dc.contributor.author |
Ramji, Rajan |
|
dc.contributor.author |
Oakley, Amanda |
|
dc.contributor.author |
Rademaker, Marius |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2022-05-06T02:29:48Z |
|
dc.date.available |
2022-05-06T02:29:48Z |
|
dc.date.issued |
2021-03 |
|
dc.identifier.citation |
(2021). Pigment Cell and Melanoma Research, 34(2), 163-173. |
|
dc.identifier.issn |
1755-1471 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/59011 |
|
dc.description.abstract |
Sequential digital dermoscopic imaging (SDDI) compares surface microscopy images of skin lesions over multiple time points. We utilized a retrospective SDDI cohort to investigate the development of dermoscopic features associated with malignancy in melanoma in situ (MIS). A total of 124 in situ melanomas were assessed from 110 Caucasian patients aged ≥18 years, with ≥2 serial images obtained between 1999 and 2017 and followed for a mean 41 months (3-142). As a positive control group, 58 invasive melanomas from 53 patients were also reviewed. Change in MIS size or number of colours correlated to time (both p < .001). The odds of MIS displaying ≥3 clues to malignancy also correlated to time (OR 5.6-52.1) (p < .05). 75% of in situ melanomas matched a dermoscopic subtype on final imaging. While a clinically significant minority of in situ melanomas were unchanged or lost dermoscopic features, lesions predominantly increased in morphological complexity over time. Longer follow-up periods allow dermoscopic features associated with malignancy and histopathological progression to develop. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Wiley |
|
dc.relation.ispartofseries |
Pigment cell & melanoma research |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Humans |
|
dc.subject |
Melanoma |
|
dc.subject |
Carcinoma in Situ |
|
dc.subject |
Neoplasm Invasiveness |
|
dc.subject |
Dermoscopy |
|
dc.subject |
Prognosis |
|
dc.subject |
Retrospective Studies |
|
dc.subject |
Follow-Up Studies |
|
dc.subject |
Adolescent |
|
dc.subject |
Adult |
|
dc.subject |
Aged |
|
dc.subject |
Aged, 80 and over |
|
dc.subject |
Middle Aged |
|
dc.subject |
Female |
|
dc.subject |
Male |
|
dc.subject |
Young Adult |
|
dc.subject |
early detection |
|
dc.subject |
melanoma in situ |
|
dc.subject |
revised pattern analysis |
|
dc.subject |
sequential digital dermoscopic imaging |
|
dc.subject |
Cancer |
|
dc.subject |
Clinical Research |
|
dc.subject |
4.2 Evaluation of markers and technologies |
|
dc.subject |
06 Biological Sciences |
|
dc.subject |
11 Medical and Health Sciences |
|
dc.title |
Morphological evolution in melanoma in situ using revised pattern analysis. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1111/pcmr.12923 |
|
pubs.issue |
2 |
|
pubs.begin-page |
163 |
|
pubs.volume |
34 |
|
dc.date.updated |
2022-04-18T20:17:40Z |
|
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
32860494 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/32860494 |
|
pubs.end-page |
173 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.subtype |
Observational Study |
|
pubs.elements-id |
852089 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Medicine Department |
|
dc.identifier.eissn |
1755-148X |
|
pubs.record-created-at-source-date |
2022-04-19 |
|
pubs.online-publication-date |
2020-09-14 |
|