dc.contributor.author |
Denisenko, Elena |
|
dc.contributor.author |
Ho, Daniel |
|
dc.contributor.author |
Tamgue, Ousman |
|
dc.contributor.author |
Ozturk, Mumin |
|
dc.contributor.author |
Suzuki, Harukazu |
|
dc.contributor.author |
Brombacher, Frank |
|
dc.contributor.author |
Guler, Reto |
|
dc.contributor.author |
Schmeier, Sebastian |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2022-05-11T22:40:16Z |
|
dc.date.available |
2022-05-11T22:40:16Z |
|
dc.date.issued |
2016-10-25 |
|
dc.identifier.citation |
(2016). Database: the journal of biological databases and curation, 2016, baw138-. |
|
dc.identifier.issn |
1758-0463 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/59208 |
|
dc.description.abstract |
MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs) and other functional non-coding RNAs (ncRNAs) have emerged as pivotal regulators involved in multiple biological processes. Recently, ncRNA control of gene expression has been identified as a critical regulatory mechanism in the immune system. Despite the great efforts made to discover and characterize ncRNAs, the functional role for most remains unknown. To facilitate discoveries in ncRNA regulation of immune system-related processes, we developed the database of immunologically relevant ncRNAs and target genes (IRNdb). We integrated mouse data on predicted and experimentally supported ncRNA-target interactions, ncRNA and gene annotations, biological pathways and processes and experimental data in a uniform format with a user-friendly web interface. The current version of IRNdb documents 12 930 experimentally supported miRNA-target interactions between 724 miRNAs and 2427 immune-related mouse targets. In addition, we recorded 22 453 lncRNA-immune target and 377 PIWI-interacting RNA-immune target interactions. IRNdb is a comprehensive searchable data repository which will be of help in studying the role of ncRNAs in the immune system. Database URL:http://irndb.org. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
Oxford University Press (OUP) |
|
dc.relation.ispartofseries |
Database : the journal of biological databases and curation |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Genetics |
|
dc.subject |
Biotechnology |
|
dc.subject |
Generic health relevance |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Mathematical & Computational Biology |
|
dc.subject |
IMMUNE-SYSTEM |
|
dc.subject |
TARGET PREDICTION |
|
dc.subject |
GENE |
|
dc.subject |
MICRORNAS |
|
dc.subject |
EXPRESSION |
|
dc.subject |
PROTEINS |
|
dc.subject |
RESOURCE |
|
dc.subject |
ENCYCLOPEDIA |
|
dc.subject |
BIOGENESIS |
|
dc.subject |
GENOMICS |
|
dc.subject |
0804 Data Format |
|
dc.subject |
0807 Library and Information Studies |
|
dc.title |
IRNdb: the database of immunologically relevant non-coding RNAs. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1093/database/baw138 |
|
pubs.begin-page |
baw138 |
|
pubs.volume |
2016 |
|
dc.date.updated |
2022-04-27T02:04:34Z |
|
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
31414702 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/31414702 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
research-article |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
752411 |
|
pubs.org-id |
Liggins Institute |
|
dc.identifier.eissn |
1758-0463 |
|
dc.identifier.pii |
2630531 |
|
pubs.number |
ARTN baw138 |
|
pubs.record-created-at-source-date |
2022-04-27 |
|
pubs.online-publication-date |
2016-10-25 |
|