dc.contributor.author |
Cait, Alissa |
|
dc.contributor.author |
Mooney, Anna |
|
dc.contributor.author |
Poyntz, Hazel |
|
dc.contributor.author |
Shortt, Nick |
|
dc.contributor.author |
Jones, Angela |
|
dc.contributor.author |
Gestin, Aurélie |
|
dc.contributor.author |
Gell, Katie |
|
dc.contributor.author |
Grooby, Alix |
|
dc.contributor.author |
O'Sullivan, David |
|
dc.contributor.author |
Tang, Jeffry S |
|
dc.contributor.author |
Young, Wayne |
|
dc.contributor.author |
Thayabaran, Darmiga |
|
dc.contributor.author |
Sparks, Jenny |
|
dc.contributor.author |
Ostapowicz, Tess |
|
dc.contributor.author |
Tay, Audrey |
|
dc.contributor.author |
Poppitt, Sally D |
|
dc.contributor.author |
Elliott, Sarah |
|
dc.contributor.author |
Wakefield, Georgia |
|
dc.contributor.author |
Parry-Strong, Amber |
|
dc.contributor.author |
Ralston, Jacqui |
|
dc.contributor.author |
Beasley, Richard |
|
dc.contributor.author |
Weatherall, Mark |
|
dc.contributor.author |
Braithwaite, Irene |
|
dc.contributor.author |
Forbes-Blom, Elizabeth |
|
dc.contributor.author |
Gasser, Olivier |
|
dc.coverage.spatial |
Switzerland |
|
dc.date.accessioned |
2022-04-25T21:17:03Z |
|
dc.date.available |
2022-04-25T21:17:03Z |
|
dc.date.issued |
2021-1 |
|
dc.identifier.citation |
Frontiers in immunology 12:765528 Jan 2021 |
|
dc.identifier.issn |
1664-3224 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/58768 |
|
dc.description.abstract |
Influenza vaccination is an effective public health measure to reduce the risk of influenza illness, particularly when the vaccine is well matched to circulating strains. Notwithstanding, the efficacy of influenza vaccination varies greatly among vaccinees due to largely unknown immunological determinants, thereby dampening population-wide protection. Here, we report that dietary fibre may play a significant role in humoral vaccine responses. We found dietary fibre intake and the abundance of fibre-fermenting intestinal bacteria to be positively correlated with humoral influenza vaccine-specific immune responses in human vaccinees, albeit without reaching statistical significance. Importantly, this correlation was largely driven by first-time vaccinees; prior influenza vaccination negatively correlated with vaccine immunogenicity. In support of these observations, dietary fibre consumption significantly enhanced humoral influenza vaccine responses in mice, where the effect was mechanistically linked to short-chain fatty acids, the bacterial fermentation product of dietary fibre. Overall, these findings may bear significant importance for emerging infectious agents, such as COVID-19, and associated <i>de novo</i> vaccinations. |
|
dc.format.medium |
Electronic-eCollection |
|
dc.language |
eng |
|
dc.publisher |
Frontiers Media SA |
|
dc.relation.ispartofseries |
Frontiers in immunology |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Animals |
|
dc.subject |
Humans |
|
dc.subject |
Mice |
|
dc.subject |
Orthomyxoviridae |
|
dc.subject |
Fatty Acids, Volatile |
|
dc.subject |
Influenza Vaccines |
|
dc.subject |
Vaccination |
|
dc.subject |
Seasons |
|
dc.subject |
Fermentation |
|
dc.subject |
Dietary Fiber |
|
dc.subject |
Adolescent |
|
dc.subject |
Adult |
|
dc.subject |
Middle Aged |
|
dc.subject |
Female |
|
dc.subject |
Male |
|
dc.subject |
Influenza, Human |
|
dc.subject |
Young Adult |
|
dc.subject |
Immunity, Humoral |
|
dc.subject |
Gastrointestinal Microbiome |
|
dc.subject |
Immunogenicity, Vaccine |
|
dc.subject |
fibre |
|
dc.subject |
influenza |
|
dc.subject |
microbiome |
|
dc.subject |
short chain fatty acids (SCFA) |
|
dc.subject |
vaccine |
|
dc.subject |
Adolescent |
|
dc.subject |
Adult |
|
dc.subject |
Animals |
|
dc.subject |
Dietary Fiber |
|
dc.subject |
Fatty Acids, Volatile |
|
dc.subject |
Female |
|
dc.subject |
Fermentation |
|
dc.subject |
Gastrointestinal Microbiome |
|
dc.subject |
Humans |
|
dc.subject |
Immunity, Humoral |
|
dc.subject |
Immunogenicity, Vaccine |
|
dc.subject |
Influenza Vaccines |
|
dc.subject |
Influenza, Human |
|
dc.subject |
Male |
|
dc.subject |
Mice |
|
dc.subject |
Middle Aged |
|
dc.subject |
Orthomyxoviridae |
|
dc.subject |
Seasons |
|
dc.subject |
Vaccination |
|
dc.subject |
Young Adult |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Immunology |
|
dc.subject |
fibre |
|
dc.subject |
microbiome |
|
dc.subject |
influenza |
|
dc.subject |
vaccine |
|
dc.subject |
short chain fatty acids (SCFA) |
|
dc.subject |
CHAIN FATTY-ACIDS |
|
dc.subject |
ANTIBODY-RESPONSES |
|
dc.subject |
IMMUNE-RESPONSE |
|
dc.subject |
GUT MICROBIOME |
|
dc.subject |
HEALTH |
|
dc.subject |
IMPACT |
|
dc.subject |
VIRUS |
|
dc.subject |
IMMUNOGENICITY |
|
dc.subject |
1107 Immunology |
|
dc.subject |
1108 Medical Microbiology |
|
dc.title |
Potential Association Between Dietary Fibre and Humoral Response to the Seasonal Influenza Vaccine. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.3389/fimmu.2021.765528 |
|
pubs.begin-page |
765528 |
|
pubs.volume |
12 |
|
dc.date.updated |
2022-03-15T17:12:03Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/34868014 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
876255 |
|
dc.identifier.eissn |
1664-3224 |
|
pubs.number |
ARTN 765528 |
|
pubs.online-publication-date |
2021-11-17 |
|