dc.contributor.author |
Waldvogel, HJ |
|
dc.contributor.author |
Biggins, FM |
|
dc.contributor.author |
Singh, A |
|
dc.contributor.author |
Arasaratnam, CJ |
|
dc.contributor.author |
Faull, RLM |
|
dc.coverage.spatial |
Netherlands |
|
dc.date.accessioned |
2022-05-19T04:55:46Z |
|
dc.date.available |
2022-05-19T04:55:46Z |
|
dc.date.issued |
2019-04 |
|
dc.identifier.citation |
(2019). Journal of Chemical Neuroanatomy, 97, 99-111. |
|
dc.identifier.issn |
0891-0618 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/59366 |
|
dc.description.abstract |
The hypoglossal nucleus, the nucleus of the twelfth cranial nerve, is located dorsally in the midline of the medulla oblongata. The hypoglossal nucleus contains lower motor neurons which innervate the tongue muscles that control tongue movements involved in speech production, swallowing, mastication and associated respiratory movements. GABAA and glycine receptors are heteropentameric ionotropic receptors that facilitate fast-response, inhibitory neurotransmission in the mammalian brain and spinal cord. We investigated the immunohistochemical distribution of the GABAA receptor α1, α2, β2,3 subunits and glycine receptors as well as their relationship to the vesicular GABA transporter (VGAT) in the human hypoglossal nucleus at the light and confocal laser scanning microscope levels. The results showed that all of the GABAA receptor subunits as well as glycine receptor display punctate labelling indicative of synapses on the soma and dendritic membranes of large neurons within the hypoglossal nucleus. On average, approximately 50% of glycine receptors were co localised with GABAA receptor α1 subunits. Also on average GABAA α2 and β2,3 subunits were colocalised with approximately 30% of glycine receptor subunits. VGAT positive terminals were associated with both GABAA and glycine receptor types. Both glycinergic and GABAergic positive puncta were found adjacent to VGAT terminal-like staining. These results suggest that inhibition of human hypoglossal motor neurons occurs not only through complex interaction of separated GABAAR and glycine receptor regions, but also through synapses containing both inhibitory receptor types co-existing at the same synaptic sites. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier BV |
|
dc.relation.ispartofseries |
Journal of chemical neuroanatomy |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Medulla Oblongata |
|
dc.subject |
Neurons |
|
dc.subject |
Motor Neurons |
|
dc.subject |
Hypoglossal Nerve |
|
dc.subject |
Humans |
|
dc.subject |
Receptors, GABA-A |
|
dc.subject |
Receptors, Glycine |
|
dc.subject |
Adult |
|
dc.subject |
Aged |
|
dc.subject |
Aged, 80 and over |
|
dc.subject |
Middle Aged |
|
dc.subject |
Female |
|
dc.subject |
Male |
|
dc.subject |
Antibodies |
|
dc.subject |
Confocal |
|
dc.subject |
GABA |
|
dc.subject |
Glycine |
|
dc.subject |
Human brain |
|
dc.subject |
Hypoglossal nucleus |
|
dc.subject |
Immunohistochemistry |
|
dc.subject |
Microscopy |
|
dc.subject |
Receptors |
|
dc.subject |
Subunits |
|
dc.subject |
XII cranial nerve nucleus |
|
dc.subject |
Neurosciences |
|
dc.subject |
Neurological |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Biochemistry & Molecular Biology |
|
dc.subject |
Neurosciences & Neurology |
|
dc.subject |
GAMMA-AMINOBUTYRIC-ACID |
|
dc.subject |
GENIOGLOSSUS MUSCLE |
|
dc.subject |
MOTOR NUCLEUS |
|
dc.subject |
SPINAL-CORD |
|
dc.subject |
A-RECEPTOR |
|
dc.subject |
ALPHA-1 SUBUNIT |
|
dc.subject |
BETA-SUBUNIT |
|
dc.subject |
IMMUNOHISTOCHEMICAL LOCALIZATION |
|
dc.subject |
DIFFERENTIAL LOCALIZATION |
|
dc.subject |
1109 Neurosciences |
|
dc.subject |
Clinical |
|
dc.subject |
Basic Science |
|
dc.subject |
Dental/Oral and Craniofacial Disease |
|
dc.title |
Variable colocalisation of GABAA receptor subunits and glycine receptors on neurons in the human hypoglossal nucleus. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.jchemneu.2019.02.005 |
|
pubs.begin-page |
99 |
|
pubs.volume |
97 |
|
dc.date.updated |
2022-04-10T23:47:32Z |
|
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
30825508 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/30825508 |
|
pubs.end-page |
111 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
766090 |
|
pubs.org-id |
Medical and Health Sciences |
|
pubs.org-id |
Medical Sciences |
|
pubs.org-id |
Anatomy and Medical Imaging |
|
dc.identifier.eissn |
1873-6300 |
|
dc.identifier.pii |
S0891-0618(18)30059-0 |
|
pubs.record-created-at-source-date |
2022-04-11 |
|