.issue |
1 |
|
pubs.begin-page |
3 |
|
pubs.volume |
11 |
|
dc.date.updated |
2022-03-15T17:15:36Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/33414406 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
research-article |
|
pubs.subtype |
Randomized Controlled Trial |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
834331 |
|
dc.identifier.eissn |
2044-4052 |
|
dc.identifier.pii |
10.1038/s41387-020-00146-9 |
|
pubs.number |
3 |
|
pubs.online-publication-date |
2021-1-5 |
|