The associations between maternal BMI and gestational weight gain and health outcomes in offspring at age 1 and 7 years.

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dc.contributor.author Chiavaroli, Valentina
dc.contributor.author Hopkins, Sarah A
dc.contributor.author Biggs, Janene B
dc.contributor.author Rodrigues, Raquel O
dc.contributor.author Seneviratne, Sumudu N
dc.contributor.author Baldi, James C
dc.contributor.author McCowan, Lesley ME
dc.contributor.author Cutfield, Wayne S
dc.contributor.author Hofman, Paul L
dc.contributor.author Derraik, José GB
dc.coverage.spatial England
dc.date.accessioned 2022-05-10T02:37:02Z
dc.date.available 2022-05-10T02:37:02Z
dc.date.issued 2021-10-21
dc.identifier.citation (2021). Scientific Reports, 11(1), 20865-.
dc.identifier.issn 2045-2322
dc.identifier.uri https://hdl.handle.net/2292/59116
dc.description.abstract In secondary analyses of a randomised controlled trial of exercise during pregnancy, we examined associations between mid-pregnancy maternal body mass index (BMI) and excessive gestational weight gain (GWG) with offspring health. Follow-up data were available on 57 mother-child pairs at 1-year and 52 pairs at 7-year follow-ups. Clinical assessments included body composition and fasting blood tests. At age 1 year, increased maternal BMI in mid-gestation was associated with greater weight standard deviation scores (SDS) in the offspring (p = 0.035), with no observed associations for excessive GWG. At age 7 years, greater maternal BMI was associated with increased weight SDS (p < 0.001), BMI SDS (p = 0.005), and total body fat percentage (p = 0.037) in their children. Irrespective of maternal BMI, children born to mothers with excessive GWG had greater abdominal adiposity (p = 0.043) and less favourable lipid profile (lower HDL-C and higher triglycerides). At 7 years, maternal BMI and excessive GWG had compounded adverse associations with offspring adiposity. Compared to offspring of mothers with overweight/obesity plus excessive GWG, children of normal-weight mothers with adequate and excessive GWG were 0.97 and 0.64 SDS lighter (p = 0.002 and p = 0.014, respectively), and 0.98 and 0.63 SDS leaner (p = 0.001 and p = 0.014, respectively). Both greater maternal BMI in mid-pregnancy and excessive GWG were independently associated with increased adiposity in offspring at 7 years.
dc.format.medium Electronic
dc.language eng
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartofseries Scientific reports
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Humans
dc.subject Birth Weight
dc.subject Blood Glucose
dc.subject Lipids
dc.subject Body Mass Index
dc.subject Follow-Up Studies
dc.subject Body Composition
dc.subject Pregnancy
dc.subject Child
dc.subject Child, Preschool
dc.subject Infant
dc.subject Female
dc.subject Male
dc.subject Child Health
dc.subject Gestational Weight Gain
dc.subject Nutrition
dc.subject Obesity
dc.subject Pediatric
dc.subject Prevention
dc.subject Cardiovascular
dc.subject Reproductive health and childbirth
dc.subject Metabolic and endocrine
dc.subject Science & Technology
dc.subject Multidisciplinary Sciences
dc.subject Science & Technology - Other Topics
dc.subject LONG-TERM HEALTH
dc.subject BODY-MASS INDEX
dc.subject BLOOD-PRESSURE
dc.subject CHILDHOOD OBESITY
dc.subject BIRTH
dc.subject OVERWEIGHT
dc.subject STANDARDS
dc.subject CHILDREN
dc.title The associations between maternal BMI and gestational weight gain and health outcomes in offspring at age 1 and 7 years.
dc.type Journal Article
dc.identifier.doi 10.1038/s41598-021-99869-7
pubs.issue 1
pubs.begin-page 20865
pubs.volume 11
dc.date.updated 2022-04-19T21:12:39Z
dc.rights.holder Copyright: The author en
dc.identifier.pmid 34675369 (pubmed)
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/34675369
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Research Support, Non-U.S. Gov't
pubs.subtype research-article
pubs.subtype Randomized Controlled Trial
pubs.subtype Journal Article
pubs.elements-id 871092
pubs.org-id Liggins Institute
pubs.org-id Medical and Health Sciences
pubs.org-id School of Medicine
pubs.org-id Obstetrics and Gynaecology
pubs.org-id Paediatrics Child & Youth Hlth
pubs.org-id Psychological Medicine Dept
dc.identifier.eissn 2045-2322
dc.identifier.pii 10.1038/s41598-021-99869-7
pubs.number 20865
pubs.record-created-at-source-date 2022-04-20
pubs.online-publication-date 2021-10-21


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