"CLipP"ing on lipids to generate antibacterial lipopeptides.

Yim, Victor; Kavianinia, Iman; Knottenbelt, Melanie K; Ferguson, Scott A; Cook, Gregory M; Swift, Simon; Chakraborty, Aparajita; Allison, Jane R; Cameron, Alan J; Harris, Paul WR; Brimble, Margaret A

dc.contributor.author	Yim, Victor
dc.contributor.author	Kavianinia, Iman
dc.contributor.author	Knottenbelt, Melanie K
dc.contributor.author	Ferguson, Scott A
dc.contributor.author	Cook, Gregory M
dc.contributor.author	Swift, Simon
dc.contributor.author	Chakraborty, Aparajita
dc.contributor.author	Allison, Jane R
dc.contributor.author	Cameron, Alan J
dc.contributor.author	Harris, Paul WR
dc.contributor.author	Brimble, Margaret A
dc.coverage.spatial	England
dc.date.accessioned	2022-05-11T03:51:32Z
dc.date.available	2022-05-11T03:51:32Z
dc.date.issued	2020-05-20
dc.identifier.citation	(2020). Chemical Science, 11(22), 5759-5765.
dc.identifier.issn	2041-6520
dc.identifier.uri	https://hdl.handle.net/2292/59177
dc.description.abstract	We herein report the synthesis and biological and computational evaluation of 12 linear analogues of the cyclic lipopeptide battacin, enabled by Cysteine Lipidation on a Peptide or Amino Acid (CLipPA) technology. Several of the novel "CLipP"ed lipopeptides exhibited low micromolar MICs and MBCs against both Gram-negative and Gram-positive bacteria. The mechanism of action was then simulated with the MIC data using computational methods.
dc.format.medium	Electronic
dc.language	eng
dc.publisher	Royal Society of Chemistry (RSC)
dc.relation.ispartofseries	Chemical science
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.rights.uri	https://creativecommons.org/licenses/by-nc/3.0/
dc.subject	Networking and Information Technology R&D
dc.subject	Science & Technology
dc.subject	Physical Sciences
dc.subject	Chemistry, Multidisciplinary
dc.subject	Chemistry
dc.subject	BATTACIN LIPOPEPTIDES
dc.subject	PEPTIDES
dc.subject	CYSTEINE
dc.subject	03 Chemical Sciences
dc.title	"CLipP"ing on lipids to generate antibacterial lipopeptides.
dc.type	Journal Article
dc.identifier.doi	10.1039/d0sc01814g
pubs.issue	22
pubs.begin-page	5759
pubs.volume	11
dc.date.updated	2022-04-27T23:06:26Z
dc.rights.holder	Copyright: The author	en
dc.identifier.pmid	34094080 (pubmed)
pubs.author-url	https://www.ncbi.nlm.nih.gov/pubmed/34094080
pubs.end-page	5765
pubs.publication-status	Published
dc.rights.accessrights	http://purl.org/eprint/accessRights/OpenAccess	en
pubs.subtype	research-article
pubs.subtype	Journal Article
pubs.elements-id	804953
pubs.org-id	Medical and Health Sciences
pubs.org-id	Science
pubs.org-id	Chemistry
pubs.org-id	Biological Sciences
pubs.org-id	Science Research
pubs.org-id	Medical Sciences
pubs.org-id	Molecular Medicine
pubs.org-id	Maurice Wilkins Centre (2010-2014)
dc.identifier.eissn	2041-6539
dc.identifier.pii	d0sc01814g
pubs.record-created-at-source-date	2022-04-28
pubs.online-publication-date	2020