dc.contributor.author | Hajishafiee, Maryam | |
dc.contributor.author | Ullrich, Sina S | |
dc.contributor.author | Fitzgerald, Penelope Ce | |
dc.contributor.author | Horowitz, Michael | |
dc.contributor.author | Lange, Kylie | |
dc.contributor.author | Poppitt, Sally D | |
dc.contributor.author | Feinle-Bisset, Christine | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2022-04-19T23:09:28Z | |
dc.date.available | 2022-04-19T23:09:28Z | |
dc.date.issued | 2021-10 | |
dc.identifier.issn | 0022-3166 | |
dc.identifier.uri | https://hdl.handle.net/2292/58740 | |
dc.description.abstract | <h4>Background</h4>l-Tryptophan reduces energy intake in healthy men. The underlying mechanisms, including appetite, plasma cholecystokinin (CCK), tryptophan (Trp), and the ratio of Trp to large neutral amino acids (Trp:LNAAs ratio), and whether responses differ in lean and obese individuals, are uncertain.<h4>Objectives</h4>We evaluated the effects of intragastric Trp on energy intake (primary outcome) and their potential mechanisms, pre- and postmeal, in lean men and those with obesity.<h4>Methods</h4>Twelve lean men [mean ± SD age: 30 ± 3 y; BMI (in kg/m2): 23 ± 1] and 13 men with obesity (mean ± SD age: 31 ± 3 y; BMI: 33 ± 1) received, on 3 separate occasions, in double-blind, randomized order, 3 g ("Trp-3") or 1.5 g ("Trp-1.5") Trp, or control ("C"), intragastrically, 30 min before a buffet-meal. Energy intake from the buffet-meal, hunger, fullness, and plasma CCK and amino acid concentrations were measured in response to Trp alone and for 2 h postmeal. Data were analyzed using maximum likelihood mixed-effects models, with treatment, group, and treatment-by-group interaction as fixed effects.<h4>Results</h4>Trp alone increased plasma CCK, Trp, and the Trp:LNAAs ratio (all P < 0.001), with no difference between groups. Trp suppressed energy intake (P < 0.001), with no difference between groups (lean, C: 1085 ± 102 kcal, Trp-1.5: 1009 ± 92 kcal, Trp-3: 868 ± 104 kcal; obese, C: 1249 ± 98 kcal, Trp-1.5: 1217 ± 90 kcal, Trp-3: 1012 ± 100 kcal). Postmeal, fullness was greater after Trp-3 than after C and Trp-1.5 (all P < 0.05), and in men with obesity than in lean men (P < 0.05). Plasma Trp and the Trp:LNAAs ratio were greater after Trp-3 and Trp-1.5 than after C (all P < 0.001), and tended to be less in men with obesity than in the lean (P = 0.07) (Trp:LNAAs ratio: lean, C: 1.5 ± 0.2, Trp-1.5: 6.9 ± 0.7, Trp-3: 10.7 ± 1.4; obese, C: 1.4 ± 0.1, Trp-1.5: 4.6 ± 0.7, Trp-3: 7.8 ± 1.3). There were inverse correlations of energy intake with plasma Trp and the Trp:LNAAs ratio in both groups (lean, both r = -0.50, P < 0.01; obese, both r = -0.40, P < 0.05).<h4>Conclusions</h4>Intragastric Trp has potent energy intake-suppressant effects, in both lean men and those with obesity, apparently related to the Trp:LNAAs ratio. | |
dc.format.medium | ||
dc.language | eng | |
dc.publisher | Oxford University Press (OUP) | |
dc.relation.ispartofseries | The Journal of nutrition | |
dc.rights | Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. | |
dc.rights.uri | https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm | |
dc.subject | Humans | |
dc.subject | Obesity | |
dc.subject | Cholecystokinin | |
dc.subject | Tryptophan | |
dc.subject | Double-Blind Method | |
dc.subject | Appetite | |
dc.subject | Energy Intake | |
dc.subject | Adult | |
dc.subject | Male | |
dc.subject | amino acids | |
dc.subject | food intake | |
dc.subject | fullness | |
dc.subject | hunger | |
dc.subject | obesity | |
dc.subject | tryptophan to large neutral amino acids ratio | |
dc.subject | Adult | |
dc.subject | Appetite | |
dc.subject | Cholecystokinin | |
dc.subject | Double-Blind Method | |
dc.subject | Energy Intake | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Obesity | |
dc.subject | Tryptophan | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Nutrition & Dietetics | |
dc.subject | amino acids | |
dc.subject | food intake | |
dc.subject | obesity | |
dc.subject | tryptophan to large neutral amino acids ratio | |
dc.subject | hunger | |
dc.subject | fullness | |
dc.subject | NEUTRAL AMINO-ACID | |
dc.subject | FOOD-INTAKE | |
dc.subject | CALORIE INTAKE | |
dc.subject | HIGH-PROTEIN | |
dc.subject | SEROTONIN | |
dc.subject | CARBOHYDRATE | |
dc.subject | INSULIN | |
dc.subject | WEIGHT | |
dc.subject | HUNGER | |
dc.subject | GLYCEMIA | |
dc.subject | 0702 Animal Production | |
dc.subject | 0908 Food Sciences | |
dc.subject | 1111 Nutrition and Dietetics | |
dc.title | Suppression of Energy Intake by Intragastric l-Tryptophan in Lean and Obese Men: Relations with Appetite Perceptions and Circulating Cholecystokinin and Tryptophan. | |
dc.type | Journal Article | |
dc.identifier.doi | 10.1093/jn/nxab218 | |
pubs.issue | 10 | |
pubs.begin-page | 2932 | |
pubs.volume | 151 | |
dc.date.updated | 2022-03-15T16:41:09Z | |
dc.rights.holder | Copyright: The author | en |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/34255069 | |
pubs.end-page | 2941 | |
pubs.publication-status | Published | |
dc.rights.accessrights | http://purl.org/eprint/accessRights/RestrictedAccess | en |
pubs.subtype | Research Support, Non-U.S. Gov't | |
pubs.subtype | Randomized Controlled Trial | |
pubs.subtype | Journal Article | |
pubs.elements-id | 860270 | |
dc.identifier.eissn | 1541-6100 | |
dc.identifier.pii | 6320061 | |
pubs.online-publication-date | 2021-7-13 |