Effects of hypoxia and hyperoxia on venous capacity and compliance in healthy men and women.

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dc.contributor.author Fan, Jui-Lin
dc.contributor.author Sayegh, Ana Luiza C
dc.contributor.author Kaur, Manpreet
dc.contributor.author Dawes, Matthew
dc.contributor.author Paton, Julian FR
dc.contributor.author Fisher, James P
dc.coverage.spatial United States
dc.date.accessioned 2022-05-23T03:30:44Z
dc.date.available 2022-05-23T03:30:44Z
dc.date.issued 2022-03-23
dc.identifier.citation (2022). American Journal of Physiology: Regulatory, Integrative and Comparative Physiology.
dc.identifier.issn 0363-6119
dc.identifier.uri https://hdl.handle.net/2292/59468
dc.description.abstract Blood oxygen is an important modulator of arterial function, but its impact on peripheral venous function is incompletely understood. Herein, we sought to determine the effect of hypoxia and hyperoxia on venous capacity and compliance in the lower limb. In sixteen healthy individuals (7 women; age: 28.3±7.6 years, mean±SD), we assessed peripheral oxygen saturation (SpO<sub>2</sub>), the cross-sectional area (CSA) of the great saphenous vein (GSV; Doppler ultrasound) and calf volume (strain gauge plethysmography) during a standard 60 mmHg thigh cuff inflation-deflation protocol. Separate trials were undertaken during breathing of room air, hypoxia (fraction in inspired oxygen [FIO<sub>2</sub>]: 0.10) and hyperoxia (FIO<sub>2</sub>: 0.50), according to a single-blinded, randomized design. Lower limb pressure-CSA and pressure-volume relationships were modelled using a quadratic regression equation and compliance derived. SpO<sub>2</sub> was decreased by hypoxia (83.6±5.6%) and increased by hyperoxia (98.7±0.5%) compared to room air (96.4±1.0%, p<0.001). Compared to room air (17.0±7.9 mm<sup>2</sup>), hypoxia decreased GSV CSA (13.4±5.7 mm<sup>2</sup>, p<0.001), while no change was observed with hyperoxia (17.1±8.7 mm<sup>2</sup>, p=0.883). GSV compliance derived from the pressure-CSA relationships were elevated approximately two-fold with hyperoxia (-0.0061±0.0046 a.u.) when compared to room air (-0.0029±0.002 a.u., p=0.027) and hypoxia (-0.0030±0.0032 a.u., p=0.007). No differences were observed in calf pressure-volume parameters with either hypoxia or hyperoxia (p > 0.05). Our data indicate that GSV capacity is reduced by hypoxia, and that GSV compliance is increased by hyperoxia, thus highlighting the often overlooked role of oxygen in the regulation of venous circulation.
dc.format.medium Print-Electronic
dc.language eng
dc.publisher American Physiological Society
dc.relation.ispartofseries American journal of physiology. Regulatory, integrative and comparative physiology
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.subject Hyperoxia
dc.subject Hypoxia
dc.subject Venous capacity
dc.subject Venous compliance
dc.subject 06 Biological Sciences
dc.subject 11 Medical and Health Sciences
dc.title Effects of hypoxia and hyperoxia on venous capacity and compliance in healthy men and women.
dc.type Journal Article
dc.identifier.doi 10.1152/ajpregu.00319.2021
dc.date.updated 2022-04-04T21:23:55Z
dc.rights.holder Copyright: The author en
dc.identifier.pmid 35319299 (pubmed)
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/35319299
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/RetrictedAccess en
pubs.subtype Journal Article
pubs.elements-id 891845
pubs.org-id Medical and Health Sciences
pubs.org-id Medical Sciences
pubs.org-id Physiology Division
dc.identifier.eissn 1522-1490
pubs.record-created-at-source-date 2022-04-05
pubs.online-publication-date 2022-03-23


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