Synthesis of methyl 2- and 4-pyridyl disulfide from 2- and 4-thiopyridone and methyl methanethiosulfonate.

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dc.contributor.author Kitson, TM
dc.contributor.author Loomes, KM
dc.coverage.spatial United States
dc.date.accessioned 2022-06-13T03:06:49Z
dc.date.available 2022-06-13T03:06:49Z
dc.date.issued 1985-05
dc.identifier.citation (1985). Analytical Biochemistry, 146(2), 429-430.
dc.identifier.issn 0003-2697
dc.identifier.uri https://hdl.handle.net/2292/59778
dc.description.abstract In 1982, methyl 2-pyridyl disulfide was reported as a new reagent for the titration of thiol groups in peptides and proteins and for their temporary blocking with the thiomethyl group [T. Kimura et al. (1982) Anal. Biochem. 122, 274-282]. We have synthesized this compound (and its 4-pyridyl isomer) by a rapid and convenient procedure which is preferable to that in the original report. Our method involves the thiomethylation of the appropriate thiopyridone by methyl methanethiosulfonate.
dc.format.medium Print
dc.language eng
dc.publisher Elsevier BV
dc.relation.ispartofseries Analytical biochemistry
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
dc.subject Methyl Methanesulfonate
dc.subject Sulfhydryl Compounds
dc.subject Pyridines
dc.subject Sulfhydryl Reagents
dc.subject Chemistry
dc.subject Chemical Phenomena
dc.subject 0601 Biochemistry and Cell Biology
dc.subject 0301 Analytical Chemistry
dc.subject 0399 Other Chemical Sciences
dc.title Synthesis of methyl 2- and 4-pyridyl disulfide from 2- and 4-thiopyridone and methyl methanethiosulfonate.
dc.type Journal Article
dc.identifier.doi 10.1016/0003-2697(85)90563-9
pubs.issue 2
pubs.begin-page 429
pubs.volume 146
dc.date.updated 2022-05-03T05:12:45Z
dc.rights.holder Copyright: The author en
dc.identifier.pmid 4025805 (pubmed)
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/4025805
pubs.end-page 430
pubs.publication-status Published
dc.rights.accessrights http://purl.org/eprint/accessRights/RetrictedAccess en
pubs.subtype Journal Article
pubs.elements-id 126966
pubs.org-id Science
pubs.org-id Biological Sciences
pubs.org-id Science Research
pubs.org-id Maurice Wilkins Centre (2010-2014)
dc.identifier.eissn 1096-0309
dc.identifier.pii 0003-2697(85)90563-9
pubs.record-created-at-source-date 2022-05-03


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