dc.contributor.author |
Scott, Oliver William |
|
dc.contributor.author |
Tin Tin, Sandar |
|
dc.contributor.author |
Elwood, J Mark |
|
dc.contributor.author |
Cavadino, Alana |
|
dc.contributor.author |
Habel, Laurel A |
|
dc.contributor.author |
Kuper-Hommel, Marion |
|
dc.contributor.author |
Campbell, Ian |
|
dc.contributor.author |
Lawrenson, Ross |
|
dc.coverage.spatial |
Netherlands |
|
dc.date.accessioned |
2022-05-10T04:21:12Z |
|
dc.date.available |
2022-05-10T04:21:12Z |
|
dc.date.issued |
2022-03-14 |
|
dc.identifier.citation |
(2022). Breast Cancer Research and Treatment, 1-11. |
|
dc.identifier.issn |
0167-6806 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/59144 |
|
dc.description.abstract |
<h4>Purpose</h4>Beta blockers (BB) have been associated with improved, worsened, or unchanged breast cancer outcomes in previous studies. This study examines the association between the post-diagnostic use of BBs and death from breast cancer in a large, representative sample of New Zealand (NZ) women with breast cancer.<h4>Methods</h4>Women diagnosed with a first primary breast cancer between 2007 and 2016 were identified from four population-based regional NZ breast cancer registries and linked to national pharmaceutical data, hospital discharges, and death records. The median follow-up time was 4.51 years. Cox proportional hazard models were used to estimate the hazard of breast cancer-specific death (BCD) associated with any post-diagnostic BB use.<h4>Results</h4>Of the 14,976 women included in analyses, 21% used a BB after diagnosis. BB use (vs non-use) was associated with a small and nonstatistically significant increased risk of BCD (adjusted hazard ratio: 1.11; 95% CI 0.95-1.29). A statistically significant increased risk confined to short-term use (0-3 months) was seen (HR = 1.40; 1.14-1.73), and this risk steadily decreased with increasing duration of use and became a statistically significant protective effect at 3 + years of use (HR = 0.55; 0.34-0.88).<h4>Conclusion</h4>Our findings suggest that any increased risk associated with BB use may be driven by risk in the initial few months of use. Long-term BB use may be associated with a reduction in BCD. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Springer Science and Business Media LLC |
|
dc.relation.ispartofseries |
Breast cancer research and treatment |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Beta blockers |
|
dc.subject |
Breast cancer |
|
dc.subject |
Cohort study |
|
dc.subject |
Mortality |
|
dc.subject |
Pharmacoepidemiology |
|
dc.subject |
Cancer |
|
dc.subject |
Prevention |
|
dc.subject |
Clinical Research |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
1112 Oncology and Carcinogenesis |
|
dc.title |
Post-diagnostic beta blocker use and breast cancer-specific mortality: a population-based cohort study. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1007/s10549-022-06528-0 |
|
pubs.begin-page |
1 |
|
dc.date.updated |
2022-04-04T12:56:40Z |
|
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
35286523 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/35286523 |
|
pubs.end-page |
11 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.elements-id |
889392 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Population Health |
|
pubs.org-id |
Epidemiology & Biostatistics |
|
pubs.org-id |
School of Medicine |
|
pubs.org-id |
Surgery Department |
|
dc.identifier.eissn |
1573-7217 |
|
dc.identifier.pii |
10.1007/s10549-022-06528-0 |
|
pubs.record-created-at-source-date |
2022-04-05 |
|
pubs.online-publication-date |
2022-03-14 |
|