dc.contributor.author |
Navas-Carretero, Santiago |
|
dc.contributor.author |
San-Cristobal, Rodrigo |
|
dc.contributor.author |
Siig Vestentoft, Pia |
|
dc.contributor.author |
Brand-Miller, Jennie C |
|
dc.contributor.author |
Jalo, Elli |
|
dc.contributor.author |
Westerterp-Plantenga, Margriet |
|
dc.contributor.author |
Simpson, Elizabeth J |
|
dc.contributor.author |
Handjieva-Darlenska, Teodora |
|
dc.contributor.author |
Stratton, Gareth |
|
dc.contributor.author |
Huttunen-Lenz, Maija |
|
dc.contributor.author |
Lam, Tony |
|
dc.contributor.author |
Muirhead, Roslyn |
|
dc.contributor.author |
Poppitt, Sally |
|
dc.contributor.author |
Pietiläinen, Kirsi H |
|
dc.contributor.author |
Adam, Tanja |
|
dc.contributor.author |
Taylor, Moira A |
|
dc.contributor.author |
Handjiev, Svetoslav |
|
dc.contributor.author |
McNarry, Melitta A |
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dc.contributor.author |
Hansen, Sylvia |
|
dc.contributor.author |
Brodie, Shannon |
|
dc.contributor.author |
Silvestre, Marta P |
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dc.contributor.author |
Macdonald, Ian A |
|
dc.contributor.author |
Boyadjieva, Nadka |
|
dc.contributor.author |
Mackintosh, Kelly A |
|
dc.contributor.author |
Schlicht, Wolfgang |
|
dc.contributor.author |
Liu, Amy |
|
dc.contributor.author |
Larsen, Thomas M |
|
dc.contributor.author |
Fogelholm, Mikael |
|
dc.contributor.author |
Raben, Anne |
|
dc.contributor.author |
Martinez, J Alfredo |
|
dc.coverage.spatial |
Switzerland |
|
dc.date.accessioned |
2022-04-22T00:22:43Z |
|
dc.date.available |
2022-04-22T00:22:43Z |
|
dc.date.issued |
2021-1 |
|
dc.identifier.citation |
Frontiers in nutrition 8:733697 Jan 2021 |
|
dc.identifier.issn |
2296-861X |
|
dc.identifier.uri |
https://hdl.handle.net/2292/58766 |
|
dc.description.abstract |
<b>Background:</b> Individuals with pre-diabetes are commonly overweight and benefit from dietary and physical activity strategies aimed at decreasing body weight and hyperglycemia. Early insulin resistance can be estimated <i>via</i> the triglyceride glucose index {TyG = Ln [TG (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2]} and the hypertriglyceridemic-high waist phenotype (TyG-waist), based on TyG x waist circumference (WC) measurements. Both indices may be useful for implementing personalized metabolic management. In this secondary analysis of a randomized controlled trial (RCT), we aimed to determine whether the differences in baseline TyG values and TyG-waist phenotype predicted individual responses to type-2 diabetes (T2D) prevention programs. <b>Methods:</b> The present <i>post-hoc</i> analyses were conducted within the Prevention of Diabetes through Lifestyle intervention and population studies in Europe and around the world (PREVIEW) study completers (<i>n</i> = 899), a multi-center RCT conducted in eight countries (NCT01777893). The study aimed to reduce the incidence of T2D in a population with pre-diabetes during a 3-year randomized intervention with two sequential phases. The first phase was a 2-month weight loss intervention to achieve ≥8% weight loss. The second phase was a 34-month weight loss maintenance intervention with two diets providing different amounts of protein and different glycemic indices, and two physical activity programs with different exercise intensities in a 2 x 2 factorial design. On investigation days, we assessed anthropometrics, glucose/lipid metabolism markers, and diet and exercise questionnaires under standardized procedures. <b>Results:</b> Diabetes-related markers improved during all four lifestyle interventions. Higher baseline TyG index (<i>p</i> < 0.001) was associated with greater reductions in body weight, fasting glucose, and triglyceride (TG), while a high TyG-waist phenotype predicted better TG responses, particularly in those randomized to physical activity (PA) of moderate intensity. <b>Conclusions:</b> Two novel indices of insulin resistance (TyG and TyG-waist) may allow for a more personalized approach to avoiding progression to T2D. <b>Clinical Trial Registration:</b> https://clinicaltrials.gov/ct2/show/NCT01777893 reference, identifier: NCT01777893. |
|
dc.format.medium |
Electronic-eCollection |
|
dc.language |
eng |
|
dc.publisher |
Frontiers Media SA |
|
dc.relation.ispartofseries |
Frontiers in nutrition |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
carbohydrate metabolism |
|
dc.subject |
diabetes |
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dc.subject |
hypertriglyceridemic-waist phenotype |
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dc.subject |
lipid markers |
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dc.subject |
obesity |
|
dc.subject |
pre-diabetes |
|
dc.subject |
precision nutrition |
|
dc.subject |
triglycerides (PubChem CID: 5460048) |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Nutrition & Dietetics |
|
dc.subject |
obesity |
|
dc.subject |
pre-diabetes |
|
dc.subject |
triglycerides (PubChem CID |
|
dc.subject |
5460048) |
|
dc.subject |
hypertriglyceridemic-waist phenotype |
|
dc.subject |
precision nutrition |
|
dc.subject |
diabetes |
|
dc.subject |
carbohydrate metabolism |
|
dc.subject |
lipid markers |
|
dc.subject |
FASTING PLASMA-GLUCOSE |
|
dc.subject |
WEIGHT-LOSS |
|
dc.subject |
PERSONALIZED NUTRITION |
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dc.subject |
RISK-FACTORS |
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dc.subject |
TYG INDEX |
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dc.subject |
EXERCISE |
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dc.subject |
DIET |
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dc.subject |
ASSOCIATION |
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dc.subject |
POPULATION |
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dc.subject |
PREVENTION |
|
dc.subject |
1001 Agricultural Biotechnology |
|
dc.subject |
1111 Nutrition and Dietetics |
|
dc.title |
Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention: A Controlled <i>Post-hoc</i> Trial. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.3389/fnut.2021.733697 |
|
pubs.begin-page |
733697 |
|
pubs.volume |
8 |
|
dc.date.updated |
2022-03-15T16:14:26Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/34790686 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
875245 |
|
dc.identifier.eissn |
2296-861X |
|
pubs.number |
ARTN 733697 |
|
pubs.online-publication-date |
2021-11-1 |
|