dc.contributor.author |
Mahfuz, Mustafa |
|
dc.contributor.author |
Das, Subhasish |
|
dc.contributor.author |
Mazumder, Ramendra Nath |
|
dc.contributor.author |
Masudur Rahman, M |
|
dc.contributor.author |
Haque, Rashidul |
|
dc.contributor.author |
Bhuiyan, Md Muzibur Rahman |
|
dc.contributor.author |
Akhter, Hasina |
|
dc.contributor.author |
Sarker, Md Shafiqul Alam |
|
dc.contributor.author |
Mondal, Dinesh |
|
dc.contributor.author |
Muaz, Syed Shafi Ahmed |
|
dc.contributor.author |
Karim, ASM Bazlul |
|
dc.contributor.author |
Borowitz, Stephen M |
|
dc.contributor.author |
Moskaluk, Christopher A |
|
dc.contributor.author |
Barratt, Michael J |
|
dc.contributor.author |
Petri, William A |
|
dc.contributor.author |
Gordon, Jeffrey I |
|
dc.contributor.author |
Ahmed, Tahmeed |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2022-05-23T01:37:39Z |
|
dc.date.available |
2022-05-23T01:37:39Z |
|
dc.date.issued |
2017-08-11 |
|
dc.identifier.citation |
(2017). BMJ Open, 7(8), e017768-. |
|
dc.identifier.issn |
2044-6055 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/59447 |
|
dc.description.abstract |
<h4>Introduction</h4>Environmental enteric dysfunction (EED) is a subacute inflammatory condition of the small intestinal mucosa with unclear aetiology that may account for more than 40% of all cases of stunting. Currently, there are no universally accepted protocols for the diagnosis, treatment and ultimately prevention of EED. The Bangladesh Environmental Enteric Dysfunction (BEED) study is designed to validate non-invasive biomarkers of EED with small intestinal biopsy, better understand disease pathogenesis and identify potential therapeutic targets for interventions designed to control EED and stunting.<h4>Methods and analysis</h4>The BEED study is a community-based intervention where participants are recruited from three cohorts: stunted children aged 12-18 months (length for age Z-score (LAZ) <-2), at risk of stunting children aged 12-18 months (LAZ <-1 to -2) and malnourished adults aged 18-45 years (body mass index <18.5 kg/m<sup>2</sup>). After screening, participants eligible for study provide faecal, urine and plasma specimens to quantify the levels of candidate EED biomarkers before and after receiving a nutritional intervention. Participants who fail to respond to nutritional therapy are considered as the candidates for upper gastrointestinal endoscopy with biopsy. Histopathological scoring for EED will be performed on biopsies obtained from several locations within the proximal small intestine. Candidate EED biomarkers will be correlated with nutritional status, the results of histochemical and immunohistochemical analyses of epithelial and lamina propria cell populations, plus assessments of microbial community structure.<h4>Ethics and dissemination</h4>Ethics approval was obtained in all participating institutes. Results of this study will be submitted for publication in peer-reviewed journals.<h4>Trial registration number</h4>ClinicalTrials.gov ID: NCT02812615. Registered on 21 June 2016. |
|
dc.format.medium |
Electronic |
|
dc.language |
eng |
|
dc.publisher |
BMJ |
|
dc.relation.ispartofseries |
BMJ open |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
|
dc.subject |
Intestinal Mucosa |
|
dc.subject |
Intestine, Small |
|
dc.subject |
Humans |
|
dc.subject |
Inflammatory Bowel Diseases |
|
dc.subject |
Child Nutrition Disorders |
|
dc.subject |
Malnutrition |
|
dc.subject |
Growth Disorders |
|
dc.subject |
Endoscopy, Gastrointestinal |
|
dc.subject |
Cohort Studies |
|
dc.subject |
Nutritional Status |
|
dc.subject |
Research Design |
|
dc.subject |
Adolescent |
|
dc.subject |
Adult |
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dc.subject |
Middle Aged |
|
dc.subject |
Child |
|
dc.subject |
Bangladesh |
|
dc.subject |
Female |
|
dc.subject |
Male |
|
dc.subject |
Young Adult |
|
dc.subject |
Biomarkers |
|
dc.subject |
Gastrointestinal Microbiome |
|
dc.subject |
Biomarker; Gut microbiota |
|
dc.subject |
EED |
|
dc.subject |
Nutritional intervention |
|
dc.subject |
Stunting |
|
dc.subject |
Upper gastro-intestinal endoscopy |
|
dc.subject |
Clinical Trials and Supportive Activities |
|
dc.subject |
Prevention |
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dc.subject |
Infectious Diseases |
|
dc.subject |
Digestive Diseases |
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dc.subject |
Clinical Research |
|
dc.subject |
Pediatric |
|
dc.subject |
Nutrition |
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dc.subject |
Oral and gastrointestinal |
|
dc.subject |
1103 Clinical Sciences |
|
dc.subject |
1117 Public Health and Health Services |
|
dc.subject |
1199 Other Medical and Health Sciences |
|
dc.title |
Bangladesh Environmental Enteric Dysfunction (BEED) study: protocol for a community-based intervention study to validate non-invasive biomarkers of environmental enteric dysfunction. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1136/bmjopen-2017-017768 |
|
pubs.issue |
8 |
|
pubs.begin-page |
e017768 |
|
pubs.volume |
7 |
|
dc.date.updated |
2022-04-14T00:11:22Z |
|
dc.rights.holder |
Copyright: The author |
en |
dc.identifier.pmid |
28801442 (pubmed) |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/28801442 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
protocol |
|
pubs.subtype |
Clinical Trial |
|
pubs.subtype |
Validation Study |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
895675 |
|
pubs.org-id |
Liggins Institute |
|
dc.identifier.eissn |
2044-6055 |
|
dc.identifier.pii |
bmjopen-2017-017768 |
|
pubs.record-created-at-source-date |
2022-04-14 |
|
pubs.online-publication-date |
2017-08-11 |
|