The first mitochondrial genomes of endosymbiotic rhabdocoels illustrate evolutionary relaxation of atp8 and genome plasticity in flatworms.

Show simple item record Monnens, Marlies Thijs, Sofie Briscoe, Andrew G Clark, Miriam Frost, Emily Joy Littlewood, D Tim J Sewell, Mary Smeets, Karen Artois, Tom Vanhove, Maarten PM
dc.coverage.spatial Netherlands 2022-06-13T22:42:26Z 2022-06-13T22:42:26Z 2020-11
dc.identifier.citation (2020). International Journal of Biological Macromolecules, 162, 454-469.
dc.identifier.issn 0141-8130
dc.description.abstract The first three mitochondrial (mt) genomes of endosymbiotic turbellarian flatworms are characterised for the rhabdocoels Graffilla buccinicola, Syndesmis echinorum and S. kurakaikina. Interspecific comparison of the three newly obtained sequences and the only previously characterised rhabdocoel, the free-living species Bothromesostoma personatum, reveals high mt genomic variability, including numerous rearrangements. The first intrageneric comparison within rhabdocoels shows that gene order is not fully conserved even between congeneric species. Atp8, until recently assumed absent in flatworms, was putatively annotated in two sequences. Selection pressure was tested in a phylogenetic framework and is shown to be significantly relaxed in this and another protein-coding gene: cox1. If present, atp8 appears highly derived in platyhelminths and its functionality needs to be addressed in future research. Our findings for the first time allude to a large degree of undiscovered (mt) genomic plasticity in rhabdocoels. It merits further attention whether this variation is correlated with a symbiotic lifestyle. Our results illustrate that this phenomenon is widespread in flatworms as a whole and not exclusive to the better-studied neodermatans.
dc.format.medium Print-Electronic
dc.language eng
dc.publisher Elsevier BV
dc.relation.ispartofseries International journal of biological macromolecules
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
dc.subject Animals
dc.subject Platyhelminths
dc.subject Mitochondrial Proton-Translocating ATPases
dc.subject Helminth Proteins
dc.subject Evolution, Molecular
dc.subject Genome, Helminth
dc.subject Genome, Mitochondrial
dc.subject Endosymbiosis
dc.subject Genomics
dc.subject Mitochondrion
dc.subject Platyhelminthes
dc.subject Rhabdocoela
dc.subject Biotechnology
dc.subject Human Genome
dc.subject Genetics
dc.subject 0604 Genetics
dc.subject 0601 Biochemistry and Cell Biology
dc.title The first mitochondrial genomes of endosymbiotic rhabdocoels illustrate evolutionary relaxation of atp8 and genome plasticity in flatworms.
dc.type Journal Article
dc.identifier.doi 10.1016/j.ijbiomac.2020.06.025
pubs.begin-page 454
pubs.volume 162 2022-05-16T05:13:02Z
dc.rights.holder Copyright: The author en
dc.identifier.pmid 32512097 (pubmed)
pubs.end-page 469
pubs.publication-status Published
dc.rights.accessrights en
pubs.subtype Journal Article
pubs.elements-id 805670 Science Biological Sciences
dc.identifier.eissn 1879-0003
dc.identifier.pii S0141-8130(20)33465-6
pubs.record-created-at-source-date 2022-05-16

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