Longitudinal Associations of Mental Disorders With Dementia: 30-Year Analysis of 1.7 Million New Zealand Citizens.

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dc.contributor.author Richmond-Rakerd, Leah S
dc.contributor.author D'Souza, Stephanie
dc.contributor.author Milne, Barry J
dc.contributor.author Caspi, Avshalom
dc.contributor.author Moffitt, Terrie E
dc.coverage.spatial United States
dc.date.accessioned 2022-06-10T04:45:27Z
dc.date.available 2022-06-10T04:45:27Z
dc.date.issued 2022-04
dc.identifier.citation (2022). JAMA Psychiatry, 79(4), 333-340.
dc.identifier.issn 2168-622X
dc.identifier.uri https://hdl.handle.net/2292/59726
dc.description.abstract <h4>Importance</h4>Mental disorders are an underappreciated category of modifiable risk factors for dementia. Developing an evidence base about the link between mental disorders and dementia risk requires studies that use large, representative samples, consider the full range of psychiatric conditions, ascertain mental disorders from early life, use long follow-ups, and distinguish between Alzheimer disease and related dementias.<h4>Objective</h4>To test whether mental disorders antedate dementia across 3 decades of observation.<h4>Design, setting, and participants</h4>This population-based administrative register study of mental disorders and Alzheimer disease and related dementias included all individuals born in New Zealand between 1928 and 1967 who resided in the country for any time during the 30-year observation period between July 1988 and June 2018. Data were from the New Zealand Integrated Data Infrastructure, a collection of whole-of-population administrative data sources linked at the individual level. Data were analyzed from October 2020 to November 2021.<h4>Exposures</h4>Diagnoses of mental disorders were ascertained from public-hospital records.<h4>Main outcomes and measures</h4>Diagnoses of dementia were ascertained from public-hospital records, mortality records, and pharmaceutical records.<h4>Results</h4>Of 1 711 386 included individuals, 866 301 (50.6%) were male, and individuals were aged 21 to 60 years at baseline. Relative to individuals without a mental disorder, those with a mental disorder were at increased risk of developing subsequent dementia (relative risk [RR], 4.24; 95% CI, 4.07-4.42; hazard ratio, 6.49; 95% CI, 6.25-6.73). Among individuals with dementia, those with a mental disorder developed dementia a mean of 5.60 years (95% CI, 5.31-5.90) earlier than those without a mental disorder. Associations held across sex and age and after accounting for preexisting chronic physical diseases and socioeconomic deprivation. Associations were present across different types of mental disorders and self-harm behavior (RRs ranged from 2.93 [95% CI, 2.66-3.21] for neurotic disorders to 6.20 [95% CI, 5.67-6.78] for psychotic disorders), and were evident for Alzheimer disease (RR, 2.76; 95% CI, 2.45-3.11) and all other dementias (RR, 5.85; 95% CI, 5.58-6.13).<h4>Conclusions and relevance</h4>In this study, mental disorders were associated with the onset of dementia in the population. Ameliorating mental disorders in early life might also ameliorate neurodegenerative conditions and extend quality of life in old age.
dc.format.medium Print
dc.language eng
dc.publisher American Medical Association (AMA)
dc.relation.ispartofseries JAMA psychiatry
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Humans
dc.subject Alzheimer Disease
dc.subject Chronic Disease
dc.subject Mental Disorders
dc.subject Psychotic Disorders
dc.subject Quality of Life
dc.subject Adult
dc.subject Middle Aged
dc.subject New Zealand
dc.subject Male
dc.subject Young Adult
dc.subject Acquired Cognitive Impairment
dc.subject Aging
dc.subject Neurodegenerative
dc.subject Dementia
dc.subject Behavioral and Social Science
dc.subject Neurosciences
dc.subject Brain Disorders
dc.subject Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)
dc.subject Serious Mental Illness
dc.subject Clinical Research
dc.subject Alzheimer's Disease
dc.subject Prevention
dc.subject Mental Health
dc.subject Neurological
dc.subject Science & Technology
dc.subject Life Sciences & Biomedicine
dc.subject Psychiatry
dc.subject LATE-LIFE
dc.subject DEPRESSION
dc.subject MIDLIFE
dc.subject 1199 Other Medical and Health Sciences
dc.subject 1701 Psychology
dc.subject 1702 Cognitive Sciences
dc.title Longitudinal Associations of Mental Disorders With Dementia: 30-Year Analysis of 1.7 Million New Zealand Citizens.
dc.type Journal Article
dc.identifier.doi 10.1001/jamapsychiatry.2021.4377
pubs.issue 4
pubs.begin-page 333
pubs.volume 79
dc.date.updated 2022-05-30T22:10:33Z
dc.rights.holder Copyright: The author en
dc.identifier.pmid 35171209 (pubmed)
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/35171209
pubs.end-page 340
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype research-article
pubs.subtype Journal Article
pubs.elements-id 883356
pubs.org-id Arts
pubs.org-id Arts Research
pubs.org-id Compass
dc.identifier.eissn 2168-6238
dc.identifier.pii 2789298
pubs.record-created-at-source-date 2022-05-31

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