Treatment of Impetigo with Antiseptics- Replacing Antibiotics (TIARA) Trial- a single blind randomised controlled trial in school health clinics within socioeconomically disadvantaged communities in New Zealand

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dc.contributor.author Primhak, Sarah
dc.contributor.author Gataua, Alicia
dc.contributor.author Purvis, Diana
dc.contributor.author Thomp, John MD
dc.contributor.author Walker, Cameron
dc.contributor.author Best, Emma
dc.contributor.author Leversha, Alison
dc.date.accessioned 2022-05-02T03:40:55Z
dc.date.available 2022-05-02T03:40:55Z
dc.date.issued 2021-11-08
dc.identifier.citation Research Square 08 Nov 2021. (271692).
dc.identifier.uri https://hdl.handle.net/2292/58825
dc.description.abstract <h4>Background: </h4> Impetigo is a common and contagious bacterial skin infection, affecting children worldwide but it is particularly prevalent in deprived communities. In New Zealand widespread prescribing of the topical antibiotic fusidic acid had led to an increase in antimicrobial resistance of Staphylococcus aureus . Alternative treatments are urgently being sought and as impetigo is a superficial infection, it has been suggested that topical antiseptics such as hydrogen peroxide or simple wound care alone may treat impetigo while avoiding the risk of increased antimicrobial resistance.MethodsThis protocol for a non-inferiority, single-blind randomised controlled trial compares topical fusidic acid with topical hydrogen peroxide and with simple wound care in the treatment of childhood impetigo. Participants are randomised to one of the three treatments for five days and the primary outcome is clinical improvement. This is assessed through paired photographs analysed by graders blinded to treatment arm. The trial is based in school health clinics in an urban centre in New Zealand. Comparison of antimicrobial resistance patterns pre- and post-treatment is also performed.DiscussionSpecial note is made of the need to involve the communities most affected by impetigo in the design and implementation of the clinical trial in order to recruit the children most in need of safe and effective treatments. Trial registration: Australian New Zealand Clinical Trials Registry (ANZCTR) 12616000356460
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dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Clinical Research
dc.subject Clinical Trials and Supportive Activities
dc.subject Infectious Diseases
dc.subject Antimicrobial Resistance
dc.subject 6.1 Pharmaceuticals
dc.subject 5.1 Pharmaceuticals
dc.subject Infection
dc.title Treatment of Impetigo with Antiseptics- Replacing Antibiotics (TIARA) Trial- a single blind randomised controlled trial in school health clinics within socioeconomically disadvantaged communities in New Zealand
dc.type Report
dc.identifier.doi 10.21203/rs.3.rs-271692/v1
dc.date.updated 2022-04-10T20:14:20Z
dc.rights.holder Copyright: The author en
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Working Paper
pubs.elements-id 874945
pubs.org-id Engineering
pubs.org-id Medical and Health Sciences
pubs.org-id School of Medicine
pubs.org-id Paediatrics Child & Youth Hlth
pubs.org-id Engineering Science
pubs.number 271692
pubs.record-created-at-source-date 2022-04-11


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