"CLipP"ing on lipids to generate antibacterial lipopeptides.

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dc.contributor.author Yim, Victor
dc.contributor.author Kavianinia, Iman
dc.contributor.author Knottenbelt, Melanie K
dc.contributor.author Ferguson, Scott A
dc.contributor.author Cook, Gregory M
dc.contributor.author Swift, Simon
dc.contributor.author Chakraborty, Aparajita
dc.contributor.author Allison, Jane R
dc.contributor.author Cameron, Alan J
dc.contributor.author Harris, Paul WR
dc.contributor.author Brimble, Margaret A
dc.coverage.spatial England
dc.date.accessioned 2022-05-11T03:51:32Z
dc.date.available 2022-05-11T03:51:32Z
dc.date.issued 2020-05-20
dc.identifier.citation (2020). Chemical Science, 11(22), 5759-5765.
dc.identifier.issn 2041-6520
dc.identifier.uri https://hdl.handle.net/2292/59177
dc.description.abstract We herein report the synthesis and biological and computational evaluation of 12 linear analogues of the cyclic lipopeptide battacin, enabled by Cysteine Lipidation on a Peptide or Amino Acid (CLipPA) technology. Several of the novel "CLipP"ed lipopeptides exhibited low micromolar MICs and MBCs against both Gram-negative and Gram-positive bacteria. The mechanism of action was then simulated with the MIC data using computational methods.
dc.format.medium Electronic
dc.language eng
dc.publisher Royal Society of Chemistry (RSC)
dc.relation.ispartofseries Chemical science
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.rights.uri https://creativecommons.org/licenses/by-nc/3.0/
dc.subject Networking and Information Technology R&D
dc.subject Science & Technology
dc.subject Physical Sciences
dc.subject Chemistry, Multidisciplinary
dc.subject Chemistry
dc.subject PEPTIDES
dc.subject CYSTEINE
dc.subject 03 Chemical Sciences
dc.title "CLipP"ing on lipids to generate antibacterial lipopeptides.
dc.type Journal Article
dc.identifier.doi 10.1039/d0sc01814g
pubs.issue 22
pubs.begin-page 5759
pubs.volume 11
dc.date.updated 2022-04-27T23:06:26Z
dc.rights.holder Copyright: The author en
dc.identifier.pmid 34094080 (pubmed)
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/34094080
pubs.end-page 5765
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype research-article
pubs.subtype Journal Article
pubs.elements-id 804953
pubs.org-id Medical and Health Sciences
pubs.org-id Science
pubs.org-id Chemistry
pubs.org-id Biological Sciences
pubs.org-id Science Research
pubs.org-id Medical Sciences
pubs.org-id Molecular Medicine
pubs.org-id Maurice Wilkins Centre (2010-2014)
dc.identifier.eissn 2041-6539
dc.identifier.pii d0sc01814g
pubs.record-created-at-source-date 2022-04-28
pubs.online-publication-date 2020

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