Systematic Comparison of Left Ventricular Geometry Between 3D-Echocardiography and Cardiac Magnetic Resonance Imaging.

Show simple item record Zhao, Debbie Quill, Gina M Gilbert, Kathleen Wang, Vicky Y Houle, Helene C Legget, Malcolm E Ruygrok, Peter N Doughty, Robert N Pedrosa, João D'hooge, Jan Young, Alistair A Nash, Martyn P
dc.coverage.spatial Switzerland 2022-04-25T21:58:44Z 2022-04-25T21:58:44Z 2021-1
dc.identifier.citation Frontiers in cardiovascular medicine 8:728205 Jan 2021
dc.identifier.issn 2297-055X
dc.description.abstract <b>Aims:</b> Left ventricular (LV) volumes estimated using three-dimensional echocardiography (3D-echo) have been reported to be smaller than those measured using cardiac magnetic resonance (CMR) imaging, but the underlying causes are not well-understood. We investigated differences in regional LV anatomy derived from these modalities and related subsequent findings to image characteristics. <b>Methods and Results:</b> Seventy participants (18 patients and 52 healthy participants) were imaged with 3D-echo and CMR (<1 h apart). Three-dimensional left ventricular models were constructed at end-diastole (ED) and end-systole (ES) from both modalities using previously validated software, enabling the fusion of CMR with 3D-echo by rigid registration. Regional differences were evaluated as mean surface distances for each of the 17 American Heart Association segments, and by comparing contours superimposed on images from each modality. In comparison to CMR-derived models, 3D-echo models underestimated LV end-diastolic volume (EDV) by -16 ± 22, -1 ± 25, and -18 ± 24 ml across three independent analysis methods. Average surface distance errors were largest in the basal-anterolateral segment (11-15 mm) and smallest in the mid-inferoseptal segment (6 mm). Larger errors were associated with signal dropout in anterior regions and the appearance of trabeculae at the lateral wall. <b>Conclusions:</b> Fusion of CMR and 3D-echo provides insight into the causes of volume underestimation by 3D-echo. Systematic signal dropout and differences in appearances of trabeculae lead to discrepancies in the delineation of LV geometry at anterior and lateral regions. A better understanding of error sources across modalities may improve correlation of clinical indices between 3D-echo and CMR.
dc.format.medium Electronic-eCollection
dc.language eng
dc.publisher Frontiers Media SA
dc.relation.ispartofseries Frontiers in cardiovascular medicine
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.subject 3D-echocardiography
dc.subject cardiac MRI
dc.subject image registration
dc.subject left ventricle
dc.subject reproducibility
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Cardiac & Cardiovascular Systems
dc.subject Cardiovascular System & Cardiology
dc.subject 3D-echocardiography
dc.subject cardiac MRI
dc.subject left ventricle
dc.subject image registration
dc.subject reproducibility
dc.subject HEART
dc.title Systematic Comparison of Left Ventricular Geometry Between 3D-Echocardiography and Cardiac Magnetic Resonance Imaging.
dc.type Journal Article
dc.identifier.doi 10.3389/fcvm.2021.728205
pubs.begin-page 728205
pubs.volume 8 2022-03-16T08:09:03Z
dc.rights.holder Copyright: The author en
pubs.publication-status Published
dc.rights.accessrights en
pubs.subtype research-article
pubs.subtype Journal Article
pubs.elements-id 869613
dc.identifier.eissn 2297-055X
pubs.number ARTN 728205 2021-9-20

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