dc.contributor.author |
Manghat, Nathan E |
|
dc.contributor.author |
Robinson, Elizabeth |
|
dc.contributor.author |
Mitrousi, Konstantina |
|
dc.contributor.author |
Rodrigues, Jonathan CL |
|
dc.contributor.author |
Hinton, Thomas |
|
dc.contributor.author |
Paton, Julian FR |
|
dc.contributor.author |
Wise, Richard G |
|
dc.contributor.author |
Nightingale, Angus K |
|
dc.contributor.author |
Hart, Emma C |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2022-05-11T23:04:07Z |
|
dc.date.available |
2022-05-11T23:04:07Z |
|
dc.date.issued |
2022-03-16 |
|
dc.identifier.citation |
(2022). Hypertension, HYPERTENSIONAHA12118612-. |
|
dc.identifier.issn |
0194-911X |
|
dc.identifier.uri |
https://hdl.handle.net/2292/59213 |
|
dc.description.abstract |
<h4>Background</h4>Variants in the posterior anatomy of the cerebral circulation are associated with hypertension and lower cerebral blood flow in midlife (age ≈55 years); however, whether these variants are a result of aging or long-term exposure to high blood pressure is unclear. Additionally, the role these variants play in early onset of hypertension (<40 years) and poor cerebral perfusion in this population is unknown.<h4>Methods</h4>We retrospectively examined whether specific cerebrovascular variants (vertebral artery hypoplasia and absent/hypoplastic posterior communicating arteries (an incomplete posterior circle of Willis) measured via magnetic resonance angiography) were associated with a diagnosis of hypertension in 220 young adults (<40 years; n=164 primary hypertensive [mean age±SD, 32±6 years] and n=56 [30±6 years] normotensive adults). Whether cerebrovascular variants were associated with lower cerebral blood flow (phase-contrast angiography) was measured in the hypertensive group only (n=146).<h4>Results</h4>Binary logistic regression (adjusted for age, sex, and body mass index) showed that vertebral artery hypoplasia with an incomplete posterior circle of Willis was associated with hypertension diagnosis (<i>P</i><0.001, odds ratio; 11.79 [95% CI, 3.34-41.58]). Vertebral artery hypoplasia plus an incomplete circle of Willis was associated with lower cerebral blood flow in young adults with hypertension (<i>P</i>=0.0172).<h4>Conclusions</h4>Vertebral artery hypoplasia plus an incomplete posterior circle of Willis independently predicts hypertension in young adults suggesting that this variant is not acquired with aging into midlife. Importantly this variant combination was associated with lower cerebral perfusion, which may have long-term consequences on cerebrovascular health in young adults with hypertension. |
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dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Ovid Technologies (Wolters Kluwer Health) |
|
dc.relation.ispartofseries |
Hypertension (Dallas, Tex. : 1979) |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
blood pressure |
|
dc.subject |
circle of Willis |
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dc.subject |
hypertension |
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dc.subject |
vertebral artery |
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dc.subject |
young adults |
|
dc.subject |
Biomedical Imaging |
|
dc.subject |
Clinical Research |
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dc.subject |
Cardiovascular |
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dc.subject |
Aging |
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dc.subject |
Neurosciences |
|
dc.subject |
Brain Disorders |
|
dc.subject |
4.2 Evaluation of markers and technologies |
|
dc.subject |
1102 Cardiorespiratory Medicine and Haematology |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
1117 Public Health and Health Services |
|
dc.title |
Cerebrovascular Variants and the Role of the Selfish Brain in Young-Onset Hypertension. |
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dc.type |
Journal Article |
|
dc.identifier.doi |
10.1161/hypertensionaha.121.18612 |
|
pubs.begin-page |
HYPERTENSIONAHA12118612 |
|
dc.date.updated |
2022-04-04T21:25:38Z |
|
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
35291807 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/35291807 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Journal Article |
|
pubs.elements-id |
889604 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Medical Sciences |
|
pubs.org-id |
Physiology Division |
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dc.identifier.eissn |
1524-4563 |
|
pubs.record-created-at-source-date |
2022-04-05 |
|
pubs.online-publication-date |
2022-03-16 |
|